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Cluster information : Pactamycin


close this sectionCompound

Entry namePactamycin
PKS TypeTypeI iterative
Starter Unitacetyl-CoA
Chain Length4
Sugar Unitnone
ClassificationAminocyclitol
ActivityAntibacterial
Antiprotozoal
Antitumor
Antiviral
Toxic
CompositionC28H38N4O8
Pactamycin

close this sectionOriginal source

Organism
StrainATCC 27456 (=NBRC 13433)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Pact_00200
pctS
1 acetyl-CoA
malonyl-CoA
KS62..436
AT642..957
TH965..1129
KR1502..1695
ACP1779..1856

close this sectionReference

Cloning of the pactamycin biosynthetic gene cluster and characterization of a crucial glycosyltransferase prior to a unique cyclopentane ring formation.
Kudo F, Kasama Y, Hirayama T, Eguchi T
[PMID: 17827660]J Antibiot (Tokyo). 60 (2007) 492-503
Deciphering pactamycin biosynthesis and engineered production of new pactamycin analogues.
Ito T, Roongsawang N, Shirasaka N, Lu W, Flatt PM, Kasanah N, Miranda C, Mahmud T
[PMID: 19670201]Chembiochem. 10 (2009) 2253-65
Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites.
Lu W, Roongsawang N, Mahmud T
[PMID: 21513878]Chem Biol. 18 (2011) 425-31
A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.
Hirayama A, Eguchi T, Kudo F
[PMID: 23744829]Chembiochem. 14 (2013) 1198-203
Mechanism-Based Trapping of the Quinonoid Intermediate by Using the K276R Mutant of PLP-Dependent 3-Aminobenzoate Synthase PctV in the Biosynthesis of Pactamycin.
Hirayama A, Miyanaga A, Kudo F, Eguchi T
[PMID: 26426567]Chembiochem. 16 (2015) 2484-90

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Pactamycin
Genomic nucleotide sequence
43 KB
Nucleotide sequences of the coding regions
38 KB
Translation of the coding sequences
14 KB
List of genes/ORFs
4 KB

 

 
GenBank format
86 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2015-02-12[Update]
  • 2013-01-16[Release]