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Cluster information : FD-891


close this sectionCompound

Entry nameFD-891
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length13
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAntitumor
Toxic
CompositionC33H54O8
FD-891

close this sectionOriginal source

Organism
StrainA-8890
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

FD891_00010
gfsA
0 malonyl-CoA
1 methylmalonyl-CoA
2 methylmalonyl-CoA
3 malonyl-CoA
4 malonyl-CoA
FD891_00020
gfsB
5 methylmalonyl-CoA
6 malonyl-CoA
7 malonyl-CoA
FD891_00030
gfsC
8 malonyl-CoA
FD891_00040
gfsD
9 malonyl-CoA
10 methylmalonyl-CoA
FD891_00050
gfsE
11 methylmalonyl-CoA
12 methylmalonyl-CoA
KSQ26..398
AT564..876
ACP946..1016
KS1037..1404
AT1562..1886
KR2159..2338
ACP2443..2513
KS2538..2914
AT3069..3385
KR3711..3888
ACP3989..4059
KS4084..4464
AT4629..4926
KR5280..5459
ACP5562..5632
KS5654..6031
AT6189..6511
DH6560..6725
KR7037..7217
ACP7322..7396
KS58..434
AT611..928
DH976..1148
ER1478..1777
KR1787..1967
ACP2075..2145
KS2168..2544
AT2710..3033
KR3373..3552
ACP3655..3725
KS3746..4123
AT4279..4601
DH4649..4813
KR5132..5307
ACP5412..5482
KS34..409
AT564..886
DH935..1103
ER1152..1457
KR1786..1966
ACP2074..2144
KS34..410
AT572..894
DH943..1106
KR1383..1558
ACP1660..1730
KS1753..2128
AT2289..2643
dh2691..2849
KR3185..3365
ACP3469..3539
KS34..410
AT582..896
DH944..1107
KR1380..1555
ACP1657..1727
KS1750..2125
AT2284..2604
DH2656..2820
KR3140..3315
ACP3421..3491
TE3584..3794

close this sectionReference

Cloning and characterization of the biosynthetic gene cluster of 16-membered macrolide antibiotic FD-891: involvement of a dual functional cytochrome P450 monooxygenase catalyzing epoxidation and hydroxylation.
Kudo F, Motegi A, Mizoue K, Eguchi T
[PMID: 20589823]Chembiochem. 11 (2010) 1574-82
Parallel Post-Polyketide Synthase Modification Mechanism Involved in FD-891 Biosynthesis in Streptomyces graminofaciens A-8890.
Kudo F, Kawamura K, Furuya T, Yamanishi H, Motegi A, Komatsubara A, Numakura M, Miyanaga A, Eguchi T
[PMID: 26630077]Chembiochem. 17 (2016) 233-8

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
FD-891
Genomic nucleotide sequence
75 KB
Nucleotide sequences of the coding regions
72 KB
Translation of the coding sequences
24 KB
List of genes/ORFs
1 KB

 

 
GenBank format
135 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2014-06-25[Update]
  • 2014-03-10[Release]