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Cluster information : Avilamycin


close this sectionCompound

Entry nameAvilamycin
PKS TypeTypeI iterative
Starter Unitacetyl-CoA
Chain Length4
Sugar Unit2,6-di-O-methyl-D-mannose
2-O-isobutyryl-L-lyxose
2-deoxy-D-evalose
4-O-methyl-D-fucose
D-olivoses
eurekanate
ClassificationOrthosomycin
ActivityAntibacterial
CompositionA: C61H88Cl2O32
Avilamycin

close this sectionOriginal source

Organism
StrainTü57
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Avil_00210
aviM
1 acetyl-CoA
malonyl-CoA
KS24..406
AT559..873
TH882..1027
ACP1210..1279

close this sectionReference

Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tu57.
Gaisser S, Trefzer A, Stockert S, Kirschning A, Bechthold A
[PMID: 9335272]J Bacteriol. 179 (1997) 6271-8
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A
[PMID: 11181344]Antimicrob Agents Chemother. 45 (2001) 690-5
Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.
Weitnauer G, Muhlenweg A, Trefzer A, Hoffmeister D, Sussmuth RD, Jung G, Welzel K, Vente A, Girreser U, Bechthold A
[PMID: 11410376]Chem Biol. 8 (2001) 569-81
Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tu57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1.
Weitnauer G, Gaisser S, Kellenberger L, Leadlay PF, Bechthold A
[PMID: 11832501]Microbiology. 148 (2002) 373-9
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.
Mosbacher TG, Bechthold A, Schulz GE
[PMID: 12742024]J Mol Biol. 329 (2003) 147-57
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.
Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S
[PMID: 12828631]Mol Microbiol. 49 (2003) 309-18
Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.
Weitnauer G, Hauser G, Hofmann C, Linder U, Boll R, Pelz K, Glaser SJ, Bechthold A
[PMID: 15489167]Chem Biol. 11 (2004) 1403-11
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
Mosbacher TG, Bechthold A, Schulz GE
[PMID: 15581897]J Mol Biol. 345 (2005) 535-45
Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A.
Treede I, Hauser G, Muhlenweg A, Hofmann C, Schmidt M, Weitnauer G, Glaser S, Bechthold A
[PMID: 15640214]Appl Environ Microbiol. 71 (2005) 400-6
Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis.
Hofmann C, Boll R, Heitmann B, Hauser G, Durr C, Frerich A, Weitnauer G, Glaser SJ, Bechthold A
[PMID: 16242656]Chem Biol. 12 (2005) 1137-43
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme.
Boll R, Hofmann C, Heitmann B, Hauser G, Glaser S, Koslowski T, Friedrich T, Bechthold A
[PMID: 16537546]J Biol Chem. 281 (2006) 14756-63
Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4.
Martinez-Fleites C, Proctor M, Roberts S, Bolam DN, Gilbert HJ, Davies GJ
[PMID: 17113996]Chem Biol. 13 (2006) 1143-52
Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators.
Rebets Y, Boll R, Horbal L, Fedorenko V, Bechthold A
[PMID: 19609289]J Antibiot (Tokyo). 62 (2009) 461-4
Draft Genome Sequence of Streptomyces viridochromogenes Strain Tu57, Producer of Avilamycin.
Gruning BA, Erxleben A, Hahnlein A, Gunther S
[PMID: 23788550]Genome Announc. 1 (2013)

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Avilamycin
Genomic nucleotide sequence
60 KB
Nucleotide sequences of the coding regions
55 KB
Translation of the coding sequences
20 KB
List of genes/ORFs
8 KB

 

 
GenBank format
125 KB

close this sectionHistory

  • 2015-02-12[Update]
  • 2013-12-27[Release]