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Cluster information : Tautomycetin

Compound

Entry name	Tautomycetin
PKS Type	TypeI modular
Classification	Tetronic Acid Derivative
Starter Unit	malonyl-CoA
Chain Length	10
Sugar Unit	none
Activity	Antifungal Antitumor Immunosuppressive
Composition	C₃₃H₅₀O₁₀

Original source

Organism	Streptomyces sp.
Strain	CK4412
Contig	DQ983361

PKS/NRPS Module

Tatmc_00080 tmcA	0	malonyl-CoA
	1	methylmalonyl-CoA
	2	malonyl-CoA
	3	methylmalonyl-CoA
	4	malonyl-CoA
	5	methylmalonyl-CoA
Tatmc_00090 tmcB	6	methylmalonyl-CoA
	7	malonyl-CoA
	8	ethylmalonyl-CoA not conserved XAGHS
	9	malonyl-CoA

KSQ	125..492

AT	646..917

ACP	992..1066

KS	1083..1450

AT	1621..1926

dh	1973..2120

KR	2391..2567

ACP	2668..2738

KS	2757..3133

AT	3296..3563

KR	3882..4062

ACP	4164..4234

KS	4257..4634

AT	4787..5091

dh	5136..5299

kr	5556..5712

ACP	5793..5863

KS	5890..6264

AT	6415..6682

dh	6761..6928

KR	7215..7391

ACP	7486..7560

KS	7583..7958

AT	8111..8415

DH	8463..8626

ER	8926..9232

KR	9246..9425

ACP	9527..9597

KS	78..453

AT	625..929

DH	977..1143

ER	1424..1726

KR	1736..1916

ACP	2016..2086

KS	2109..2483

AT	2632..2900

DH	2978..3142

ER	3447..3750

KR	3760..3935

ACP	4028..4098

KS	4120..4496

AT	4646..4960

DH	5008..5166

KR	5460..5636

ACP	5733..5807

KS	5830..6205

AT	6358..6625

Reference

Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.: Choi SS, Hur YA, Sherman DH, Kim ES
[PMID: 17379718]Microbiology. 153 (2007) 1095-102
Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.: Hur YA, Choi SS, Sherman DH, Kim ES
[PMID: 18832298]Microbiology. 154 (2008) 2912-9
Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412.: Park SH, Choi SS, Kim YJ, Chang YK, Sherman DH, Kim ES
[PMID: 19408025]J Ind Microbiol Biotechnol. 36 (2009) 993-8
Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.: Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH
[PMID: 20623733]Angew Chem Int Ed Engl. 49 (2010) 5726-30