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Cluster information : Tautomycetin


close this sectionCompound

Entry nameTautomycetin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length10
Sugar Unitnone
ClassificationTetronic Acid Derivative
ActivityAntifungal
Antitumor
Immunosuppressive
CompositionC33H50O10
Tautomycetin

close this sectionOriginal source

Organism
StrainCK4412
Contig
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close this sectionPKS/NRPS Module

Tatmc_00080
tmcA
0 malonyl-CoA
1 methylmalonyl-CoA
2 malonyl-CoA
3 methylmalonyl-CoA
4 malonyl-CoA
5 methylmalonyl-CoA
Tatmc_00090
tmcB
6 methylmalonyl-CoA
7 malonyl-CoA
8 ethylmalonyl-CoA
not conserved XAGHS
9 malonyl-CoA
KSQ125..492
AT646..917
ACP992..1066
KS1083..1450
AT1621..1926
dh1973..2120
KR2391..2567
ACP2668..2738
KS2757..3133
AT3296..3563
KR3882..4062
ACP4164..4234
KS4257..4634
AT4787..5091
dh5136..5299
kr5556..5712
ACP5793..5863
KS5890..6264
AT6415..6682
dh6761..6928
KR7215..7391
ACP7486..7560
KS7583..7958
AT8111..8415
DH8463..8626
ER8926..9232
KR9246..9425
ACP9527..9597
KS78..453
AT625..929
DH977..1143
ER1424..1726
KR1736..1916
ACP2016..2086
KS2109..2483
AT2632..2900
DH2978..3142
ER3447..3750
KR3760..3935
ACP4028..4098
KS4120..4496
AT4646..4960
DH5008..5166
KR5460..5636
ACP5733..5807
KS5830..6205
AT6358..6625
KR6960..7140
ACP7242..7312
TE7387..7600

close this sectionReference

Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.
Choi SS, Hur YA, Sherman DH, Kim ES
[PMID: 17379718]Microbiology. 153 (2007) 1095-102
Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.
Hur YA, Choi SS, Sherman DH, Kim ES
[PMID: 18832298]Microbiology. 154 (2008) 2912-9
Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412.
Park SH, Choi SS, Kim YJ, Chang YK, Sherman DH, Kim ES
[PMID: 19408025]J Ind Microbiol Biotechnol. 36 (2009) 993-8
Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.
Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH
[PMID: 20623733]Angew Chem Int Ed Engl. 49 (2010) 5726-30
Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.
Tripathi A, Choi SS, Sherman DH, Kim ES
[PMID: 27277081]J Ind Microbiol Biotechnol. 43 (2016) 1189-93

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Tautomycetin
Genomic nucleotide sequence
71 KB
Nucleotide sequences of the coding regions
69 KB
Translation of the coding sequences
24 KB
List of genes/ORFs
2 KB

 

 
GenBank format
127 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2012-06-04[Release]