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Cluster information : Hedamycin


close this sectionCompound

Entry nameHedamycin
PKS TypeTypeI modular
TypeII
Starter Unit2,4-hexadienyl-ACP
Chain Length12
Sugar Unitalpha-L-N,N-dimethylvancosamine
beta-D-angolosamine
ClassificationPluramycin
ActivityAntitumor
CompositionC41H50N2O11
Hedamycin

close this sectionOriginal source

Organism
StrainATCC 15422
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Heda_00020
hedT
0 malonyl-CoA
Heda_00010
hedU
1 malonyl-CoA
2
KSQ20..380
AT542..858
ACP930..969
KS48..422
AT574..886
DH931..1091
KR1380..1560
ACP1664..1734
KS1766..2124
KS7..376
CLF4..361
ACP239..312

close this sectionReference

The hedamycin locus implicates a novel aromatic PKS priming mechanism.
Bililign T, Hyun CG, Williams JS, Czisny AM, Thorson JS
[PMID: 15271354]Chem Biol. 11 (2004) 959-69
In vivo and in vitro analysis of the hedamycin polyketide synthase.
Das A, Khosla C
[PMID: 19942143]Chem Biol. 16 (2009) 1197-207
Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities.
Javidpour P, Das A, Khosla C, Tsai SC
[PMID: 21776967]Biochemistry. 50 (2011) 7426-39

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Hedamycin
Genomic nucleotide sequence
46 KB
Nucleotide sequences of the coding regions
43 KB
Translation of the coding sequences
16 KB
List of genes/ORFs
5 KB

 

 
GenBank format
94 KB

close this sectionHistory

  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-08-03[Release]