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Cluster information : Geldanamycin


close this sectionCompound

Entry nameGeldanamycin
PKS TypeTypeI modular
Starter Unit3-amino-5-hydroxybenzoic acid (AHBA)
Chain Length8
Sugar Unitnone
ClassificationAnsamycin
ActivityAntitumor
Antivirus
CompositionC29H40N2O9
Geldanamycin

close this sectionOriginal source

Organism
Strain17997
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Gelda_00010
gdmPKS
6
7 methylmalonyl-CoA
AT1..94
DH142..302
ER605..905
KR915..1095
ACP1197..1267
KS1294..1669
AT1836..2152
DH2200..2362
KR2670..2850
ACP2956..3026

close this sectionReference

Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.
He W, Wu L, Gao Q, Du Y, Wang Y
[PMID: 16502293]Curr Microbiol. 52 (2006) 197-203
The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.
He W, Lei J, Liu Y, Wang Y
[PMID: 18214443]Arch Microbiol. 189 (2008) 501-10
A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997.
Li Y, He W, Wang Y, Wang Y, Shao R
[PMID: 18667782]J Antibiot (Tokyo). 61 (2008) 347-55
7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997.
Ni S, Wu L, Wang H, Wang Y, He W, Li Y, Jia C, Li S, Wang Y
[PMID: 20683449]J Antibiot (Tokyo). 63 (2010) 623-5
The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B
[PMID: 21682254]Org Lett. 13 (2011) 3726-9
Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.
Lin L, Ni S, Wu L, Wang Y, Wang Y, Tao P, He W, Wang X
[PMID: 21979086]Biosci Biotechnol Biochem. 75 (2011) 2042-5
Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.
Li T, Ni S, Jia C, Wang H, Sun G, Wu L, Gan M, Shan G, He W, Lin L, Zhou H, Wang Y
[PMID: 22849774]J Nat Prod. 75 (2012) 1480-4
19-[(1'S,4'R)-4'-Hydroxy-1'-methoxy-2'-oxopentyl]geldanamycin, a natural geldanamycin analogue from Streptomyces hygroscopicus 17997.
Li S, Ni S, Wu L, Li L, Jiang B, Wang H, Sun G, Gan M, Li J, He W, Lin L, Wang Y, Bai S, Si S
[PMID: 23656556]J Nat Prod. 76 (2013) 969-73
Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis.
Ni S, Jiang B, Wu L, Wang Y, Zhou H, He W, Wang H, Zhu J, Li S, Li T, Zhang K
[PMID: 24105607]J Antibiot (Tokyo). 67 (2014) 183-5

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Geldanamycin
Genomic nucleotide sequence
38 KB
Nucleotide sequences of the coding regions
11 KB
Translation of the coding sequences
7 KB
List of genes/ORFs
1 KB

 

 
GenBank format
76 KB
AF521894
Genomic nucleotide sequence
9 KB
Nucleotide sequences of the coding regions
8 KB
Translation of the coding sequences
3 KB
List of genes/ORFs
2 KB

 

 

 
DQ914285
Genomic nucleotide sequence
29 KB
Nucleotide sequences of the coding regions
27 KB
Translation of the coding sequences
9 KB
List of genes/ORFs
2 KB

 

 

 

close this sectionHistory

  • 2014-06-25[Update]
  • 2013-12-27[Release]