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Cluster information : Rimocidin


close this sectionCompound

Entry nameRimocidin
PKS TypeTypeI modular
Starter UnitRimocidin: butyryl-CoA
CE-108: acetyl-CoA
Chain Length14
Sugar Unitmycosamine
ClassificationPolyene Macrolide
ActivityAntifungal
CompositionC39H61NO14
Rimocidin

close this sectionOriginal source

Organism
Strain108
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Rimoc_00080
rimA
0 acetyl-CoA for CE-108
butyryl-CoA for Rimocidin
Rimoc_00010
rimB
?
CoL51..457
ACP557..634
KS661..1037
AT1193..1517
ACP1592..1662
KR191..367
ACP470..540

close this sectionReference

Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108, in Streptomyces diastaticus var. 108.
Seco EM, Perez-Zuniga FJ, Rolon MS, Malpartida F
[PMID: 15123265]Chem Biol. 11 (2004) 357-66
A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.
Seco EM, Fotso S, Laatsch H, Malpartida F
[PMID: 16242652]Chem Biol. 12 (2005) 1093-101
The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis.
Seco EM, Miranzo D, Nieto C, Malpartida F
[PMID: 19707755]Appl Microbiol Biotechnol. 85 (2010) 1797-807
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.
Heia S, Borgos SE, Sletta H, Escudero L, Seco EM, Malpartida F, Ellingsen TE, Zotchev SB
[PMID: 21821762]Appl Environ Microbiol. 77 (2011) 6982-90
New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA.
Escudero L, Al-Refai M, Nieto C, Laatsch H, Malpartida F, Seco EM
[PMID: 26284936]PLoS One. 10 (2015) e0135891

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Rimocidin
Genomic nucleotide sequence
19 KB
Nucleotide sequences of the coding regions
18 KB
Translation of the coding sequences
6 KB
List of genes/ORFs
1 KB

 

 
GenBank format
39 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-03-28[Release]