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Cluster information : Geldanamycin


close this sectionCompound

Entry nameGeldanamycin
PKS TypeTypeI modular
Starter Unit3-amino-5-hydroxybenzoic acid (AHBA)
Chain Length8
Sugar Unitnone
ClassificationAnsamycin
ActivityAntitumor
Antivirus
CompositionC29H40N2O9
Geldanamycin2

close this sectionOriginal source

Organism
StrainNRRL 3602 (=NBRC 14620)
Contig
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close this sectionPKS/NRPS Module

Gelda2_00080
gdmAI
0
1 methylmalonyl-CoA
2 methoxymalonyl-ACP
3 methylmalonyl-CoA
Gelda2_00090
gdmAII
4 methylmalonyl-CoA
5 methoxymalonyl-ACP
Gelda2_00100
gdmAIII
6 malonyl-CoA
7 methylmalonyl-CoA
A36..442
PCP1012..1082
KS1102..1478
AT1642..1960
DH2009..2175
ER2486..2786
KR2796..2976
ACP3073..3147
KS3169..3543
AT3713..4034
DH4082..4242
ER4552..4850
KR4860..5040
ACP5143..5213
KS5242..5617
AT5780..6099
KR6405..6585
ACP6684..6757
KS34..409
AT573..890
DH939..1101
KR1432..1612
ACP1718..1788
KS1811..2186
AT2349..2670
KR2973..3151
ACP3255..3325
KS35..410
AT584..907
DH954..1118
ER1430..1730
KR1740..1920
ACP2022..2092
KS2119..2494
AT2662..2981
DH3029..3197
KR3510..3690
ACP3797..3867

close this sectionReference

Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.
Rascher A, Hu Z, Viswanathan N, Schirmer A, Reid R, Nierman WC, Lewis M, Hutchinson CR
[PMID: 12586396]FEMS Microbiol Lett. 218 (2003) 223-30
Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.
Rascher A, Hu Z, Buchanan GO, Reid R, Hutchinson CR
[PMID: 16085885]Appl Environ Microbiol. 71 (2005) 4862-71
Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum.
Kubota T, Brunjes M, Frenzel T, Xu J, Kirschning A, Floss HG
[PMID: 16927319]Chembiochem. 7 (2006) 1221-5
Production of ansamycin polyketide precursors in Escherichia coli.
Rude MA, Khosla C
[PMID: 17080682]J Antibiot (Tokyo). 59 (2006) 464-70
The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B
[PMID: 21682254]Org Lett. 13 (2011) 3726-9

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Geldanamycin
Genomic nucleotide sequence
81 KB
Nucleotide sequences of the coding regions
23 KB
Translation of the coding sequences
14 KB
List of genes/ORFs
2 KB

 

 
GenBank format
156 KB
AY952143
Genomic nucleotide sequence
11 KB
Nucleotide sequences of the coding regions
10 KB
Translation of the coding sequences
4 KB
List of genes/ORFs
2 KB

 

 

 
AY179507
Genomic nucleotide sequence
70 KB
Nucleotide sequences of the coding regions
68 KB
Translation of the coding sequences
23 KB
List of genes/ORFs
3 KB

 

 

 

close this sectionHistory

  • 2013-12-27[Release]