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Cluster information : Oviedomycin


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Entry nameOviedomycin
PKS TypeTypeII
Starter Unitacetyl-CoA
Chain Length10
Sugar Unitnone
ClassificationAngucycline
Benzanthraquinone
ActivityAntitumor
CompositionC19H10O7
Oviedomycin

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Organism
StrainATCC 11891
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS4..364
CLF6..365
ACP7..81

close this sectionReference

Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891.
Mendez C, Kunzel E, Lipata F, Lombo F, Cotham W, Walla M, Bearden DW, Brana AF, Salas JA, Rohr J
[PMID: 12027768]J Nat Prod. 65 (2002) 779-82
Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891.
Lombo F, Brana AF, Salas JA, Mendez C
[PMID: 15368568]Chembiochem. 5 (2004) 1181-7
Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.
Lombo F, Abdelfattah MS, Brana AF, Salas JA, Rohr J, Mendez C
[PMID: 18988223]Chembiochem. 10 (2009) 296-303
Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus.
Zabala D, Brana AF, Florez AB, Salas JA, Mendez C
[PMID: 24148183]Metab Eng. 20 (2013) 187-97

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Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Oviedomycin
Genomic nucleotide sequence
25 KB
Nucleotide sequences of the coding regions
24 KB
Translation of the coding sequences
9 KB
List of genes/ORFs
4 KB

 

 
GenBank format
55 KB

close this sectionHistory

  • 2014-06-25[Update]
  • 2013-01-16[Update]
  • 2012-08-03[Release]