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Cluster information : Salinomycin


close this sectionCompound

Entry nameSalinomycin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length15
Sugar Unitnone
ClassificationPolyether
ActivityAntibacterial
Antiprotozoal
Antitumor
Ionophore
CompositionC42H70O11
Salinomycin2

close this sectionOriginal source

Organism
StrainDSM 41398
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Salino_00910
salAI
0 malonyl-CoA
1 ethylmalonyl-CoA
2 malonyl-CoA
Salino_00920
salAII
3 methylmalonyl-CoA
4 malonyl-CoA
Salino_00930
salAIII
5 malonyl-CoA
6 malonyl-CoA
Salino_00940
salAIV
7 methylmalonyl-CoA
Salino_00950
salAV
8 methylmalonyl-CoA
9 ethylmalonyl-CoA
Salino_00960
salAVI
10 methylmalonyl-CoA
Salino_00970
salAVII
11 methylmalonyl-CoA
Salino_00980
salAVIII
12 methylmalonyl-CoA
13 malonyl-CoA
Salino_00990
salAIX
14 ethylmalonyl-CoA
15
KSQ23..388
AT545..864
ACP941..1011
KS1031..1407
AT1553..1875
DH1925..2088
KR2394..2574
ACP2681..2751
KS2776..3151
AT3311..3620
DH3667..3831
ER4163..4469
KR4479..4659
ACP4765..4835
KS34..409
AT570..887
DH937..1102
KR1398..1578
ACP1683..1753
KS1775..2151
AT2307..2617
DH2664..2828
ER3153..3459
KR3469..3649
ACP3756..3826
KS37..413
AT573..881
ACP1006..1076
KS1096..1472
AT1627..1936
KR2252..2433
ACP2539..2609
KS34..410
AT575..893
kr1196..1373
ACP1485..1555
KS34..409
AT587..905
DH955..1118
ER1453..1753
KR1763..1943
ACP2047..2117
KS2141..2517
AT2682..3005
KR3308..3487
ACP3596..3666
KS38..414
AT585..904
DH952..1115
ACP1281..1351
KS36..411
AT562..880
KR1202..1381
ACP1490..1565
KS34..409
AT571..889
KR1194..1373
ACP1479..1549
KS1572..1947
AT2103..2422
DH2470..2632
ER2968..3273
KR3283..3463
ACP3568..3638
KS38..411
AT565..887
KR1199..1378
ACP1484..1554
KS1580..1952

close this sectionReference

A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster.
Yurkovich ME, Tyrakis PA, Hong H, Sun Y, Samborskyy M, Kamiya K, Leadlay PF
[PMID: 22076845]Chembiochem. 13 (2012) 66-71
Site-specific modification of the anticancer and antituberculosis polyether salinomycin by biosynthetic engineering.
Luhavaya H, Williams SR, Hong H, Gonzaga de Oliveira L, Leadlay PF
[PMID: 25155178]Chembiochem. 15 (2014) 2081-5
Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
Luhavaya H, Dias MV, Williams SR, Hong H, de Oliveira LG, Leadlay PF
[PMID: 26377145]Angew Chem Int Ed Engl. 54 (2015) 13622-5
Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2).
Yin J, Hoffmann M, Bian X, Tu Q, Yan F, Xia L, Ding X, Stewart AF, Muller R, Fu J, Zhang Y
[PMID: 26459865]Sci Rep. 5 (2015) 15081

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Salinomycin
Genomic nucleotide sequence
201 KB
Nucleotide sequences of the coding regions
191 KB
Translation of the coding sequences
68 KB
List of genes/ORFs
12 KB

 

 
GenBank format
382 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2015-02-12[Update]
  • 2014-03-10[Release]