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Cluster information : Nanchangmycin


close this sectionCompound

Entry nameNanchangmycin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length15
Sugar Unit4-O-methyl-L-rhodinose
ClassificationPolyether
ActivityAntibacterial
Insecticidal
Ionophore
CompositionC47H78O14
Nanchangmycin

close this sectionOriginal source

Organism
StrainNS3226
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Nanch_00080
nanA1
0 malonyl-CoA
1 methylmalonyl-CoA
Nanch_00090
nanA2
2 methylmalonyl-CoA
Nanch_00100
nanA3
3 malonyl-CoA
4 methylmalonyl-CoA
Nanch_00110
nanA4
5 methylmalonyl-CoA
6 malonyl-CoA
Nanch_00120
nanA5
7 methylmalonyl-CoA
8 malonyl-CoA
Nanch_00130
nanA6
9 malonyl-CoA
Nanch_00200
nanA7
10 methylmalonyl-CoA
Nanch_00270
nanA8
11 methylmalonyl-CoA
12 methylmalonyl-CoA
Nanch_00250
nanA9
13
Nanch_00220
nanA10
13
Nanch_00260
nanA11
14 methylmalonyl-CoA
KSQ22..396
AT559..885
ACP955..1025
KS1047..1423
AT1586..1907
dh1966..2138
kr2491..2660
ACP2766..2836
KS34..410
AT576..895
DH945..1112
ER1445..1750
KR1760..1940
ACP2053..2123
KS42..415
AT576..921
DH969..1153
KR1494..1671
ACP1773..1843
KS1874..2251
AT2406..2727
DH2774..2939
ER3273..3580
KR3590..3770
ACP3873..3943
KS35..409
AT597..918
dh966..1134
kr1476..1653
ACP1728..1798
KS1822..2199
AT2360..2677
dh2724..2889
er3193..3503
KR3513..3693
ACP3798..3868
KS34..408
AT584..906
DH955..1125
KR1449..1629
ACP1727..1797
KS1820..2197
AT2354..2673
DH2723..2888
ER3226..3532
KR3542..3722
ACP3825..3895
KS35..411
AT564..883
kr1209..1386
ACP1510..1580
KS35..411
AT567..889
KR1213..1392
ACP1495..1565
KS48..424
AT580..896
KR1223..1402
ACP1502..1572
KS1598..1972
AT2133..2449
DH2511..2675
KR3014..3194
ACP3302..3372
KS43..418
AT589..688
ACP22..96
KS34..408
AT560..878
DH925..1086
ER1414..1719
KR1729..1909
ACP2005..2075

close this sectionReference

A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.
Sun Y, Zhou X, Dong H, Tu G, Wang M, Wang B, Deng Z
[PMID: 12770825]Chem Biol. 10 (2003) 431-41
Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.
Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane DE, Deng Z
[PMID: 16984884]Chem Biol. 13 (2006) 945-55
Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.
Liu T, Lin X, Zhou X, Deng Z, Cane DE
[PMID: 18482697]Chem Biol. 15 (2008) 449-58

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Nanchangmycin
Genomic nucleotide sequence
134 KB
Nucleotide sequences of the coding regions
108 KB
Translation of the coding sequences
37 KB
List of genes/ORFs
4 KB

 

 
GenBank format
239 KB

close this sectionHistory

  • 2013-05-28[Update]
  • 2012-10-02[Update]
  • 2012-08-03[Update]
  • 2012-04-26[Release]