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Cluster information : Maduropeptin


close this sectionCompound

Entry nameMaduropeptin
Moiety descriptionA: enediyne core
B: 3,6-dimethylsalicylic acid moiety
C: (S)-3-(2-chloro-3-hydroxy-4-methoxyphenyl)-3-hydroxypropionic acid moiety
PKS TypeA: TypeI iterative
B: TypeI iterative
C: NRPS
Starter UnitA: acetyl-CoA
B: acetyl-CoA
Chain LengthA: 8
B: 4
Sugar Unitmadurose
ClassificationEnediyne
ActivityAntibiotic
Antitumor
CompositionC39H39ClN2O11
Maduropeptin

close this sectionOriginal source

Organism
StrainATCC 39144
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

AMadu_00440
mdpE
1 acetyl-CoA
malonyl-CoA
BMadu_00170
mdpB
1 acetyl-CoA
malonyl-CoA
CMadu_00290
mdpC5
1
Madu_00320
mdpC1
1 L-alpha-tyrosine
Madu_00330
mdpC2
1
KS4..414
AT618..846
ACP934..1028
KR1217..1397
DH1467..1622
PPT1722..1937
KS5..379
AT547..862
TH870..1016
KR1379..1571
ACP1667..1731
C24..324
C14..284
A524..934
PCP1019..1086
PCP14..81

close this sectionReference

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.
Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM
[PMID: 12536216]Nat Biotechnol. 21 (2003) 187-90
Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.
Van Lanen SG, Oh TJ, Liu W, Wendt-Pienkowski E, Shen B
[PMID: 17918933]J Am Chem Soc. 129 (2007) 13082-94
Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate.
Ling J, Horsman GP, Huang SX, Luo Y, Lin S, Shen B
[PMID: 20718468]J Am Chem Soc. 132 (2010) 12534-6
Enediyne polyketide synthases stereoselectively reduce the beta-ketoacyl intermediates to beta-D-hydroxyacyl intermediates in enediyne core biosynthesis.
Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B
[PMID: 25019332]Org Lett. 16 (2014) 3958-61

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Maduropeptin
Genomic nucleotide sequence
86 KB
Nucleotide sequences of the coding regions
74 KB
Translation of the coding sequences
27 KB
List of genes/ORFs
8 KB

 

 
GenBank format
166 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2015-02-12[Update]
  • 2013-12-27[Release]