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Cluster information : Cryptophycin 1


close this sectionCompound

Entry nameCryptophycin 1
PKS TypePKS-NRPS hybrid
Starter Unittrans-cinnamic acid
Chain Length4
Sugar Unitnone
ClassificationPeptide-Polyketide Hybrid
ActivityToxic
CompositionC35H43ClN2O8
Cryptophycin 1

close this sectionOriginal source

Organism
StrainATCC 53789
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Crypto_00010
crpA
0
1 malonyl-CoA
Crypto_00020
crpB
2 malonyl-CoA
3 malonyl-CoA
Crypto_00030
crpC
4 L-tyrosine
Crypto_00040
crpD
5 alpha-methyl-beta-alanine
6 2-keto-isocaproic acid
A61..477
PCP587..654
KS680..1068
AT1232..1552
DH1595..1735
CM2115..2215
KR2538..2717
ACP2819..2889
KS45..420
AT579..900
KR1241..1420
ACP1524..1594
KS1619..1998
AT2154..2470
DH2518..2688
KR3082..3261
ACP3365..3434
C60..356
A555..947
OM990..1265
PCP1389..1459
E1472..1937
C12..314
A501..968
PCP1052..1119
C1139..1440
A1899..2315
KR2660..2846
PCP2981..3048
TE3069..3321

close this sectionReference

Cryptophycin anticancer drugs revisited.
Rohr J
[PMID: 17240971]ACS Chem Biol. 1 (2006) 747-50
Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts.
Magarvey NA, Beck ZQ, Golakoti T, Ding Y, Huber U, Hemscheidt TK, Abelson D, Moore RE, Sherman DH
[PMID: 17240975]ACS Chem Biol. 1 (2006) 766-79
Characterization of the beta-methylaspartate-alpha-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway.
Beck ZQ, Burr DA, Sherman DH
[PMID: 17600793]Chembiochem. 8 (2007) 1373-5
Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity.
Ding Y, Seufert WH, Beck ZQ, Sherman DH
[PMID: 18366166]J Am Chem Soc. 130 (2008) 5492-8
Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.
Ding Y, Rath CM, Bolduc KL, Hakansson K, Sherman DH
[PMID: 21823639]J Am Chem Soc. 133 (2011) 14492-5

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Cryptophycin 1
Genomic nucleotide sequence
58 KB
Nucleotide sequences of the coding regions
40 KB
Translation of the coding sequences
14 KB
List of genes/ORFs
1005 B

 

 
GenBank format
97 KB

close this sectionHistory

  • 2013-09-04[Update]
  • 2012-03-28[Release]