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Cluster information : Tautomycin


close this sectionCompound

Entry nameTautomycin
PKS TypeTypeI modular
Starter Unitisobutyryl-CoA
Chain Length13
Sugar Unitnone
ClassificationTetronic Acid Derivative
ActivityAntibacterial
Antifungal
Antitumor
CompositionC41H66O13
Tautomycin

close this sectionOriginal source


close this sectionPKS/NRPS Module

Tauto_00110
ttmJ
0
1 methoxymalonyl-ACP
2 malonyl-CoA
3 methylmalonyl-CoA
4 malonyl-CoA
5 methylmalonyl-CoA
6 methylmalonyl-CoA
Tauto_00100
ttmI
7 malonyl-CoA
8 malonyl-CoA
9 methylmalonyl-CoA
Tauto_00090
ttmH
10 malonyl-CoA
11 methylmalonyl-CoA
12 malonyl-CoA
AT104..421
ACP470..540
KS563..936
AT1092..1413
dh1461..1626
KR1912..2092
ACP2188..2258
KS2283..2657
AT2816..3124
KR3425..3605
ACP3709..3779
KS3802..4174
AT4329..4642
dh4690..4856
kr5145..5315
ACP5396..5466
KS5491..5867
AT6025..6336
dh6383..6544
KR6828..7006
ACP7103..7177
KS7199..7574
AT7743..8059
DH8106..8272
ER8594..8900
KR8910..9089
ACP9190..9260
KS9283..9651
AT9815..10128
KR10429..10609
ACP10709..10783
KS35..411
AT572..883
DH929..1094
ER1391..1697
KR1707..1887
ACP1981..2055
KS2078..2451
AT2611..2902
kr3221..3401
ACP3505..3575
KS3598..3973
AT4127..4443
DH4490..4658
ER4970..5272
KR5282..5462
ACP5559..5633
KS34..411
AT571..883
dh931..1084
KR1381..1561
ACP1662..1732
KS1755..2129
AT2281..2595
DH2644..2814
ER3125..3431
KR3441..3620
ACP3717..3791
KS3814..4190
AT4340..4651
dh4697..4866
kr5150..5316
ACP5400..5470
TE5548..5766

close this sectionReference

Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus.
Li W, Ju J, Osada H, Shen B
[PMID: 16707708]J Bacteriol. 188 (2006) 4148-52
Characterization of the tautomycin biosynthetic gene cluster from Streptomyces spiroverticillatus unveiling new insights into dialkylmaleic anhydride and polyketide biosynthesis.
Li W, Ju J, Rajski SR, Osada H, Shen B
[PMID: 18708355]J Biol Chem. 283 (2008) 28607-17
Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity.
Ju J, Li W, Yuan Q, Peters NR, Hoffmann FM, Rajski SR, Osada H, Shen B
[PMID: 19281218]Org Lett. 11 (2009) 1639-42

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Tautomycin
Genomic nucleotide sequence
95 KB
Nucleotide sequences of the coding regions
92 KB
Translation of the coding sequences
32 KB
List of genes/ORFs
4 KB

 

 
GenBank format
177 KB

close this sectionHistory

  • 2012-06-04[Release]