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Cluster information : Meridamycin


close this sectionCompound

Entry nameMeridamycin
PKS TypePKS-NRPS hybrid
Starter Unitmalonyl-CoA
Chain Length15
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityNeuroprotective
Non-immunosuppressive
CompositionC45H75NO12
Meridamycin

close this sectionOriginal source

Organism
StrainDSM 4137
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Merid_00020
merA
0 malonyl-CoA
1 methylmalonyl-CoA
2 methylmalonyl-CoA
3 malonyl-CoA
Merid_00030
merB
4 ethylmalonyl-CoA
5 methylmalonyl-CoA
6 methylmalonyl-CoA
7 methylmalonyl-CoA
Merid_00040
merC
8 malonyl-CoA
9 malonyl-CoA
10 methylmalonyl-CoA
11 malonyl-CoA
12 malonyl-CoA
13 methylmalonyl-CoA
14 malonyl-CoA
Merid_00010
merP
15
16
KSQ24..412
AT577..897
ACP974..1044
KS1067..1440
AT1594..1903
KR2158..2334
ACP2432..2502
KS2530..2901
AT3047..3354
DH3396..3554
KR3827..4004
ACP4107..4177
KS4198..4574
AT4723..4991
KR5304..5480
ACP5568..5638
KS34..406
AT556..876
DH921..1083
KR1360..1540
ACP1640..1710
KS1734..2110
AT2292..2600
KR2944..3120
ACP3226..3296
KS3321..3699
AT3851..4160
DH4208..4368
ER4712..5016
KR5025..5202
ACP5300..5370
KS5393..5770
AT5918..6225
DH6272..6431
KR6747..6924
ACP7024..7094
KS50..426
AT572..842
KR1145..1321
ACP1415..1485
KS1508..1879
AT2023..2292
KR2595..2771
ACP2857..2927
KS2950..3319
AT3471..3780
KR4110..4286
ACP4392..4462
KS4485..4862
AT5007..5275
KR5581..5757
ACP5852..5922
KS5944..6320
AT6466..6718
KR7064..7237
ACP7330..7400
KS7421..7798
AT7993..8324
DH8369..8536
ER8875..9173
KR9183..9360
ACP9465..9535
KS9559..9933
AT10090..10406
dh10451..10597
kr10917..11072
ACP11133..11203
C40..338
A524..967
PCP1056..1123
C1144..1437

close this sectionReference

Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.
Sun Y, Hong H, Samborskyy M, Mironenko T, Leadlay PF, Haydock SF
[PMID: 17159202]Microbiology. 152 (2006) 3507-15

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Meridamycin
Genomic nucleotide sequence
93 KB
Nucleotide sequences of the coding regions
81 KB
Translation of the coding sequences
27 KB
List of genes/ORFs
625 B

 

 
GenBank format
158 KB

close this sectionHistory

  • 2012-03-28[Release]