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Cluster information : Rubradirin


close this sectionCompound

Entry nameRubradirin
Moiety descriptionA: prorubransarol
B: aminocoumarin moiety
PKS TypeA: TypeI modular
B: other
Starter Unit3-amino-5-hydroxybenzoic acid (AHBA)
Chain LengthA: 7
Sugar UnitD-rubranitrose
ClassificationAnsamycin
ActivityAntibacterial
CompositionC48H46N4O20
Rubradirin

close this sectionOriginal source


close this sectionPKS/NRPS Module

ARubra_00070
rubA
0
1 methylmalonyl-CoA
2 malonyl-CoA
3 methylmalonyl-CoA
Rubra_00380
rubB
4 methylmalonyl-CoA
5 malonyl-CoA
6 methylmalonyl-CoA
BRubra_00400
rubC1
1 tyrosine
A38..445
PCP908..982
KS1002..1378
AT1537..1855
dh1904..2085
KR2304..2484
ACP2595..2665
KS2694..3069
AT3232..3555
ACP3631..3703
KS3725..4102
AT4269..4594
kr4914..5091
ACP5196..5266
KS35..411
AT564..882
DH931..1094
KR1394..1574
ACP1679..1749
KS1776..2150
AT2306..2623
dh2670..2819
KR3097..3277
ACP3376..3450
KS3472..3833
AT3982..4302
dh4349..4494
kr4712..4914
ACP4964..5034
A757..1148
PCP1235..1301

close this sectionReference

Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.
Sohng JK, Oh TJ, Lee JJ, Kim CG
[PMID: 9387157]Mol Cells. 7 (1997) 674-81
Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris.
Lamichhane J, Liou K, Lee HC, Kim CG, Sohng JK
[PMID: 16614891]Biotechnol Lett. 28 (2006) 545-53
Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061.
Kim CG, Lamichhane J, Song KI, Nguyen VD, Kim DH, Jeong TS, Kang SH, Kim KW, Maharjan J, Hong YS, Kang JS, Yoo JC, Lee JJ, Oh TJ, Liou K, Sohng JK
[PMID: 18080113]Arch Microbiol. 189 (2008) 463-73
A unifying nitrososynthase involved in nitrosugar biosynthesis.
Hu Y, Al-Mestarihi A, Grimes CL, Kahne D, Bachmann BO
[PMID: 18983146]J Am Chem Soc. 130 (2008) 15756-7
Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains.
Boll B, Hennig S, Xie C, Sohng JK, Heide L
[PMID: 21448870]Chembiochem. 12 (2011) 1105-14
A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation.
Boll B, Heide L
[PMID: 23225745]Chembiochem. 14 (2013) 43-4
Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.
Al-Mestarihi A, Romo A, Liu HW, Bachmann BO
[PMID: 23885759]J Am Chem Soc. 135 (2013) 11457-60

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Rubradirin
Genomic nucleotide sequence
107 KB
Nucleotide sequences of the coding regions
98 KB
Translation of the coding sequences
36 KB
List of genes/ORFs
9 KB

 

 
GenBank format
207 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2014-06-25[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-03-28[Release]