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Cluster information : Epothilone


close this sectionCompound

Entry nameEpothilone
PKS TypePKS-NRPS hybrid
Starter Unitacetyl-CoA
Chain Length10
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAntitumor
CompositionA: C26H39NO6S
Epothilone

close this sectionOriginal source

Organism
StrainSo ce90
Contig
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close this sectionPKS/NRPS Module

Epoth_00060
epoA
0 malonyl-CoA
Epoth_00070
epoP
1
Epoth_00080
epoB
2 methylmalonyl-CoA
not conserved YASHS(Y->V)
Epoth_00090
epoC
3 malonyl-CoA
4 malonyl-CoA for Epothilone A
methylmalonyl-CoA for Epothilone B
5 malonyl-CoA
6 methylmalonyl-CoA
not conserved YASHS(Y->V)
Epoth_00100
epoD
7 methylmalonyl-CoA
not conserved YASHS(Y->V)
8 methylmalonyl-CoA
not conserved YASHS(Y->V)
Epoth_00110
epoE
9 malonyl-CoA
KS12..388
AT543..821
er956..1271
ACP1313..1382
C71..364
A550..953
OX1058..1223
PCP1317..1384
KS8..384
AT538..854
DH903..1071
KR1441..1621
ACP1721..1790
KS39..408
AT563..848
KR1149..1338
ACP1433..1503
KS1525..1898
AT2056..2341
KR2647..2836
ACP2932..3002
KS3023..3397
AT3555..3861
DH3917..4083
ER4416..4718
KR4731..4910
ACP5005..5079
KS5102..5477
AT5630..5948
DH5998..6166
ER6525..6836
KR6859..7039
ACP7139..7208
KS35..405
AT560..876
KR1145..1334
ACP1430..1500
KS1522..1896
AT2052..2368
dh2421..2588
MT2863..2963
kr3393..3573
ACP3669..3742
KS32..402
AT556..834
DH921..1089
er1461..1789
KR1812..1992
ACP2092..2161
TE2200..2419

close this sectionReference

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90.
Molnar I, Schupp T, Ono M, Zirkle R, Milnamow M, Nowak-Thompson B, Engel N, Toupet C, Stratmann A, Cyr DD, Gorlach J, Mayo JM, Hu A, Goff S, Schmid J, Ligon JM
[PMID: 10662695]Chem Biol. 7 (2000) 97-109
Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton.
Gerth K, Steinmetz H, Hofle G, Reichenbach H
[PMID: 11217802]J Antibiot (Tokyo). 53 (2000) 1373-7

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Epothilone
Genomic nucleotide sequence
69 KB
Nucleotide sequences of the coding regions
68 KB
Translation of the coding sequences
23 KB
List of genes/ORFs
2 KB

 

 
GenBank format
128 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2012-03-28[Release]