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Cluster information : Benastatin


close this sectionCompound

Entry nameBenastatin
PKS TypeTypeII
Starter Unithexanoyl-ACP
Chain Length12
Sugar Unitnone
ClassificationPentangular
ActivityAntibacterial
Apoptosis inducer
glutathione-S-transferase(GST) inhibitor
CompositionA: C30H28O7
Benastatin

close this sectionOriginal source

Organism
StrainA2991200
Contig
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close this sectionPKS/NRPS Module

KS13..335
KS5..376
CLF3..359
ACP5..79

close this sectionReference

Molecular analysis of the benastatin biosynthetic pathway and genetic engineering of altered fatty acid-polyketide hybrids.
Xu Z, Schenk A, Hertweck C
[PMID: 17439117]J Am Chem Soc. 129 (2007) 6022-30
Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways.
Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C
[PMID: 17625850]J Am Chem Soc. 129 (2007) 9306-12
Geminal bismethylation prevents polyketide oxidation and dimerization in the benastatin pathway.
Schenk A, Xu Z, Pfeiffer C, Steinbeck C, Hertweck C
[PMID: 17691088]Angew Chem Int Ed Engl. 46 (2007) 7035-8
Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.
Xu Z, Metsa-Ketela M, Hertweck C
[PMID: 19047004]J Biotechnol. 140 (2009) 107-13

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Benastatin
Genomic nucleotide sequence
18 KB
Nucleotide sequences of the coding regions
17 KB
Translation of the coding sequences
6 KB
List of genes/ORFs
2 KB

 

 
GenBank format
39 KB

close this sectionHistory

  • 2013-05-28[Update]
  • 2013-01-16[Release]