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Cluster information : Pyrrolomycin


close this sectionCompound

Entry namePyrrolomycin
PKS TypePKS-NRPS hybrid
Starter UnitL-proline
Chain Length3
Sugar Unitnone
ClassificationPyrrole Antibiotic
ActivityAntibacterial [A, B, C, D, E]
Antifungal [A, B, D]
Immunopotentiator [B]
Toxic [C, D]
CompositionA: C4H2Cl2N2O2
B: C11H6Cl4N2O3
C: C11H5Cl4NO2
D: C11H4Cl5NO2
E: C10H5Cl3N2O3
J: C12H6Cl5NO2
Dioxa: C12H6Cl4N2O4
Pyrrolomycin

close this sectionOriginal source

Organism
StrainATCC 31673 (=NBRC 14294)
Contig
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close this sectionPKS/NRPS Module

0
Pyrlo_00250
pyr25
1 malonyl-CoA
not conserved HAFHS(H->Y)
2
Pyrlo_00240
pyr24
3 malonyl-CoA
A9..396
PCP16..82
KS28..402
AT562..879
ACP1008..1078
KS1149..1523
AT1719..1810
KR
ACP2018..2086
KS42..417
AT572..870
KR1454..1650
ACP1743..1816
R1868..2226

close this sectionReference

Cloning and characterization of the pyrrolomycin biosynthetic gene clusters from Actinosporangium vitaminophilum ATCC 31673 and Streptomyces sp. strain UC 11065.
Zhang X, Parry RJ
[PMID: 17158935]Antimicrob Agents Chemother. 51 (2007) 946-57
Draft Genome Sequence of Streptomyces vitaminophilus ATCC 31673, a Producer of Pyrrolomycin Antibiotics, Some of Which Contain a Nitro Group.
Mahan KM, Klingeman DM, Hettich RL, Parry RJ, Graham DE
[PMID: 26798098]Genome Announc. 4 (2016)

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Pyrrolomycin
Genomic nucleotide sequence
56 KB
Nucleotide sequences of the coding regions
52 KB
Translation of the coding sequences
19 KB
List of genes/ORFs
5 KB

 

 
GenBank format
112 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2012-10-02[Update]
  • 2012-06-04[Release]