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Cluster information : Megalomicin


close this sectionCompound

Entry nameMegalomicin
PKS TypeTypeI modular
Starter Unitpropionyl-CoA
Chain Length7
Sugar UnitL-mycarose
D-desosamine
L-megosamine
ClassificationMacrolide
ActivityAntibacterial
Antiparasitic
Antiviral
CompositionA: C44H80N2O15
Megalomicin

close this sectionOriginal source


close this sectionPKS/NRPS Module

Megalo_00120
megAI
0
1 methylmalonyl-CoA
2 methylmalonyl-CoA
Megalo_00130
megAII
3 methylmalonyl-CoA
4 methylmalonyl-CoA
Megalo_00140
megAIII
5 methylmalonyl-CoA
6 methylmalonyl-CoA
AT109..424
ACP464..534
KS557..930
AT1083..1405
KR1661..1840
ACP1936..2006
KS2030..2398
AT2566..2884
KR3115..3293
ACP3389..3462
KS31..406
AT560..880
kr1124..1291
ACP1391..1461
KS1483..1856
AT2011..2330
DH2374..2537
ER2823..3123
KR3133..3313
ACP3409..3479
KS39..403
AT574..893
KR1137..1315
ACP1412..1482
KS1507..1878
AT2044..2356
KR2583..2759
ACP2847..2917
TE2989..3196

close this sectionReference

Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
Volchegursky Y, Hu Z, Katz L, McDaniel R
[PMID: 10972798]Mol Microbiol. 37 (2000) 752-62
Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli.
Murli S, Piagentini M, McDaniel R, Hutchinson CR
[PMID: 15595843]Biochemistry. 43 (2004) 15884-90
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.
Peiru S, Menzella HG, Rodriguez E, Carney J, Gramajo H
[PMID: 15870344]Appl Environ Microbiol. 71 (2005) 2539-47
In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.
Rodriguez E, Peiru S, Carney JR, Gramajo H
[PMID: 16514147]Microbiology. 152 (2006) 667-73
Characterization of the heterodimeric MegBIIa:MegBIIb aldo-keto reductase involved in the biosynthesis of L-mycarose from Micromonospora megalomicea.
Peiru S, Rodriguez E, Tran CQ, Carney JR, Gramajo H
[PMID: 17571859]Biochemistry. 46 (2007) 8100-9
TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.
Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H
[PMID: 20418422]Appl Environ Microbiol. 76 (2010) 3869-77

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Megalomicin
Genomic nucleotide sequence
48 KB
Nucleotide sequences of the coding regions
48 KB
Translation of the coding sequences
17 KB
List of genes/ORFs
3 KB

 

 
GenBank format
94 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-03-28[Release]