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Cluster information : Lasalocid


close this sectionCompound

Entry nameLasalocid
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length12
Sugar Unitnone
ClassificationPolyether
ActivityAntibacterial
Ionophore
CompositionA: C34H54O8
Lasalocid2

close this sectionOriginal source

Organism
StrainATCC 31180
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Lasal2_00160
lasAI
0 malonyl-CoA
1 ethylmalonyl-CoA
2 malonyl-CoA
Lasal2_00170
lasAII
3 ethylmalonyl-CoA
4 methylmalonyl-CoA
5 ethylmalonyl-CoA
Lasal2_00180
lasAIII
6 methylmalonyl-CoA
Lasal2_00190
lasAIV
7 methylmalonyl-CoA
Lasal2_00200
lasAV
8 malonyl-CoA
9 malonyl-CoA
Lasal2_00210
lasAVI
10 methylmalonyl-CoA
Lasal2_00220
lasAVII
11 malonyl-CoA
KSQ17..381
AT536..858
ACP959..1029
KS1052..1428
AT1581..1892
DH1940..2108
KR2476..2656
ACP2762..2832
KS2857..3233
AT3385..3693
DH3739..3900
ER4240..4533
KR4543..4723
ACP4832..4902
KS34..410
AT565..876
DH920..1085
KR1414..1592
ACP1693..1767
KS1789..2164
AT2322..2640
DH2689..2863
ER3179..3471
KR3481..3661
ACP3766..3836
KS3860..4236
AT4388..4699
KR5020..5199
ACP5304..5374
KS35..411
AT563..882
ACP954..1024
KS38..414
AT566..885
KR1201..1381
ACP1488..1563
KS35..411
AT564..872
DH917..1086
ER1443..1736
KR1746..1926
ACP2032..2102
KS2126..2502
AT2654..2957
kr3323..3423
ACP3519..3589
KS39..415
AT577..894
dh944..1108
KR1435..1615
ACP1720..1790
KS35..411
AT566..868
ACP937..1007
TE1105..1307

close this sectionReference

Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure.
Smith L, Hong H, Spencer JB, Leadlay PF
[PMID: 19025863]Chembiochem. 9 (2008) 2967-75
Insights into lasalocid A ring formation by chemical chain termination in vivo.
Tosin M, Smith L, Leadlay PF
[PMID: 22025396]Angew Chem Int Ed Engl. 50 (2011) 11930-3

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Lasalocid
Genomic nucleotide sequence
112 KB
Nucleotide sequences of the coding regions
105 KB
Translation of the coding sequences
37 KB
List of genes/ORFs
6 KB

 

 
GenBank format
211 KB

close this sectionHistory

  • 2014-06-25[Update]
  • 2014-03-10[Release]