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Cluster information : Myxalamid


close this sectionCompound

Entry nameMyxalamid
PKS TypePKS-NRPS hybrid
Starter UnitMyxalamid A: 2-methylbutyryl-CoA
Myxalamid B: isobutyryl-CoA
Myxalamid C: propionyl-CoA
Myxalamid D: acetyl-CoA
Chain Length8
Sugar Unitnone
ClassificationLinear Polyene
Peptide-Polyketide Hybrid
ActivityAntifungal
Antibacterial
CompositionMyxalamid A: C26H41NO3
Myxalamid B: C25H39NO3
Myxalamid C: C24H37NO3
Myxalamid D: C23H35NO3
Myxalamid

close this sectionOriginal source

Organism
StrainSga15
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Myxa_00090
mxaF
0
1
2-methylbutyryl-CoA for Myxalamid A
isobutyryl-CoA for Myxalamid B
propionyl-CoA for Myxalamid C
acetyl-CoA for Myxalamid D
methylmalonyl-CoA
not conserved YASHS(Y->V)
Myxa_00080
mxaE
2 methylmalonyl-CoA
not conserved YASHS(Y->V)
Myxa_00070
mxaD
3 methylmalonyl-CoA
not conserved YASHS(Y->V)
Myxa_00060
mxaC
4 malonyl-CoA
not conserved HAFHS
5 malonyl-CoA
not conserved HAFHS(H->Y)
6 malonyl-CoA
Myxa_00050
mxaB1
7 methylmalonyl-CoA
not conserved YASHS(Y->V)
Myxa_00040
mxaB2
7
Myxa_00030
mxaA
8
ACP15..84
KS102..478
AT623..940
AT1060..1371
DH1426..1593
KR1967..2146
ACP2246..2315
KS36..411
AT562..868
dh923..1092
KR1453..1639
ACP1737..1807
KS20..396
AT550..866
DH911..1075
KR1442..1621
ACP1717..1790
KS36..405
AT559..877
DH922..1096
KR1466..1645
ACP1739..1812
KS1851..2217
AT2372..2689
KR2988..3181
ACP3281..3351
KS3374..3749
AT3903..4219
DH4263..4432
KR4795..4973
ACP5071..5141
KS37..413
AT569..879
DH8..180
er
KR848..1028
ACP1124..1197
C73..372
A563..956
PCP1042..1109
R1150..1509

close this sectionReference

Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.
Silakowski B, Nordsiek G, Kunze B, Blocker H, Muller R
[PMID: 11182319]Chem Biol. 8 (2001) 59-69
Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B.
Bode HB, Meiser P, Klefisch T, Cortina NS, Krug D, Gohring A, Schwar G, Mahmud T, Elnakady YA, Muller R
[PMID: 17955482]Chembiochem. 8 (2007) 2139-44
Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.
Barajas JF, Phelan RM, Schaub AJ, Kliewer JT, Kelly PJ, Jackson DR, Luo R, Keasling JD, Tsai SC
[PMID: 26235055]Chem Biol. 22 (2015) 1018-29

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Myxalamid
Genomic nucleotide sequence
50 KB
Nucleotide sequences of the coding regions
50 KB
Translation of the coding sequences
17 KB
List of genes/ORFs
1 KB

 

 
GenBank format
95 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2012-03-28[Release]