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Cluster information : Mycolactone


close this sectionCompound

Entry nameMycolactone
Moiety descriptionA: mycolactone core
B: side chain
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length18
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityToxic
Immunosuppressive
CompositionA/B: C44H70O9
Mycolactone

close this sectionOriginal source

Organism
StrainAgy99
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

AMUP_00400
mlsA1
0 malonyl-CoA
1 malonyl-CoA
2 methylmalonyl-CoA
not conserved YASHS(A->P)
3 methylmalonyl-CoA
not conserved YASHS(A->P)
4 methylmalonyl-CoA
not conserved YASHS(A->P)
5 malonyl-CoA
6 methylmalonyl-CoA
not conserved YASHS(A->P)
7 methylmalonyl-CoA
not conserved YASHS(A->P)
8 malonyl-CoA
MUP_00390
mlsA2
9 malonyl-CoA
BMUP_00320
mlsB
0 malonyl-CoA
1 malonyl-CoA
2 malonyl-CoA
3 methylmalonyl-CoA
not conserved YASHS(A->P)
4 malonyl-CoA
5 methylmalonyl-CoA
not conserved YASHS(A->P)
6 methylmalonyl-CoA
not conserved YASHS(A->P)
7 malonyl-CoA
KSQ19..390
AT567..889
dh932..1105
KR1444..1624
ACP1724..1794
KS1817..2190
AT2372..2694
dh2737..2910
KR3249..3429
ACP3529..3599
KS3622..3995
AT4177..4499
dh4542..4715
er5057..5360
KR5370..5550
ACP5650..5720
KS5743..6116
AT6298..6620
DH6663..6836
KR7175..7355
ACP7455..7525
KS7547..7920
AT8096..8418
DH8461..8634
ER8976..9279
KR9289..9469
ACP9569..9639
KS9662..10035
AT10204..10517
KR10830..11006
ACP11108..11178
KS11201..11574
AT11750..12072
DH12115..12288
KR12621..12801
ACP12901..12971
KS12994..13367
AT13543..13865
DH13908..14081
ER14423..14726
KR14736..14916
ACP15016..15086
KS15108..15481
AT15663..15985
dh16028..16201
KR16542..16722
ACP16822..16892
KS35..408
AT590..912
DH955..1128
ER1470..1773
KR1783..1963
ACP2063..2133
KSQ19..390
AT567..889
dh932..1105
KR1444..1624
ACP1724..1794
KS1817..2190
AT2359..2672
KR2985..3161
ACP3263..3333
KS3356..3729
AT3898..4211
KR4524..4700
ACP4802..4872
KS4895..5268
AT5444..5766
DH5809..5982
KR6321..6501
ACP6601..6671
KS6694..7067
AT7243..7565
DH7608..7781
KR8120..8300
ACP8400..8470
KS8493..8866
AT9042..9364
DH9407..9580
KR9919..10099
ACP10199..10269
KS10292..10665
AT10841..11163
DH11206..11379
KR11718..11898
ACP11998..12068
KS12091..12464
AT12640..12962
DH13005..13178
KR13517..13697
ACP13797..13867

close this sectionReference

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST
[PMID: 14736915]Proc Natl Acad Sci U S A. 101 (2004) 1345-9
Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.
Coutanceau E, Marsollier L, Brosch R, Perret E, Goossens P, Tanguy M, Cole ST, Small PL, Demangel C
[PMID: 16008585]Cell Microbiol. 7 (2005) 1187-96
The unusual macrocycle forming thioesterase of mycolactone.
Meier JL, Barrows-Yano T, Foley TL, Wike CL, Burkart MD
[PMID: 18493665]Mol Biosyst. 4 (2008) 663-71
History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease).
Chany AC, Tresse C, Casarotto V, Blanchard N
[PMID: 24178858]Nat Prod Rep. 30 (2013) 1527-67

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Mycolactone
Genomic nucleotide sequence
176 KB
Nucleotide sequences of the coding regions
167 KB
Translation of the coding sequences
58 KB
List of genes/ORFs
8 KB

 

 
GenBank format
308 KB

close this sectionHistory

  • 2014-03-10[Update]
  • 2012-10-02[Update]
  • 2012-03-28[Release]