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Cluster information : Streptolydigin


close this sectionCompound

Entry nameStreptolydigin
PKS TypePKS-NRPS hybrid
Starter Unitmalonyl-CoA
Chain Length8
Sugar UnitL-rhodinose
ClassificationTetramic Acid
ActivityAntibacterial
CompositionC32H44N2O9
Streptolydigin

close this sectionOriginal source

Organism
StrainNRRL 2433 (=NBRC 13058)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Strply_00310
slgA1
0 malonyl-CoA
1 methylmalonyl-CoA
2 malonyl-CoA
3 methylmalonyl-CoA
Strply_00300
slgA2
4 methylmalonyl-CoA
5 methylmalonyl-CoA
Strply_00290
slgA3
6 malonyl-CoA
7 malonyl-CoA
Strply_00040
slgN2
8
Strply_00170
slgN1
8
KSQ29..394
AT559..870
ACP954..1032
KS1069..1445
AT1610..1925
KR2240..2418
ACP2524..2594
KS2622..2999
AT3208..3519
KR3807..3985
ACP4096..4166
KS4199..4576
AT4743..5062
DH5111..5302
KR5693..5891
ACP6014..6084
KS51..426
AT590..905
KR1262..1442
ACP1560..1630
KS1656..2031
AT2193..2508
DH2557..2725
KR3099..3270
ACP3377..3447
KS39..375
AT546..871
DH922..1089
KR1458..1629
ACP1736..1806
KS1837..2213
AT2377..2695
kr3075..3253
ACP3366..3436
C17..298
A497..552
PCP636..703
A99..496

close this sectionReference

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.
Olano C, Gomez C, Perez M, Palomino M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 19875077]Chem Biol. 16 (2009) 1031-44
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.
Horna DH, Gomez C, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 21398531]J Bacteriol. 193 (2011) 2647-51
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.
Gomez C, Horna DH, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 21665968]J Bacteriol. 193 (2011) 4214-23
Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin.
Gomez C, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 22569159]J Antibiot (Tokyo). (2012)
Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.
Gomez C, Horna DH, Olano C, Mendez C, Salas JA
[PMID: 22726958]Microb Biotechnol. (2012)
Three pathway-specific regulators control streptolydigin biosynthesis inStreptomyces lydicus.
Gomez C, Olano C, Mendez C, Salas JA
[PMID: 22820841]Microbiology. (2012)
Structural Basis of the Interaction of MbtH-Like Proteins, Putative Regulators of Non-Ribosomal Peptide Biosynthesis, with Adenylating Enzymes.
Herbst DA, Boll B, Zocher G, Stehle T, Heide L
[PMID: 23192349]J Biol Chem. (2012)
Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis.
Gui C, Li Q, Mo X, Qin X, Ma J, Ju J
[PMID: 25621700]Org Lett. 17 (2015) 628-31

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Streptolydigin
Genomic nucleotide sequence
82 KB
Nucleotide sequences of the coding regions
81 KB
Translation of the coding sequences
29 KB
List of genes/ORFs
6 KB

 

 
GenBank format
158 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-01-16[Update]
  • 2012-10-02[Update]
  • 2012-08-03[Release]