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Cluster information : Meilingmycin


close this sectionCompound

Entry nameMeilingmycin
PKS TypeTypeI modular
Starter UnitMeilingmycins A, B, D, E: malonyl-CoA
Meilingmycin C: methylmalonyl-CoA
Chain Length13
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAnthelmintic
CompositionMeilingmycin A: C36H50O9
Meilingmycin

close this sectionOriginal source

Organism
StrainNS3226
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Meili_00790
meiA1
0 malonyl-CoA for Meilingmycins A, B, D, and E
methylmalonyl-CoA for Meilingmycin C
1 methylmalonyl-CoA
not conserved YASHS(S->C)
2 malonyl-CoA
not conserved HAFHS(H->G)
Meili_00240
meiA2
3 malonyl-CoA
not conserved HAFHS(H->G)
4 malonyl-CoA
not conserved HAFHS(H->G)
5 malonyl-CoA
not conserved HAFHS(H->G)
6 methylmalonyl-CoA
not conserved YASHS(S->C)
Meili_00310
meiA3
7 methylmalonyl-CoA
not conserved YASHS(S->C)
8 malonyl-CoA
not conserved HAFHS(H->G)
9 methylmalonyl-CoA
not conserved YASHS(S->C)
Meili_00270
meiA4
10 malonyl-CoA
11 methylmalonyl-CoA
not conserved YASHS(Y->W)
12 malonyl-CoA
AT93..411
ACP475..546
KS577..954
AT1113..1431
KR1753..1933
ACP2032..2102
KS2138..2517
AT2674..2998
DH3052..3224
ER3576..3882
KR3892..4072
ACP4175..4245
KS33..409
AT564..879
ACP949..1019
KS1042..1417
AT1576..1891
KR2204..2384
ACP2487..2557
KS2581..2956
AT3111..3426
KR3693..3874
ACP3978..4048
KS4078..4454
AT4625..4943
DH4994..5174
KR5523..5703
ACP5815..5885
KS39..414
AT588..906
DH957..1133
ER1477..1779
KR1789..1969
ACP2070..2140
KS2167..2543
AT2698..3013
DH3061..3236
KR3574..3754
ACP3858..3928
KS3955..4330
AT4490..4808
DH4859..5037
KR5380..5560
ACP5661..5731
KS36..414
AT572..910
kr1213..1392
ACP1495..1565
KS1589..1965
AT2122..2439
kr2738..2891
ACP2999..3069
KS3093..3467
AT3650..3993
DH4045..4232
KR4603..4783
ACP4898..4968
TE5067..5269

close this sectionReference

Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.
He Y, Sun Y, Liu T, Zhou X, Bai L, Deng Z
[PMID: 20348291]Appl Environ Microbiol. 76 (2010) 3283-92
Spiroketal formation and modification in avermectin biosynthesis involves a dual activity of AveC.
Sun P, Zhao Q, Yu F, Zhang H, Wu Z, Wang Y, Wang Y, Zhang Q, Liu W
[PMID: 23294008]J Am Chem Soc. 135 (2013) 1540-8

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Meilingmycin
Genomic nucleotide sequence
187 KB
Nucleotide sequences of the coding regions
183 KB
Translation of the coding sequences
64 KB
List of genes/ORFs
9 KB

 

 
GenBank format
351 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2013-05-28[Update]
  • 2012-03-28[Release]