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Cluster information : Chromomycin

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Entry nameChromomycin
PKS TypeTypeII
Starter Unitacetyl-CoA
Chain Length10
Sugar UnitD-olivose
ClassificationAureolic acid
CompositionA3: C57H82O26

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StrainATCC 13273 (=NBRC 3746)
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Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.
Menendez N, Nur-e-Alam M, Brana AF, Rohr J, Salas JA, Mendez C
[PMID: 15112992]Chem Biol. 11 (2004) 21-32
Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus.
Menendez N, Nur-E-Alam M, Brana AF, Rohr J, Salas JA, Mendez C
[PMID: 15255901]Mol Microbiol. 53 (2004) 903-15
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.
Menendez N, Nur-e-Alam M, Fischer C, Brana AF, Salas JA, Rohr J, Mendez C
[PMID: 16391039]Appl Environ Microbiol. 72 (2006) 167-77
Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis.
Menendez N, Brana AF, Salas JA, Mendez C
[PMID: 17768249]Microbiology. 153 (2007) 3061-70
Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.
Bosserman MA, Florez AB, Shaaban KA, Brana AF, Salas JA, Mendez C, Rohr J
[PMID: 21244022]Biochemistry. 50 (2011) 1421-8
The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.
Garcia B, Gonzalez-Sabin J, Menendez N, Brana AF, Nunez LE, Moris F, Salas JA, Mendez C
[PMID: 21342468]Microb Biotechnol. 4 (2011) 226-38

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Compound nameGenomic
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Genomic nucleotide sequence
42 KB
Nucleotide sequences of the coding regions
42 KB
Translation of the coding sequences
16 KB
List of genes/ORFs
5 KB


GenBank format
90 KB

close this sectionHistory

  • 2013-01-16[Release]