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Cluster information : Chromomycin


close this sectionCompound

Entry nameChromomycin
PKS TypeTypeII
Starter Unitacetyl-CoA
Chain Length10
Sugar UnitD-olivose
4'-O-acetyl-D-oliose
4'-O-acetyl-L-chromose
4'-O-methyl-D-oliose
ClassificationAureolic acid
ActivityAntibacterial
Antitumor
Antiviral
CompositionA3: C57H82O26
Chromomycin

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Organism
StrainATCC 13273 (=NBRC 3746)
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

KS3..375
CLF5..360
ACP3..76

close this sectionReference

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.
Menendez N, Nur-e-Alam M, Brana AF, Rohr J, Salas JA, Mendez C
[PMID: 15112992]Chem Biol. 11 (2004) 21-32
Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus.
Menendez N, Nur-E-Alam M, Brana AF, Rohr J, Salas JA, Mendez C
[PMID: 15255901]Mol Microbiol. 53 (2004) 903-15
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.
Menendez N, Nur-e-Alam M, Fischer C, Brana AF, Salas JA, Rohr J, Mendez C
[PMID: 16391039]Appl Environ Microbiol. 72 (2006) 167-77
Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis.
Menendez N, Brana AF, Salas JA, Mendez C
[PMID: 17768249]Microbiology. 153 (2007) 3061-70
Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.
Bosserman MA, Florez AB, Shaaban KA, Brana AF, Salas JA, Mendez C, Rohr J
[PMID: 21244022]Biochemistry. 50 (2011) 1421-8
The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.
Garcia B, Gonzalez-Sabin J, Menendez N, Brana AF, Nunez LE, Moris F, Salas JA, Mendez C
[PMID: 21342468]Microb Biotechnol. 4 (2011) 226-38

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Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Chromomycin
Genomic nucleotide sequence
42 KB
Nucleotide sequences of the coding regions
42 KB
Translation of the coding sequences
16 KB
List of genes/ORFs
5 KB

 

 
GenBank format
90 KB

close this sectionHistory

  • 2013-01-16[Release]