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Cluster information : Reveromycin


close this sectionCompound

Entry nameReveromycin
PKS TypeTypeI modular
Starter Unitmethylmalonyl-CoA
Chain Length13
Sugar Unitnone
ClassificationSpiroacetal structure
ActivityAntifungal
Antiosteoclastic
Compositionreveromycin A: C36H52O11
Reveromycin

close this sectionOriginal source

Organism
StrainSN-593
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Rever_00230
revC
0 methylmalonyl-CoA
1 malonyl-CoA
2 methylmalonyl-CoA
3 malonyl-CoA
Rever_00110
revA
4 butylmalonyl-CoA
isopentylmalonyl-CoA
pentylmalonyl-CoA
hexylmalonyl-CoA
5 malonyl-CoA
6 malonyl-CoA
Rever_00120
revB
7 methylmalonyl-CoA
8 malonyl-CoA
Rever_00240
revD
9 methylmalonyl-CoA
10 malonyl-CoA
11 methylmalonyl-CoA
12 malonyl-CoA
KSQ8..381
AT546..886
ACP963..1033
KS1057..1430
AT1588..1894
dh1942..2095
KR2420..2596
ACP2695..2765
KS2788..3162
AT3337..3649
DH3697..3855
KR4131..4307
ACP4410..4480
KS4503..4872
AT5035..5341
DH5389..5552
KR5853..6029
ACP6130..6200
KS37..413
AT578..900
KR1181..1361
ACP1462..1532
KS1554..1929
AT2122..2426
DH2474..2639
ER2953..3259
KR3269..3449
ACP3546..3620
KS3644..4020
AT4182..4488
KR4776..4956
ACP5052..5126
KS34..408
AT601..914
DH962..1127
ER1456..1762
KR1772..1952
ACP2049..2123
KS2147..2519
AT2705..3010
KR3297..3477
ACP3573..3647
KS35..402
AT576..888
DH936..1094
KR1404..1580
ACP1681..1751
KS1774..2143
AT2329..2635
DH2684..2841
KR3141..3313
ACP3410..3484
KS3509..3883
AT4054..4366
KR4650..4830
ACP4928..4998
KS5022..5397
AT5565..5871
DH5918..6074
KR6386..6558
ACP6660..6730
TE6809..7021

close this sectionReference

Reveromycin A biosynthesis uses RevG and RevJ for stereospecific spiroacetal formation.
Takahashi S, Toyoda A, Sekiyama Y, Takagi H, Nogawa T, Uramoto M, Suzuki R, Koshino H, Kumano T, Panthee S, Dairi T, Ishikawa J, Ikeda H, Sakaki Y, Osada H
[PMID: 21642985]Nat Chem Biol. 7 (2011) 461-8
Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T.
Takahashi S, Nagano S, Nogawa T, Kanoh N, Uramoto M, Kawatani M, Shimizu T, Miyazawa T, Shiro Y, Osada H
[PMID: 25258320]J Biol Chem. 289 (2014) 32446-58
Chemical and biological studies of reveromycin A.
Osada H
[PMID: 27270304]J Antibiot (Tokyo). 69 (2016) 723-730

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Reveromycin
Genomic nucleotide sequence
106 KB
Nucleotide sequences of the coding regions
103 KB
Translation of the coding sequences
35 KB
List of genes/ORFs
4 KB

 

 
GenBank format
196 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2013-09-04[Release]