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Cluster information : A40926


close this sectionCompound

Entry nameA40926
Moiety descriptionA: aglycone
B: L-3,5-dihydroxyphenylglycine(Dpg)
PKS TypeA: NRPS
B: TypeIII
Starter UnitB: malonyl-CoA
Chain LengthB: 4
Sugar UnitN-acyl-aminoglucuronic acid
6'-O-acetyl-D-mannose
ClassificationGlycopeptide(teicoplanin-type)
ActivityAntibacterial
CompositionPA: C84H88Cl2N8O30
A40926

close this sectionOriginal source

Organism
StrainATCC 39727
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

AA4092_00310
dbv25
1 L-4-hydroxyphenylglycine(Hpg)
2 tyrosine
A4092_00320
dbv26
3 L-3,5-dihydroxyphenylglycine(Dpg)
A4092_00230
dbv17
4 L-4-hydroxyphenylglycine(Hpg)
5 L-4-hydroxyphenylglycine(Hpg)
6 tyrosine
A4092_00220
dbv16
7 L-3,5-dihydroxyphenylglycine(Dpg)
BA4092_00370
dbv31
1
A37..427
PCP503..571
C602..897
A1064..1454
PCP1530..1599
E1635..2082
C13..308
A487..877
PCP953..1022
C7..301
A482..879
PCP957..1023
E1060..1493
C1502..1792
A1972..2371
PCP2454..2520
E2566..3006
C3018..3309
A3492..3886
PCP3980..4046
C15..310
A494..894
PCP976..1043
X1057..1355
TE1624..1841
CHS98..370

close this sectionReference

The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.
Sosio M, Stinchi S, Beltrametti F, Lazzarini A, Donadio S
[PMID: 12837387]Chem Biol. 10 (2003) 541-9
Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons.
Kruger RG, Lu W, Oberthur M, Tao J, Kahne D, Walsh CT
[PMID: 15664522]Chem Biol. 12 (2005) 131-40
Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis.
Donadio S, Sosio M, Stegmann E, Weber T, Wohlleben W
[PMID: 16007453]Mol Genet Genomics. 274 (2005) 40-50
A derivative of the glycopeptide A40926 produced by inactivation of the beta-hydroxylase gene in Nonomuraea sp. ATCC39727.
Stinchi S, Carrano L, Lazzarini A, Feroggio M, Grigoletto A, Sosio M, Donadio S
[PMID: 16499611]FEMS Microbiol Lett. 256 (2006) 229-35
Understanding and manipulating glycopeptide pathways: the example of the dalbavancin precursor A40926.
Sosio M, Donadio S
[PMID: 16761167]J Ind Microbiol Biotechnol. 33 (2006) 569-76
Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.
Ho JY, Huang YT, Wu CJ, Li YS, Tsai MD, Li TL
[PMID: 17044690]J Am Chem Soc. 128 (2006) 13694-5
Phosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926.
Alduina R, Lo Piccolo L, D'Alia D, Ferraro C, Gunnarsson N, Donadio S, Puglia AM
[PMID: 17873036]J Bacteriol. 189 (2007) 8120-9
A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation.
Li YS, Ho JY, Huang CC, Lyu SY, Lee CY, Huang YT, Wu CJ, Chan HC, Huang CJ, Hsu NS, Tsai MD, Li TL
[PMID: 17935335]J Am Chem Soc. 129 (2007) 13384-5
Crystal structures of lipoglycopeptide antibiotic deacetylases: implications for the biosynthesis of A40926 and teicoplanin.
Zou Y, Brunzelle JS, Nair SK
[PMID: 18559264]Chem Biol. 15 (2008) 533-45
Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.
Marcone GL, Beltrametti F, Binda E, Carrano L, Foulston L, Hesketh A, Bibb M, Marinelli F
[PMID: 20308385]Antimicrob Agents Chemother. 54 (2010) 2465-72
Improved production of A40926 by Nonomuraea sp. through deletion of a pathway-specific acetyltransferase.
Sosio M, Canavesi A, Stinchi S, Donadio S
[PMID: 20414653]Appl Microbiol Biotechnol. 87 (2010) 1633-8
Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.
Liu YC, Li YS, Lyu SY, Hsu LJ, Chen YH, Huang YT, Chan HC, Huang CJ, Chen GH, Chou CC, Tsai MD, Li TL
[PMID: 21478878]Nat Chem Biol. 7 (2011) 304-9
Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727.
Binda E, Marcone GL, Pollegioni L, Marinelli F
[PMID: 22788848]FEBS J. 279 (2012) 3203-13
Streptomyces spp. as efficient expression system for a D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance.
Binda E, Marcone GL, Berini F, Pollegioni L, Marinelli F
[PMID: 23497129]BMC Biotechnol. 13 (2013) 24
Glycopeptide antibiotic biosynthesis.
Yim G, Thaker MN, Koteva K, Wright G
[PMID: 24220108]J Antibiot (Tokyo). 67 (2014) 31-41
Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.
Marcone GL, Binda E, Carrano L, Bibb M, Marinelli F
[PMID: 24957828]Antimicrob Agents Chemother. 58 (2014) 5191-201
Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.
Lyu SY, Liu YC, Chang CY, Huang CJ, Chiu YH, Huang CM, Hsu NS, Lin KH, Wu CJ, Tsai MD, Li TL
[PMID: 25095906]J Am Chem Soc. 136 (2014) 10989-95
Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.
Liu YC, Li YS, Lyu SY, Hsu LJ, Chen YH, Huang YT, Chan HC, Huang CJ, Chen GH, Chou CC, Tsai MD, Li TL
[PMID: 25885959]Nat Chem Biol. 11 (2015) 361
Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727.
Lo Grasso L, Maffioli S, Sosio M, Bibb M, Puglia AM, Alduina R
[PMID: 25986904]J Bacteriol. 197 (2015) 2536-44

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
A40926
Genomic nucleotide sequence
90 KB
Nucleotide sequences of the coding regions
85 KB
Translation of the coding sequences
31 KB
List of genes/ORFs
7 KB

 

 
GenBank format
176 KB

close this sectionHistory

  • 2016-12-27[Release]