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Cluster information : Monensin


close this sectionCompound

Entry nameMonensin
PKS TypeTypeI modular
Starter Unitmalonyl-CoA
Chain Length13
Sugar Unitnone
ClassificationPolyether
ActivityAntibacterial
Ionophore
Antiprotozoal
CompositionA: C36H62O11
B: C35H60O11
C: C37H64O11
Monensin

close this sectionOriginal source

Organism
StrainATCC 15413
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Monen_00150
monAI
0 malonyl-CoA
1 methylmalonyl-CoA
Monen_00160
monAII
2 methylmalonyl-CoA
Monen_00170
monAIII
3 malonyl-CoA
4 methylmalonyl-CoA
Monen_00180
monAIV
5 A: ethylmalonyl-CoA
B: methylmalonyl-CoA
6 malonyl-CoA
Monen_00190
monAV
7 methylmalonyl-CoA
8 malonyl-CoA
Monen_00200
monAVI
9 malonyl-CoA
Monen_00260
monAVII
10 methylmalonyl-CoA
Monen_00250
monAVIII
11 methylmalonyl-CoA
12 methylmalonyl-CoA
Monen_00090
ksX
13
Monen_00080
acpX
13
KSQ17..381
AT553..899
ACP977..1050
KS1079..1455
AT1615..1930
dh1978..2167
kr2508..2721
ACP2818..2888
KS34..408
AT564..881
DH927..1090
ER1445..1753
KR1763..1943
ACP2049..2119
KS34..405
AT609..932
DH981..1198
KR1576..1756
ACP1873..1943
KS1975..2351
AT2507..2824
DH2873..3037
ER3364..3671
KR3681..3861
ACP3971..4041
KS60..433
AT593..910
DH959..1133
KR1449..1629
ACP1728..1798
KS1833..2209
AT2377..2696
DH2744..2910
ER3239..3545
KR3555..3735
ACP3877..3950
KS34..408
AT563..879
DH927..1097
KR1482..1662
ACP1764..1834
KS1856..2232
AT2398..2720
DH2768..2935
ER3302..3608
KR3618..3798
ACP3943..4013
KS41..416
AT582..903
dh
KR1264..1433
ACP1541..1611
KS35..411
AT568..884
KR1206..1385
ACP1486..1555
KS32..408
AT563..882
KR1202..1381
ACP1485..1555
KS1581..1958
AT2119..2436
dh2485..2652
er
KR3275..3455
ACP3559..3629
KS34..401
at632..694
ACP27..97

close this sectionReference

Production of 26-deoxymonensins A and B by Streptomyces cinnamonensis in the presence of Metyrapone.
Pospisil S, Sedmera P, Havlicek V, Tax J
[PMID: 8017935]Appl Environ Microbiol. 60 (1994) 1561-4
Engineering of complex polyketide biosynthesis--insights from sequencing of the monensin biosynthetic gene cluster.
Leadlay PF, Staunton J, Oliynyk M, Bisang C, Cortes J, Frost E, Hughes-Thomas ZA, Jones MA, Kendrew SG, Lester JB, Long PF, McArthur HA, McCormick EL, Oliynyk Z, Stark CB, Wilkinson CJ
[PMID: 11774001]J Ind Microbiol Biotechnol. 27 (2001) 360-7
Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization.
Oliynyk M, Stark CB, Bhatt A, Jones MA, Hughes-Thomas ZA, Wilkinson C, Oliynyk Z, Demydchuk Y, Staunton J, Leadlay PF
[PMID: 12940979]Mol Microbiol. 49 (2003) 1179-90
Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked.
Bhatt A, Stark CB, Harvey BM, Gallimore AR, Demydchuk YA, Spencer JB, Staunton J, Leadlay PF
[PMID: 16217816]Angew Chem Int Ed Engl. 44 (2005) 7075-8
Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis.
Gallimore AR, Stark CB, Bhatt A, Harvey BM, Demydchuk Y, Bolanos-Garcia V, Fowler DJ, Staunton J, Leadlay PF, Spencer JB
[PMID: 16632258]Chem Biol. 13 (2006) 453-60
Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin.
Harvey BM, Hong H, Jones MA, Hughes-Thomas ZA, Goss RM, Heathcote ML, Bolanos-Garcia VM, Kroutil W, Staunton J, Leadlay PF, Spencer JB
[PMID: 16897798]Chembiochem. 7 (2006) 1435-42
Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.
Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane DE, Deng Z
[PMID: 16984884]Chem Biol. 13 (2006) 945-55
Allosteric regulation of epoxide opening cascades by a pair of epoxide hydrolases in monensin biosynthesis.
Minami A, Ose T, Sato K, Oikawa A, Kuroki K, Maenaka K, Oguri H, Oikawa H
[PMID: 24320215]ACS Chem Biol. 9 (2014) 562-9
Predicted incorporation of non-native substrates by a polyketide synthase yields bioactive natural product derivatives.
Bravo-Rodriguez K, Ismail-Ali AF, Klopries S, Kushnir S, Ismail S, Fansa EK, Wittinghofer A, Schulz F, Sanchez-Garcia E
[PMID: 25044264]Chembiochem. 15 (2014) 1991-7

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Monensin
Genomic nucleotide sequence
104 KB
Nucleotide sequences of the coding regions
102 KB
Translation of the coding sequences
36 KB
List of genes/ORFs
5 KB

 

 
GenBank format
198 KB

close this sectionHistory

  • 2016-01-27[Update]
  • 2014-06-25[Update]
  • 2012-08-03[Update]
  • 2012-04-26[Release]