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Cluster information : Borrelidin


close this sectionCompound

Entry nameBorrelidin
PKS TypeTypeI iterative
Starter Unittrans-cyclopentane-1,2-dicarboxylic acid (trans-1,2-CPDA)
Chain Length9
Sugar Unitnone
ClassificationOther Macrocyclic Lactone
ActivityAngiogenesis Inhibition
Antibacterial
Antiviral
Antiproliferative
Antiprotozoal
CompositionC28H43NO6
Borrelidin

close this sectionOriginal source

Organism
StrainTü4055
Contig
Click on the icon to see Genetic map.

close this sectionPKS/NRPS Module

Borre_00150
borA1
0
Borre_00160
borA2
1 malonyl-CoA
Borre_00170
borA3
2 malonyl-CoA
3 methylmalonyl-CoA
Borre_00180
borA4
4 methylmalonyl-CoA
Borre_00190
borA5
5 methylmalonyl-CoA
Borre_00200
borA6
6 malonyl-CoA
AT322..642
ACP694..767
KS34..410
AT558..864
KR1138..1314
ACP1419..1489
KS34..410
AT560..866
DH913..1076
KR1356..1529
ACP1628..1698
KS1724..2100
AT2245..2555
DH2603..2760
KR3062..3242
ACP3336..3410
KS21..397
AT542..852
KR1168..1346
ACP1446..1516
KS60..434
AT579..894
DH941..1098
ER1409..1714
KR1724..1900
ACP2001..2071
KS37..408
AT556..862
KR1103..1278
ACP1371..1441
TE1522..1730

close this sectionReference

Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
Olano C, Wilkinson B, Moss SJ, Brana AF, Mendez C, Leadlay PF, Salas JA
[PMID: 14651102]Chem Commun (Camb). (2003) 2780-2
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions.
Olano C, Wilkinson B, Sanchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Brana AF, Martin CJ, Oliynyk M, Mendez C, Leadlay PF, Salas JA
[PMID: 15112998]Chem Biol. 11 (2004) 87-97
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: insights into nitrile formation.
Olano C, Moss SJ, Brana AF, Sheridan RM, Math V, Weston AJ, Mendez C, Leadlay PF, Wilkinson B, Salas JA
[PMID: 15186422]Mol Microbiol. 52 (2004) 1745-56
Stereoselectivity of isolated dehydratase domains of the borrelidin polyketide synthase: implications for cis double bond formation.
Vergnolle O, Hahn F, Baerga-Ortiz A, Leadlay PF, Andexer JN
[PMID: 21472957]Chembiochem. 12 (2011) 1011-4
Identification of borrelidin binding site on threonyl-tRNA synthetase.
Li M, Zhang J, Liu C, Fang B, Wang X, Xiang W
[PMID: 25128830]Biochem Biophys Res Commun. 451 (2014) 485-90
In vitro analysis of carboxyacyl substrate tolerance in the loading and first extension modules of borrelidin polyketide synthase.
Hagen A, Poust S, de Rond T, Yuzawa S, Katz L, Adams PD, Petzold CJ, Keasling JD
[PMID: 25188840]Biochemistry. 53 (2014) 5975-7
Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid.
Hagen A, Poust S, Rond Td, Fortman JL, Katz L, Petzold CJ, Keasling JD
[PMID: 26501439]ACS Synth Biol. 5 (2016) 21-7
Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD
[PMID: 26976746]Biochemistry. 55 (2016) 1677-80

close this sectionData download

Compound nameGenomic
nucleotide
sequence
Nucleotide
sequences of the
coding regions
Translation of the
coding sequences
List of genes/ORFsGBK
Borrelidin
Genomic nucleotide sequence
75 KB
Nucleotide sequences of the coding regions
74 KB
Translation of the coding sequences
27 KB
List of genes/ORFs
6 KB

 

 
GenBank format
152 KB

close this sectionHistory

  • 2016-12-27[Update]
  • 2016-01-27[Update]
  • 2014-06-25[Update]
  • 2013-05-28[Update]
  • 2012-03-28[Release]