open/close all
Cluster information : Borrelidin
Compound
| Entry name | Borrelidin |
|---|---|
| PKS Type | TypeI iterative |
| Classification | Other Macrocyclic Lactone |
| Starter Unit | cyclopentanecarboxylic acid |
| Chain Length | 9 |
| Sugar Unit | none |
| Activity | Angiogenesis Inhibition Antibacterial Antiviral Antiproliferative |
| Composition | C28H43NO6 |
Original source
| Organism | Streptomyces parvulus |
|---|---|
| Strain | Tü4055 |
| Contig | AJ580915 |
PKS/NRPS Module
| Borre_00150 borA1 | 0 |  | |
| Borre_00160 borA2 | 1 |  | malonyl-CoA |
| Borre_00170 borA3 | 2 |  | malonyl-CoA |
| 3 | | methylmalonyl-CoA | |
| Borre_00180 borA4 | 4 | | methylmalonyl-CoA |
| Borre_00190 borA5 | 5 |  | methylmalonyl-CoA |
| Borre_00200 borA6 | 6 |  | malonyl-CoA |
Reference
- Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
- Olano C, Wilkinson B, Moss SJ, Brana AF, Mendez C, Leadlay PF, Salas JA[PMID: 14651102]Chem Commun (Camb). (2003) 2780-2
- Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions.
- Olano C, Wilkinson B, Sanchez C, Moss SJ, Sheridan R, Math V, Weston AJ, Brana AF, Martin CJ, Oliynyk M, Mendez C, Leadlay PF, Salas JA[PMID: 15112998]Chem Biol. 11 (2004) 87-97
- Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: insights into nitrile formation.
- Olano C, Moss SJ, Brana AF, Sheridan RM, Math V, Weston AJ, Mendez C, Leadlay PF, Wilkinson B, Salas JA[PMID: 15186422]Mol Microbiol. 52 (2004) 1745-56
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Borrelidin |
|
|
|
|
|
History
- 2012-03-28[Release]
Advanced search
KS seq Analysis 
List
Other
Information
