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CDS information : A4092_00160


close this sectionLocation

Organism
StrainATCC 39727
Entry nameA40926
Contig
Start / Stop / Direction19,621 / 18,152 / - [in whole cluster]
19,621 / 18,152 / - [in contig]
Locationcomplement(18152..19621) [in whole cluster]
complement(18152..19621) [in contig]
TypeCDS
Length1,470 bp (489 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category3.4 other modification
Producthalogenase
Product (GenBank)halogenase
Gene
Gene (GenBank)dbv10
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[12837387] The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species. (Chem Biol. , 2003)
[17873036] Phosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926. (J Bacteriol. , 2007)
[25986904] Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727. (J Bacteriol. , 2015)
Related Reference
ACC
G4V4R7
NITE
Vanco_00150
PmId
[24756572] Bis-chlorination of a hexapeptide-PCP conjugate by the halogenase involved in vancomycin biosynthesis. (Org Biomol Chem. , 2014)
ACC
O87676
NITE
Balhi_00140
PmId
[11880037] Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase. (Chem Biol. , 2002)
[15342578] Biosynthesis of chloro-beta-hydroxytyrosine, a nonproteinogenic amino acid of the peptidic backbone of glycopeptide antibiotics. (J Bacteriol. , 2004)
ACC
R4T052
PmId
[24884615] Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis. (BMC Genomics. , 2014)

close this sectionSequence

selected fasta
>halogenase [halogenase]
MEEFDVVVAGGGPGGSTVATLVAMQGHRVLLVEKEVFPRYQIGESLLPSTVHGVCRMLGV
TDELAAAGFPVKRGGTFRWGARPEPWTFSFSVSPRITGPTTFAYQVERARFDEILLGNAR
RKGVVVREGCSVTEVIEDGDRVTGLRYVDPDGGEHAVSARFVIDASGNKSRLYSSVGGTR
NYSEFFRSLALFGYFEGGKRLAEPYSGNILSVAFDSGWFWYIPLSDTLTSVGAVVRREMA
EKIQGDREKALAALIAECPLISEYLAPARRVTTGKYGQLRVRKDYSYHQTKFWRPGMILV
GDAACFVDPVFSSGVHLATYSGLLAARSINSVLAGDVEEKIALHEFEARYRREYSVYYEF
LLAFYEMNVNEESYFWHAKKVTNNKEYTELESFVDLVGGLSSGETALATSGRIAERSAEF
AAAVDQMADGDDSSMVPLFKSQVVKQVMQEGGQEQMRAVLGADAEPEQPLFPGGLVTSPD
GMRWLTHHP
selected fasta
>halogenase [halogenase]
GTGGAAGAGTTCGATGTGGTGGTCGCCGGCGGCGGCCCTGGCGGTTCGACCGTGGCGACA
CTGGTGGCCATGCAGGGTCATCGGGTGCTGCTGGTGGAGAAGGAAGTCTTTCCGCGGTAT
CAGATCGGCGAGTCGTTGCTGCCCTCGACCGTGCACGGGGTGTGCCGGATGCTCGGGGTG
ACGGACGAGCTCGCGGCGGCGGGGTTTCCCGTGAAGCGCGGGGGCACCTTCCGGTGGGGG
GCGCGGCCGGAGCCGTGGACGTTCTCCTTCTCCGTCTCTCCGCGGATCACGGGTCCGACG
ACTTTCGCCTACCAGGTGGAGCGGGCACGCTTCGACGAGATCCTGCTCGGCAACGCCAGA
CGCAAGGGCGTGGTGGTGCGTGAGGGATGCTCGGTCACCGAGGTGATCGAGGACGGCGAT
CGGGTCACCGGCCTGCGTTACGTCGATCCTGACGGCGGCGAGCACGCGGTGTCCGCGCGT
TTCGTGATCGACGCGTCGGGCAACAAGAGCCGGTTGTATTCCAGCGTCGGTGGCACGCGG
AACTATTCGGAGTTCTTCCGCAGCCTGGCGCTGTTCGGTTACTTCGAGGGCGGCAAGCGG
CTGGCGGAGCCGTACTCGGGCAACATCCTGAGCGTGGCCTTCGACAGCGGCTGGTTCTGG
TACATCCCGCTGAGCGACACGCTGACCAGCGTGGGCGCGGTGGTGCGCCGGGAGATGGCG
GAGAAGATCCAGGGCGATCGGGAGAAGGCGCTGGCCGCGCTGATCGCCGAGTGCCCGCTG
ATCTCGGAGTACCTCGCGCCGGCGCGCCGGGTGACGACCGGCAAGTACGGGCAGCTGCGG
GTCCGCAAGGACTACTCCTACCACCAGACGAAGTTCTGGCGGCCCGGGATGATCCTGGTG
GGCGATGCCGCGTGCTTCGTGGACCCGGTGTTCTCCTCCGGGGTGCACCTGGCCACCTAC
AGCGGCCTCCTGGCGGCCCGGTCGATCAACAGCGTCCTGGCCGGTGACGTCGAGGAGAAG
ATCGCGCTGCATGAGTTCGAGGCGCGATATCGCCGCGAGTACAGCGTGTACTACGAGTTC
CTGCTGGCGTTCTACGAGATGAACGTGAACGAGGAGTCGTATTTCTGGCACGCCAAGAAG
GTCACCAACAACAAGGAGTACACCGAGCTGGAGTCGTTCGTGGACCTGGTGGGCGGTCTG
TCCTCCGGCGAGACGGCGCTGGCGACCTCAGGGCGGATCGCCGAGCGCAGCGCCGAGTTC
GCCGCGGCCGTCGATCAGATGGCCGACGGCGACGACTCCAGCATGGTGCCGCTGTTCAAG
TCACAGGTGGTCAAACAGGTGATGCAGGAGGGCGGGCAGGAGCAGATGAGGGCGGTGCTC
GGTGCGGACGCCGAGCCCGAGCAGCCACTGTTCCCCGGCGGGCTGGTGACCTCACCCGAC
GGGATGAGATGGCTGACACATCACCCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR003042 Aromatic-ring hydroxylase-like (Domain)
 [5-27]  1.10000029896148e-07 PR00420 [158-173]  1.10000029896148e-07 PR00420 [294-309]  1.10000029896148e-07 PR00420
PR00420   RNGMNOXGNASE
IPR006905 Tryptophan halogenase (Family)
 [5-92]  1.8e-24 PF04820 [97-425]  1.10000000000001e-73 PF04820
PF04820   Trp_halogenase
SignalP No significant hit
TMHMM No significant hit