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CDS information : A4092_00210


close this sectionLocation

Organism
StrainATCC 39727
Entry nameA40926
Contig
Start / Stop / Direction24,873 / 24,664 / - [in whole cluster]
24,873 / 24,664 / - [in contig]
Locationcomplement(24664..24873) [in whole cluster]
complement(24664..24873) [in contig]
TypeCDS
Length210 bp (69 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.4 Other
Productputative MbtH-like protein
Product (GenBank)Dbv15 protein
Gene
Gene (GenBank)dbv15
EC number
Keyword
Note
Note (GenBank)
Reference
ACC
PmId
[12837387] The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species. (Chem Biol. , 2003)
[17873036] Phosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926. (J Bacteriol. , 2007)
[25986904] Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727. (J Bacteriol. , 2015)
Related Reference
ACC
Q939Y8
NITE
Balhi_00100
PmId
[11932455] Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. (Microbiology. , 2002)
[16907743] The small MbtH-like protein encoded by an internal gene of the balhimycin biosynthetic gene cluster is not required for glycopeptide production. (FEMS Microbiol Lett. , 2006)
[21826462] Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery. (J Ind Microbiol Biotechnol. , 2011)
ACC
Q50EC7
PmId
[16879412] A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus. (Mol Microbiol. , 2006)
ACC
Q8GHC8
PmId
[17464055] Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor. (Microbiology. , 2007)
[21890635] Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis. (J Biol Chem. , 2011)
ACC
E2EKP2
PmId
[20964365] Activation of the pacidamycin PacL adenylation domain by MbtH-like proteins. (Biochemistry. , 2010)
ACC
Q8RN06
NITE
Vanco_00110
PmId
[21890635] Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis. (J Biol Chem. , 2011)
ACC
A0A0A0V1G6
PmId
[27432613] Increased vancomycin production by overexpression of MbtH-like protein in Amycolatopsis orientalis KFCC10990P. (Lett Appl Microbiol. , 2016)

close this sectionSequence

selected fasta
>putative MbtH-like protein [Dbv15 protein]
MTNPFENEDGSFLVLVNDEGQHSLWPSFAEVPPGWTRVHGVATRQECLAYVEENWTDIRP
KSLIAEAGA
selected fasta
>putative MbtH-like protein [Dbv15 protein]
ATGACCAACCCGTTCGAGAACGAAGACGGCTCCTTCCTCGTGCTCGTCAACGACGAAGGA
CAGCACTCGCTCTGGCCCTCGTTCGCGGAGGTGCCGCCTGGCTGGACCCGCGTCCACGGC
GTGGCCACCCGCCAGGAATGCCTCGCCTACGTCGAGGAGAACTGGACGGACATCCGGCCG
AAGAGTCTCATCGCGGAAGCCGGCGCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR005153 MbtH-like protein (Domain)
 [3-53]  2.50000909916183e-36 SM00923
SM00923   MbtH
 [1-53]  1e-28 PF03621
PF03621   MbtH
IPR015166 Protein of unknown function DUF1922 (Family)
 [11-66]  2.80000000000001e-29 G3DSA:3.90.820.10
G3DSA:3.90.820.10   DUF1922
SignalP No significant hit
TMHMM No significant hit