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CDS information : A4793_00040


close this sectionLocation

Organism
StrainNRRL 15009
Entry nameA47934
Contig
Start / Stop / Direction6,267 / 4,960 / - [in whole cluster]
6,267 / 4,960 / - [in contig]
Locationcomplement(4960..6267) [in whole cluster]
complement(4960..6267) [in contig]
TypeCDS
Length1,308 bp (435 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category3.4 other modification
Productputative halogenase
Product (GenBank)StaK
GenestaK
ORF31
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
  • Nonheme halogenase
Reference
ACC
PmId
[12060705] Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. (Proc Natl Acad Sci U S A. , 2002)
Related Reference
ACC
Q7WZ81
NITE
A4092_00160
PmId
[12837387] The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species. (Chem Biol. , 2003)
ACC
O87676
NITE
Balhi_00140
PmId
[11880037] Glycopeptide biosynthesis in Amycolatopsis mediterranei DSM5908: function of a halogenase and a haloperoxidase/perhydrolase. (Chem Biol. , 2002)
[15342578] Biosynthesis of chloro-beta-hydroxytyrosine, a nonproteinogenic amino acid of the peptidic backbone of glycopeptide antibiotics. (J Bacteriol. , 2004)
ACC
G4V4R7
NITE
Vanco_00150
PmId
[24756572] Bis-chlorination of a hexapeptide-PCP conjugate by the halogenase involved in vancomycin biosynthesis. (Org Biomol Chem. , 2014)
ACC
R4T052
PmId
[24884615] Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis. (BMC Genomics. , 2014)

close this sectionSequence

selected fasta
>putative halogenase [StaK]
MSAETFDVVVAGGGPAGSTAASLVAMQGHRVLLVEKEVLPRHRVGESLLPSTVHGVCRML
GVTDELAETDFPVKRGATFQWGGRAEPWAFSFGASSRLTDATSFAYQADRARFDEILLKN
AKRKGVVVREGCSVTAVVEEGDRVTGLRHTDPDGGEHEVGARFVIDASGHESPLSASVGG
TRDRAGSFRGLALSGYFGNGCKRLPEPRSGDGLSVTFDGGWFWYVPLFGGLTSVGAVVSE
ERAEKLQDDREEAFKALIAECPAISDLLSEGMRVTAGKYGKLRVREDYVYHRTTFWRPGM
LLVGDAACSVDPLFSSGVHLATYSALLAARSINSVLAGDVDEKTALTEFEARYRRELGAF
SELLTTFHTMTGEEHPEPESFVDVAAGVSSGEWALAAQGGGAAAPGEPMFRGGLAVSPDG
MKWLPAASKEREDAR
selected fasta
>putative halogenase [StaK]
ATGTCGGCAGAGACGTTCGACGTGGTCGTGGCGGGGGGTGGGCCGGCGGGTTCGACCGCC
GCCTCCTTGGTGGCCATGCAGGGCCACCGGGTGCTTCTGGTGGAGAAAGAGGTCCTTCCG
CGCCACCGGGTCGGTGAGTCGTTACTTCCGTCCACGGTGCACGGCGTGTGCCGGATGCTC
GGTGTCACGGACGAGCTGGCGGAGACGGACTTCCCGGTGAAGCGGGGCGCGACGTTCCAG
TGGGGCGGTCGTGCGGAGCCGTGGGCCTTCTCCTTCGGGGCGTCGTCGCGGCTGACCGAC
GCGACGTCATTCGCCTACCAGGCGGACCGTGCGCGGTTCGACGAGATCCTGCTGAAAAAC
GCCAAGCGCAAGGGTGTGGTGGTCCGCGAAGGGTGCTCGGTCACCGCGGTGGTCGAGGAG
GGCGACCGGGTCACCGGCCTGCGCCACACCGACCCCGACGGCGGTGAGCACGAGGTCGGC
GCACGTTTCGTGATCGACGCGTCAGGCCATGAGAGCCCGTTGTCCGCCAGTGTCGGCGGC
ACCCGCGACCGTGCGGGGTCCTTCCGCGGCCTGGCACTGTCCGGGTACTTCGGGAACGGC
TGCAAGCGGCTGCCGGAACCGCGTTCGGGTGACGGCCTGAGCGTGACCTTCGACGGTGGC
TGGTTCTGGTACGTCCCGCTGTTCGGTGGGCTGACCAGCGTGGGCGCGGTGGTGAGCGAG
GAGCGGGCCGAGAAGCTCCAGGACGACCGCGAGGAGGCGTTCAAGGCCCTGATCGCCGAA
TGCCCGGCCATCTCGGATCTCCTCTCGGAGGGGATGCGGGTGACGGCCGGCAAATACGGG
AAACTGCGAGTCCGCGAGGACTACGTCTACCACCGGACGACGTTCTGGCGTCCGGGGATG
CTCCTGGTCGGAGACGCCGCGTGTTCCGTCGATCCGCTGTTCTCCAGCGGGGTTCACCTC
GCGACCTACAGCGCCCTGCTGGCCGCCCGTTCGATCAACAGCGTTCTCGCGGGCGATGTG
GACGAGAAGACCGCCCTGACGGAGTTCGAGGCGCGGTACCGCCGCGAGCTCGGCGCGTTC
TCCGAGTTGCTCACGACGTTCCACACGATGACCGGCGAGGAGCACCCGGAACCGGAGTCG
TTCGTGGACGTGGCCGCCGGAGTGTCGTCCGGTGAGTGGGCGCTCGCGGCACAGGGCGGA
GGAGCGGCAGCACCCGGGGAACCGATGTTCCGGGGTGGGCTGGCGGTCTCGCCCGACGGA
ATGAAGTGGCTGCCCGCCGCGTCGAAGGAACGAGAGGACGCCCGATGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR003042 Aromatic-ring hydroxylase-like (Domain)
 [7-29]  3.69999844802221e-08 PR00420 [160-175]  3.69999844802221e-08 PR00420 [297-312]  3.69999844802221e-08 PR00420
PR00420   RNGMNOXGNASE
IPR006905 Tryptophan halogenase (Family)
 [7-95]  4.6e-28 PF04820 [99-372]  2.20000000000002e-66 PF04820
PF04820   Trp_halogenase
SignalP No significant hit
TMHMM No significant hit