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CDS information : A4793_00095


close this sectionLocation

Organism
StrainNRRL 15009
Entry nameA47934
Contig
Start / Stop / Direction12,935 / 12,726 / - [in whole cluster]
12,935 / 12,726 / - [in contig]
Locationcomplement(12726..12935) [in whole cluster]
complement(12726..12935) [in contig]
TypeCDS
Length210 bp (69 aa)
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close this sectionAnnotation

Category1.4 Other
Productputative MbtH-like protein
Product (GenBank)
GenestaE
ORF25
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
Reference
PmId
[12060705] Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. (Proc Natl Acad Sci U S A. , 2002)
Related Reference
ACC
Q939Y8
NITE
Balhi_00100
PmId
[11932455] Nonribosomal biosynthesis of vancomycin-type antibiotics: a heptapeptide backbone and eight peptide synthetase modules. (Microbiology. , 2002)
[16907743] The small MbtH-like protein encoded by an internal gene of the balhimycin biosynthetic gene cluster is not required for glycopeptide production. (FEMS Microbiol Lett. , 2006)
[21826462] Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery. (J Ind Microbiol Biotechnol. , 2011)
ACC
Q8RN06
NITE
Vanco_00110
PmId
[21890635] Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis. (J Biol Chem. , 2011)
ACC
Q50EC7
PmId
[16879412] A glutamic acid 3-methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus. (Mol Microbiol. , 2006)
ACC
Q8GHC8
PmId
[17464055] Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor. (Microbiology. , 2007)
[21890635] Role of MbtH-like proteins in the adenylation of tyrosine during aminocoumarin and vancomycin biosynthesis. (J Biol Chem. , 2011)
ACC
E2EKP2
PmId
[20964365] Activation of the pacidamycin PacL adenylation domain by MbtH-like proteins. (Biochemistry. , 2010)
ACC
A0A0A0V1G6
PmId
[27432613] Increased vancomycin production by overexpression of MbtH-like protein in Amycolatopsis orientalis KFCC10990P. (Lett Appl Microbiol. , 2016)

close this sectionSequence

selected fasta
>putative MbtH-like protein
MTNPFDNEDGSFFVLVNDEGQHSLWPAFAEVPDGWTSVHGEAGRQDCLAYIEENWTDLRP
KSLIAEIGG
selected fasta
>putative MbtH-like protein
ATGACCAACCCCTTCGACAACGAGGACGGCTCCTTCTTCGTGCTCGTCAACGACGAGGGC
CAGCACTCCCTCTGGCCCGCCTTCGCCGAGGTGCCGGACGGCTGGACCTCCGTGCACGGC
GAGGCCGGCCGCCAGGACTGCCTCGCCTACATCGAGGAGAACTGGACCGACCTCCGGCCG
AAGAGCCTGATCGCGGAGATCGGCGGCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR005153 MbtH-like protein (Domain)
 [3-53]  6e-34 SM00923
SM00923   MbtH-like protein
 [1-53]  5.2e-30 PF03621
PF03621   MbtH
IPR015166 Protein of unknown function DUF1922 (Family)
 [11-66]  7.1e-29 G3DSA:3.90.820.10
G3DSA:3.90.820.10   no description
SignalP No significant hit
TMHMM No significant hit