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CDS information : Acla_00170


close this sectionLocation

Organism
StrainATCC 31615
Entry nameAclacinomycin A
Contig
Start / Stop / Direction18,678 / 19,496 / + [in whole cluster]
2,523 / 3,341 / + [in contig]
Location18678..19496 [in whole cluster]
2523..3341 [in contig]
TypeCDS
Length819 bp (272 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative transcriptional regulator
Product (GenBank)putative activator
Gene
Gene (GenBank)aknO
EC number
Keyword
  • SARP family
Note
Note (GenBank)
  • AknO
Reference
ACC
PmId
[11016846] A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin. (Mol Gen Genet. , 2000)
Related Reference
ACC
P25047
NITE
Adria_00210
PmId
[1729206] Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. (J Bacteriol. , 1992)
[7868593] Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. (J Bacteriol. , 1995)
[8971703] Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. (Mol Microbiol. , 1996)
[16545946] Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius. (Res Microbiol. , 2006)
[20529134] Modulation of dnrN expression by intracellular levels of DnrO and daunorubicin in Streptomyces peucetius. (FEMS Microbiol Lett. , 2010)
[20158521] Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation. (FEMS Microbiol Lett. , 2010)

close this sectionSequence

selected fasta
>putative transcriptional regulator [putative activator]
MDIWLLGPLTAEVRGRSIVPTAAKPRQILALLAIHANRVLPVGTLMEEIWGTEPPQSALA
TLHTYILQLRRRLTAAYGDEGGVSAKDVLVTQYGGYCWQAPTDSVDVPRYERLVTAGRIA
TAEDRQEEASAHFREALALWRGSALVDVRIGPVLSIEVARLEESRLGVLERCLEADLRLG
RHAELLAELTELTGRHPLHEGLHAQCMTALYRAGRSWQALDVYQRLRRRLAEELGLSPSP
RLQRLQQAVLSAEPWLDAPRYGGDPVFDRMIS
selected fasta
>putative transcriptional regulator [putative activator]
GTGGACATATGGTTGCTGGGACCGCTGACGGCCGAGGTGCGGGGCAGGTCGATCGTGCCC
ACCGCGGCGAAACCCCGACAGATCCTCGCCCTGCTCGCCATCCACGCCAATCGCGTCCTG
CCCGTCGGGACCCTGATGGAGGAGATCTGGGGCACCGAGCCGCCCCAGAGCGCCCTCGCC
ACCCTGCACACGTACATCCTCCAGCTGCGCCGCCGGCTGACCGCTGCCTACGGTGACGAG
GGGGGCGTGTCCGCCAAGGACGTCCTCGTCACCCAGTACGGCGGCTACTGCTGGCAGGCG
CCCACGGACTCCGTGGACGTACCGCGCTACGAACGGCTCGTCACCGCCGGACGGATCGCC
ACCGCCGAGGACCGCCAGGAGGAGGCGTCGGCCCACTTCCGTGAGGCACTCGCGCTCTGG
CGGGGGTCCGCGCTGGTGGACGTGCGGATCGGACCGGTCCTGAGCATCGAGGTGGCGCGG
CTGGAGGAGAGCAGGCTCGGCGTGCTGGAGCGCTGCCTGGAGGCGGACCTGAGGCTGGGA
CGCCACGCGGAGCTGCTGGCCGAACTCACCGAACTCACCGGGCGCCATCCGCTGCACGAG
GGCCTGCACGCCCAGTGCATGACGGCGCTGTACCGGGCGGGCCGCTCCTGGCAGGCGCTG
GACGTCTACCAGAGGCTGCGCCGCCGGCTGGCGGAGGAACTCGGACTCTCCCCGTCGCCG
CGCCTGCAGCGTCTGCAGCAGGCGGTGCTCTCGGCGGAGCCCTGGCTGGACGCGCCCAGG
TACGGAGGGGACCCGGTGTTCGACCGGATGATCAGCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001867 Signal transduction response regulator, C-terminal (Domain)
 [15-98]  4.09999599045784e-12 SM00862
SM00862   Trans_reg_C
 [17-98]  6.40000000000001e-19 PF00486
PF00486   Trans_reg_C
IPR005158 Bacterial transcriptional activator domain (Domain)
 [105-250]  2.70000000000002e-53 PF03704
PF03704   BTAD
 [105-250]  2.90000354677981e-55 SM01043
SM01043   BTAD
IPR011990 Tetratricopeptide-like helical (Domain)
 [115-225]  0.00011 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [22-101]  7.90000000000001e-10 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [1-99]  6.29999562859499e-14 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP
 [1-15]  0.522 Signal
Eukaryota   
TMHMM No significant hit