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CDS information : Alip_00080

Location

Organism	Streptomyces aureofaciens
Strain	Tü117
Entry name	Alpha-lipomycin
Contig	DQ176871
Start / Stop / Direction	11,284 / 10,415 / - [in whole cluster] 11,284 / 10,415 / - [in contig]
Location	complement(10415..11284) [in whole cluster] complement(10415..11284) [in contig]
Type	CDS
Length	870 bp (289 aa)

Annotation

Category	2.3 modification addition of sugar moiety
Product	putative glucose-1-phosphate thymidylyltransferase putative dTDP-glucose synthase
Product (GenBank)	LipDig1
Gene
Gene (GenBank)	lipDig1
EC number	2.7.7.24
Keyword	D-digitoxose
Note
Note (GenBank)	putative dNDP-glucose synthase
Reference	ACC Q30CS7 PmId [16723573] Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin. (Antimicrob Agents Chemother. , 2006)
Related Reference	ACC Q9AGY4 PmId [12147463] Homologs of the Rml enzymes from Salmonella enterica are responsible for dTDP-beta-L-rhamnose biosynthesis in the gram-positive thermophile Aneurinibacillus thermoaerophilus DSM 10155. (Appl Environ Microbiol. , 2002)

Sequence

>putative glucose-1-phosphate thymidylyltransferase [LipDig1]
MRGIVLAGGSGTRLRPVTRVASKQLLPVYNKPMIYYPLSVLMHAGIREILIISSPGFLGS
YRDLLGDGRWLGLEISYAEQPSPDGLADALRIGRHFAGDDTIALILGDNIFYSHQLPAML
QGERQRLDGCTLFGYPVADPERYGIAVTDADGTLLSLEEKPEKPRSNLAVTGLYFYDNDA
VDLVRGLTPSARGELEITDLNALYLTAGRARLVNLGRGSAWFDTGTHDSLLDAATFVQLI
EKRQGIRIACIEEVAYRMGFIDADQLFEIGRRTGMSTEYGRYVIDLAGT

>putative glucose-1-phosphate thymidylyltransferase [LipDig1]
ATGCGTGGAATCGTCCTGGCAGGGGGATCCGGCACGCGGCTGAGGCCCGTCACCCGCGTC
GCCTCGAAGCAGCTCCTGCCGGTCTACAACAAGCCGATGATCTACTACCCCCTGTCCGTG
CTGATGCACGCGGGCATCCGGGAGATCCTGATCATCAGCTCGCCGGGGTTCCTCGGCTCC
TACCGCGATCTGCTCGGTGACGGCCGATGGCTGGGCCTGGAGATCTCCTACGCCGAGCAG
CCGAGCCCCGACGGCCTCGCCGACGCCCTGCGCATCGGCCGGCACTTCGCGGGGGACGAC
ACCATCGCCCTCATTCTCGGCGACAACATCTTCTACAGCCACCAGCTGCCCGCCATGCTC
CAGGGCGAGCGGCAACGGCTCGACGGCTGCACCCTGTTCGGCTACCCGGTGGCCGACCCC
GAGCGGTACGGCATCGCCGTCACGGACGCCGACGGAACGCTGCTCTCGCTGGAGGAGAAG
CCGGAGAAGCCCCGGTCGAACCTGGCGGTGACCGGCCTGTACTTCTACGACAACGACGCC
GTGGACCTGGTACGTGGACTGACCCCCTCGGCCCGCGGCGAGCTGGAGATCACCGATCTC
AACGCCCTGTATCTGACGGCCGGCCGGGCCCGCCTGGTCAATCTGGGCCGCGGCAGCGCC
TGGTTCGACACCGGCACGCACGACAGCCTGCTCGACGCGGCGACGTTCGTGCAGCTCATC
GAGAAGCGCCAGGGCATCCGCATCGCCTGCATCGAGGAGGTGGCGTACCGCATGGGCTTC
ATCGACGCCGACCAGCTGTTCGAGATCGGCCGGCGGACCGGCATGAGCACCGAGTACGGC
CGGTACGTGATCGATCTGGCCGGCACCTGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR005835 Nucleotidyl transferase (Domain) PF00483 NTP_transferase IPR005907 Glucose-1-phosphate thymidylyltransferase, long form (Family) TIGR01207 rmlA
SignalP	No significant hit
TMHMM	No significant hit

Alip_00070 Alip_00090

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