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CDS information : Alip_00100

Location

Organism	Streptomyces aureofaciens
Strain	Tü117
Entry name	Alpha-lipomycin
Contig	DQ176871
Start / Stop / Direction	12,641 / 13,666 / + [in whole cluster] 12,641 / 13,666 / + [in contig]
Location	12641..13666 [in whole cluster] 12641..13666 [in contig]
Type	CDS
Length	1,026 bp (341 aa)

Annotation

Category	2.1 modification addition of extender units
Product	putative methyltransferase
Product (GenBank)	LipMt
Gene
Gene (GenBank)	lipMt
EC number	2.1.1.-
Keyword	glutamic acid
Note
Note (GenBank)	putative N-methyltransferase
Reference	ACC Q30CS5 PmId [16723573] Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin. (Antimicrob Agents Chemother. , 2006)
Related Reference	ACC P16559 PmId [1548230] Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. (J Bacteriol. , 1992)
Related Reference	ACC Q7X2G8 NITE Gilvo_00100 PmId [22800463] Roles of the Synergistic Reductive O-Methyltransferase GilM and of O-Methyltransferase GilMT in the Gilvocarcin Biosynthetic Pathway. (J Am Chem Soc. , 2012)

Sequence

>putative methyltransferase [LipMt]
MEVSLMGLAGMGWIAKSLTAAAELGLADHLDGTPMTAEELAKQTGTHPETLEALLRILSA
LGVFRRDDAGVYRNSALSDQLRDDHPQSMRHYVMLSGGLYADTFTAVTHTLRTGESAFRH
LHGTRIYEYLEQRPAEADLYDKAMADLARPVAAALAGTYDFGAVRSVLDVGGNSGELLKG
LLTAHPHLTGTCLDRPDVCARATAELAASDREDLKDRLVYRPGDFLQEVPAGSDLYTVKN
VLHNWNHEHSVVILGRIREAMERTDADRSAGRRARLLVIEPLIETDLDWMRVLFQMVVCE
DGTRGRTDEVQRAQIAEAGLEVLDTLRLSTGHTAHICAAAH

>putative methyltransferase [LipMt]
GTGGAAGTCAGCCTCATGGGCCTGGCGGGAATGGGCTGGATCGCGAAGTCGCTGACCGCC
GCCGCGGAACTCGGCCTCGCCGACCACCTCGACGGCACGCCGATGACCGCGGAGGAACTC
GCCAAGCAGACCGGGACCCATCCCGAGACGCTCGAGGCGCTGCTGCGGATCCTGTCCGCG
CTCGGCGTCTTCCGCCGCGACGACGCCGGCGTGTACCGCAACTCCGCGCTGTCCGACCAG
CTCCGCGACGACCACCCGCAGTCGATGCGGCACTACGTGATGCTCTCCGGCGGCCTGTAC
GCCGACACCTTCACCGCCGTCACCCACACCCTGCGCACCGGCGAGTCCGCCTTCCGCCAC
CTGCACGGCACCCGCATCTACGAGTACCTCGAGCAGCGGCCCGCCGAGGCGGACCTGTAC
GACAAGGCCATGGCCGACCTGGCCCGGCCCGTCGCCGCGGCCCTCGCCGGGACCTACGAC
TTCGGCGCCGTCCGCAGTGTGCTCGACGTCGGCGGCAACAGCGGAGAGCTGCTCAAGGGG
CTGCTCACCGCCCACCCGCACCTGACCGGTACGTGCCTGGACCGGCCGGACGTCTGTGCC
CGCGCCACCGCTGAACTGGCCGCCTCCGACCGCGAGGACCTCAAGGACCGGCTCGTCTAC
CGGCCGGGTGACTTCCTTCAGGAGGTGCCCGCCGGCTCCGACCTGTACACCGTCAAGAAC
GTGCTGCACAACTGGAACCACGAGCACAGCGTCGTGATCCTCGGCCGCATCCGGGAGGCC
ATGGAGCGCACCGACGCCGACCGGTCCGCCGGCCGGCGGGCCCGGCTGCTGGTCATCGAG
CCACTGATCGAGACCGACCTCGACTGGATGCGCGTGCTGTTCCAGATGGTCGTCTGCGAG
GACGGCACCCGAGGCCGCACCGATGAGGTCCAGCGGGCCCAGATCGCCGAGGCCGGCCTC
GAGGTGCTCGACACGCTCCGCCTCTCCACAGGTCACACCGCCCACATCTGCGCCGCCGCT
CACTGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR001077 O-methyltransferase, family 2 (Domain) PF00891 Methyltransf_2 IPR012967 Plant methyltransferase dimerisation (Domain) PF08100 Dimerisation IPR016461 O-methyltransferase, COMT, eukaryota (Family) PIRSF005739 O-mtase
SignalP	Eukaryota Bacteria, Gram-negative
TMHMM	No significant hit

Alip_00090 Alip_00110

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