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CDS information : Ansam_00080


close this sectionLocation

Organism
StrainATCC 31565
Entry nameAnsamitocin
Contig
Start / Stop / Direction7,359 / 10,712 / + [in whole cluster]
75,388 / 72,035 / - [in contig]
Location7359..10712 [in whole cluster]
complement(72035..75388) [in contig]
TypeCDS
Length3,354 bp (1,117 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
ProductLuxR family transcriptional activator
Product (GenBank)transcriptional regulator
Gene
Gene (GenBank)asm8
EC number
Keyword
  • AHBA
Note
Note (GenBank)
Reference
ACC
PmId
[12060743] The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum. (Proc Natl Acad Sci U S A. , 2002)
[23832249] Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production. (Sci China Life Sci. , 2013)
Related Reference
ACC
Q06BL5
NITE
Gelda_00100
PmId
[18214443] The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. (Arch Microbiol. , 2008)

close this sectionSequence

selected fasta
>LuxR family transcriptional activator [transcriptional regulator]
MRLVDRDGQCEALAALLEGAAGGCGGAVLLRGAPGHGKTALLGRLVVMAEGAGFRCLVVE
ADALPEVAEVAAGGGALLVAVDDAGGADVGALFDLVAWARRTTAVLALTDLPRLPDDDPL
GAVARTPGALVLDLPPLRPETTAALLGGSPWPVTGGNPALVRGLAHDLVAGEAGPGAAYR
AALAGVLDRCGAEVAAVAHATAVLTGPAVGLLTAPAAALPAGLRAAPTAALLTAPAAVLP
GGVLPGAALPDGAHPAAGPGEACEGTAPAGEALSAAVRPGEACPGTALPDGVLPGVASPG
GAFPAADVLGGPFPAAVRSAAALPDWALPAAVRPGEACPGTALPTDAPPGAAPPGGALPD
GGARPLTSGEVGVRQGGVGPVAPGRAGASPGGAEPLVPGPVSGVRADPAGGDGASAFGRV
AADHVVPAGVRPRASSDPAAPVDLVADLLGRAPASVVDARARLAGAGLDRADPAAVLDVL
PAARRAELHLRAARTLHERGESPAVVADHLVTAGLPAPAWAVDVLVAAADHALAADDVPT
AVARLAAAHRRDDADQPRAVPPRAVPDPPVAAHRCGCADRTAAPAERRTSPEAAAVAGPA
LTARLARARWQLNPAAALCHLDPLADALAADPDALAPRDAAALVRQLVWHGRTTAAGRVL
AALRAREHAAELPDLETWLSLACPPLTASRRPTTLHASAPHTSAPRTSAHPTPLAPPPSR
VDPWLREAASLVGGFALGDQRRAAAEAAHYLRHAHLSHTSPWSEEPALLALLALVRADRA
ADADRACARLLDEARARRAPTWVASFAAAASVIALRLGDLAGAAGHARAALDAVPSHGWG
ASVGLPLGSLILADTLRGRRREAGRHVTAPVPDALFDGPAAPHYLHARGHHHLASGRDHA
ALADFLACGDLLRSWGLDLPGLAPWRTGAAEAWTRLGNHDRARRLVFDQLATTGADAGRP
RALALRALAPLSPPTRRPHLLAEAADALERCGDRYELAATLACLGAAHHALGDHRRARAV
LRRAWHLARACGARPLCARLEPDAADPVEHDTSGLTGSERKVAALAVTGLTNRQIAEKLF
VTPSTVEQHLTRVFRKLRVTHRADLPTTLHADLTTPA
selected fasta
>LuxR family transcriptional activator [transcriptional regulator]
ATGCGGCTGGTGGACCGCGACGGGCAGTGCGAGGCGCTGGCTGCCCTGCTGGAGGGCGCG
GCGGGCGGGTGCGGGGGCGCGGTGCTGCTCAGGGGCGCGCCGGGGCACGGGAAGACCGCG
CTGCTGGGGCGCCTGGTCGTGATGGCCGAGGGCGCGGGGTTCCGGTGCCTGGTGGTCGAG
GCGGACGCGCTGCCCGAGGTCGCGGAGGTCGCGGCGGGCGGCGGCGCGCTGCTGGTGGCC
GTGGACGACGCCGGGGGCGCCGACGTGGGCGCGCTGTTCGACCTGGTGGCGTGGGCGAGA
CGCACGACCGCCGTCCTCGCGCTCACCGACCTGCCCCGCCTGCCCGACGACGACCCGCTG
GGCGCCGTGGCGCGCACGCCGGGCGCCCTCGTGCTCGACCTCCCGCCACTGCGACCGGAG
ACCACCGCCGCGCTGCTCGGCGGGTCCCCGTGGCCGGTGACCGGGGGGAACCCCGCGCTG
GTGCGCGGGCTGGCCCACGACCTCGTGGCGGGGGAGGCGGGACCGGGGGCCGCCTACCGC
GCCGCCCTCGCCGGGGTGCTCGACCGCTGCGGCGCCGAGGTGGCCGCCGTCGCGCACGCC
ACCGCCGTGCTCACCGGGCCCGCCGTTGGGCTTCTCACCGCACCCGCCGCCGCGCTTCCC
GCCGGGCTTCGCGCCGCACCCACCGCCGCGCTTCTCACCGCACCCGCCGCCGTGCTTCCC
GGCGGGGTGCTTCCTGGTGCCGCGCTTCCTGACGGGGCGCACCCTGCTGCGGGCCCTGGT
GAGGCGTGCGAAGGCACCGCGCCTGCTGGCGAGGCTCTTTCCGCTGCTGTGCGCCCTGGC
GAGGCGTGCCCAGGCACCGCGCTTCCCGACGGGGTGCTTCCGGGGGTCGCGTCTCCCGGC
GGGGCGTTCCCCGCCGCCGACGTTCTCGGCGGGCCCTTCCCCGCCGCCGTGCGTTCCGCC
GCCGCGCTTCCAGACTGGGCCCTCCCCGCCGCCGTGCGTCCCGGCGAGGCGTGCCCTGGC
ACCGCGCTTCCCACCGACGCGCCCCCTGGGGCCGCGCCCCCTGGCGGGGCGCTTCCCGAC
GGCGGGGCGCGACCGCTCACGTCTGGCGAGGTGGGCGTCCGGCAGGGGGGAGTGGGGCCG
GTCGCGCCCGGTCGCGCCGGTGCCTCGCCGGGGGGCGCTGAGCCGCTCGTGCCCGGCCCG
GTGTCTGGGGTGAGGGCTGATCCCGCCGGGGGGGACGGGGCTTCCGCGTTCGGTCGGGTG
GCTGCGGATCACGTCGTTCCCGCTGGGGTCCGCCCCCGCGCGTCCTCGGACCCCGCCGCG
CCCGTCGACCTGGTCGCCGACCTGCTCGGTCGGGCCCCCGCCTCCGTCGTCGACGCCCGC
GCCCGCCTCGCGGGAGCCGGGCTCGACCGGGCCGATCCCGCCGCTGTGCTGGACGTGCTG
CCCGCCGCCCGGCGCGCCGAGCTGCACCTGCGCGCCGCGCGGACGTTGCACGAGCGCGGT
GAGTCGCCCGCCGTCGTCGCCGACCACCTCGTCACCGCCGGGCTGCCCGCGCCCGCCTGG
GCCGTCGACGTGCTCGTCGCCGCCGCCGACCACGCGCTCGCCGCCGACGACGTGCCCACC
GCCGTCGCACGGCTCGCCGCCGCCCACCGCCGGGACGACGCGGACCAACCGCGGGCCGTC
CCCCCGCGCGCAGTCCCGGACCCGCCCGTCGCCGCCCACCGGTGCGGGTGCGCGGACCGG
ACGGCCGCGCCCGCCGAGCGCCGCACGTCGCCCGAGGCCGCCGCCGTCGCCGGGCCCGCG
CTCACCGCCCGGCTCGCCCGCGCGCGCTGGCAGCTCAACCCGGCTGCCGCGCTGTGCCAC
CTCGACCCGCTCGCCGACGCGCTCGCCGCCGACCCCGACGCGCTCGCCCCGCGGGACGCC
GCCGCGCTGGTGCGCCAGCTGGTCTGGCACGGGCGCACCACCGCCGCCGGGCGCGTGCTC
GCCGCGCTGCGCGCCCGCGAGCACGCCGCCGAGCTGCCCGACCTGGAGACCTGGCTCTCC
CTCGCCTGCCCGCCGCTCACCGCCTCCCGCCGCCCCACAACCCTCCACGCCTCCGCCCCG
CACACCTCCGCCCCGCGCACCTCGGCCCACCCCACCCCCCTCGCCCCACCCCCGAGCCGC
GTCGACCCGTGGTTGCGCGAGGCCGCCAGCCTGGTCGGCGGGTTCGCGCTCGGGGACCAG
CGCCGGGCCGCCGCCGAGGCCGCGCACTACCTGCGCCACGCCCACCTCAGCCACACCTCC
CCGTGGTCCGAGGAACCCGCGCTGCTCGCCCTGCTAGCCCTGGTGCGCGCCGACCGCGCC
GCCGACGCCGACCGGGCCTGCGCCCGGCTGCTCGACGAGGCCCGCGCCCGGCGCGCGCCC
ACCTGGGTCGCCTCCTTCGCCGCCGCCGCCTCGGTGATCGCGCTGCGGCTCGGCGACCTC
GCGGGCGCCGCCGGGCACGCCCGCGCCGCGCTCGACGCCGTCCCCTCGCACGGCTGGGGC
GCGTCCGTGGGCCTGCCGCTGGGCTCGCTGATCCTCGCCGACACCCTGCGCGGGCGGCGC
CGGGAGGCCGGGCGGCACGTCACCGCGCCCGTGCCGGACGCCCTCTTCGACGGCCCCGCC
GCCCCGCACTACCTGCACGCGCGCGGCCACCACCACCTCGCGTCCGGGCGGGACCACGCG
GCGCTCGCGGACTTCCTGGCGTGCGGCGACCTCCTGCGCTCGTGGGGCCTCGACCTGCCC
GGCCTCGCGCCGTGGCGCACCGGGGCCGCCGAGGCGTGGACCCGCCTGGGCAACCACGAC
CGCGCCCGGCGGCTGGTGTTCGACCAGCTCGCCACGACCGGCGCCGACGCGGGCCGCCCC
AGGGCGCTGGCGCTGCGCGCGCTCGCCCCGCTCAGCCCGCCGACCCGCCGCCCGCACCTG
CTCGCCGAGGCCGCCGACGCCCTGGAGCGCTGCGGTGACCGCTACGAGCTGGCCGCCACC
CTCGCCTGCCTCGGCGCCGCGCACCACGCCCTCGGCGACCACCGCCGCGCCCGCGCCGTG
CTGCGCAGGGCCTGGCACCTGGCCAGGGCGTGTGGCGCGCGACCGCTGTGCGCGCGCCTG
GAACCGGACGCGGCCGACCCCGTCGAGCACGACACCAGCGGCCTCACCGGCTCCGAGCGC
AAGGTCGCCGCCCTGGCCGTCACCGGCCTCACCAACCGGCAGATCGCCGAGAAGCTGTTC
GTCACCCCGAGCACCGTCGAGCAGCACCTGACCAGGGTGTTCCGCAAGCTGCGCGTCACC
CACCGCGCCGACCTGCCCACCACCCTGCACGCCGACCTGACCACCCCCGCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [1055-1069]  7.99999145876753e-09 PR00038 [1069-1085]  7.99999145876753e-09 PR00038 [1085-1097]  7.99999145876753e-09 PR00038
PR00038   HTHLUXR
 [1069-1096]  PS00622
PS00622   HTH_LUXR_1
 [1054-1105]  2e-13 PF00196
PF00196   GerE
 [1052-1109]  3.49999466863949e-21 SM00421
SM00421   HTH_LUXR
 [1048-1113]  PS50043
PS50043   HTH_LUXR_2
IPR011990 Tetratricopeptide-like helical (Domain)
 [745-1062]  2e-11 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [1063-1105]  1.3e-17 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [1033-1111]  1.39999892049878e-14 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP No significant hit
TMHMM No significant hit