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CDS information : Aran_00130


close this sectionLocation

Organism
StrainTü303
Entry nameAranciamycin
Contig
Start / Stop / Direction18,199 / 18,807 / + [in whole cluster]
18,199 / 18,807 / + [in contig]
Location18199..18807 [in whole cluster]
18199..18807 [in contig]
TypeCDS
Length609 bp (202 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative two-component system response regulator
Product (GenBank)regulator
Gene
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
  • orf13
Reference
ACC
PmId
[17357167] Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. (Chembiochem. , 2007)
Related Reference
ACC
Q54821
NITE
Adria_00100
PmId
[7868594] Regulation of daunorubicin production in Streptomyces peucetius by the dnrR2 locus. (J Bacteriol. , 1995)
[8892835] The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis. (J Bacteriol. , 1996)
[10846224] The dnrO gene encodes a DNA-binding protein that regulates daunorubicin production in Streptomyces peucetius by controlling expression of the dnrN pseudo response regulator gene. (Microbiology. , 2000)
[20122958] The activator/repressor protein DnrO of Streptomyces peucetius binds to DNA without changing its topology. (Int J Biol Macromol. , 2010)
[20529134] Modulation of dnrN expression by intracellular levels of DnrO and daunorubicin in Streptomyces peucetius. (FEMS Microbiol Lett. , 2010)
[20158521] Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation. (FEMS Microbiol Lett. , 2010)
ACC
O34723
PmId
[15090506] The membrane fluidity sensor DesK of Bacillus subtilis controls the signal decay of its cognate response regulator. (J Bacteriol. , 2004)

close this sectionSequence

selected fasta
>putative two-component system response regulator [regulator]
MIRVLLAEDEHLIRGALTALLSEEVGIDVVADTGTGRSVLSLSLQHRPDVVVLDVMLPDM
TGLEVAEQLQEHLPSCRILLLTSLGIPGTVRQALEQQVDGYLLKDAPPAALADAIRKVAG
GQRVIAPGLMLAAWESRANPLTPRETEILRWASEGGSVRDVADAARLSPGTVRNHLSSIV
TKLGARSRLDAVRIAQDAGWLP
selected fasta
>putative two-component system response regulator [regulator]
GTGATACGAGTACTGCTCGCGGAGGACGAACACCTGATACGGGGCGCCCTCACTGCCCTG
CTGAGCGAGGAGGTCGGAATCGACGTCGTCGCGGACACCGGTACCGGCCGTTCGGTGCTG
TCCCTGTCACTTCAGCACCGGCCCGACGTCGTCGTCCTCGACGTGATGCTGCCGGACATG
ACCGGACTGGAGGTCGCGGAACAACTCCAGGAACACCTGCCGTCCTGCCGCATCCTGCTG
CTCACCAGTCTCGGGATCCCGGGCACCGTCCGCCAGGCGCTGGAACAGCAGGTCGACGGT
TACCTGCTGAAGGACGCCCCGCCCGCGGCGCTGGCCGACGCGATCCGCAAGGTCGCGGGC
GGCCAGCGGGTCATCGCCCCGGGGCTGATGCTGGCCGCGTGGGAGAGCCGCGCCAACCCG
CTCACGCCCCGGGAGACTGAGATCCTGCGCTGGGCCTCCGAAGGGGGCAGTGTGCGGGAC
GTCGCGGACGCCGCCCGGCTGTCGCCGGGGACCGTCCGCAACCATCTCAGCAGCATCGTC
ACGAAGCTCGGGGCGCGCAGTCGTCTCGACGCGGTCCGGATAGCCCAGGACGCGGGCTGG
CTGCCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000792 Transcription regulator LuxR, C-terminal (Domain)
 [141-155]  7.40000780398342e-10 PR00038 [155-171]  7.40000780398342e-10 PR00038 [171-183]  7.40000780398342e-10 PR00038
PR00038   HTHLUXR
 [139-195]  2e-16 PF00196
PF00196   GerE
 [138-195]  1.10000150671642e-24 SM00421
SM00421   HTH_LUXR
 [134-199]  PS50043
PS50043   HTH_LUXR_2
IPR001789 Signal transduction response regulator, receiver domain (Domain)
 [2-115]  1.39999892049878e-28 SM00448
SM00448   REC
 [4-115]  2.7e-21 PF00072
PF00072   Response_reg
 [3-119]  PS50110
PS50110   RESPONSE_REGULATORY
IPR011006 CheY-like superfamily (Domain)
 [1-127]  6.90001478563507e-29 SSF52172
SSF52172   CheY_like
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [144-201]  3.8e-20 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [119-201]  2.70000183580794e-19 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP No significant hit
TMHMM No significant hit