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CDS information : Aran_00150


close this sectionLocation

Organism
StrainTü303
Entry nameAranciamycin
Contig
Start / Stop / Direction20,708 / 21,517 / + [in whole cluster]
20,708 / 21,517 / + [in contig]
Location20708..21517 [in whole cluster]
20708..21517 [in contig]
TypeCDS
Length810 bp (269 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative transcriptional regulator
Product (GenBank)pathway specific transcription activator
Gene
Gene (GenBank)
EC number
Keyword
  • SARP family
Note
Note (GenBank)
  • orf15
Reference
ACC
PmId
[17357167] Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. (Chembiochem. , 2007)
Related Reference
ACC
P25047
NITE
Adria_00210
PmId
[1729206] Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. (J Bacteriol. , 1992)
[7868593] Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. (J Bacteriol. , 1995)
[8971703] Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. (Mol Microbiol. , 1996)
[16545946] Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius. (Res Microbiol. , 2006)
[20529134] Modulation of dnrN expression by intracellular levels of DnrO and daunorubicin in Streptomyces peucetius. (FEMS Microbiol Lett. , 2010)
[20158521] Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation. (FEMS Microbiol Lett. , 2010)
ACC
Q83X29
PmId
[12791134] The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism. (Mol Microbiol. , 2003)
[20378964] Regulation of lankamycin biosynthesis in Streptomyces rochei by two SARP genes, srrY and srrZ. (Biosci Biotechnol Biochem. , 2010)
ACC
Q9XCC4
PmId
[11985721] Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. (Mol Microbiol. , 2002)
[16942604] Regulation of tylosin biosynthesis involving 'SARP-helper' activity. (Mol Microbiol. , 2006)

close this sectionSequence

selected fasta
>putative transcriptional regulator [pathway specific transcription activator]
MQMKLGVLGPLHAQLGGGSIVPTAGKPRQVLALLALRAGRAVPVSTLMEELWGDAPPRSA
STTLQTYVLHLRRAIAAALPEGCALSPKDVIGMSFGGYRLAAVVEEHDLAGFEDLALRGA
TALEAGDARAADDLLGRALDLWRGLALEDVPQGTVLELEAIGMEESRMQVLEQRITAGLR
LGRHALLIPELRVLTARHPLNENLSAQLMTAFHRAGSTWRALEEFRRLHRSVGEELGIEP
GVRLQRLHQAILSGEPEADELGLSPLLAG
selected fasta
>putative transcriptional regulator [pathway specific transcription activator]
ATGCAGATGAAACTCGGTGTCCTCGGTCCGCTCCACGCCCAGCTGGGCGGCGGCTCGATC
GTCCCCACGGCGGGCAAGCCCCGGCAGGTCCTCGCGCTCCTGGCCCTTCGCGCGGGGCGC
GCCGTGCCCGTGTCCACGCTGATGGAGGAGTTGTGGGGGGACGCCCCGCCCCGCAGCGCC
TCGACCACCCTGCAGACCTACGTCCTCCACTTACGCCGGGCCATAGCCGCCGCACTGCCC
GAGGGGTGCGCCCTCTCCCCGAAGGACGTCATCGGCATGTCCTTCGGCGGCTACCGGCTC
GCCGCGGTCGTCGAGGAACACGACCTGGCCGGCTTCGAGGACCTCGCGCTGCGCGGCGCG
ACCGCGCTGGAGGCCGGTGACGCCCGGGCCGCCGACGACCTGCTGGGGCGCGCCCTTGAC
CTATGGCGGGGGCTCGCGCTGGAGGACGTGCCGCAGGGCACGGTCCTGGAGCTGGAGGCC
ATCGGGATGGAGGAGTCGCGGATGCAGGTGCTGGAGCAGCGCATCACAGCCGGACTGCGG
CTGGGCCGGCACGCGTTGCTCATCCCCGAGCTGCGGGTGCTCACCGCCCGTCATCCGCTC
AACGAGAACCTCAGCGCCCAGCTCATGACGGCGTTCCACCGGGCCGGCAGCACCTGGCGG
GCGCTGGAGGAGTTCCGCCGGCTGCACCGCAGCGTCGGCGAGGAACTCGGTATCGAGCCC
GGTGTCCGGCTCCAGCGGCTGCACCAGGCGATCCTGAGCGGCGAACCGGAGGCCGACGAG
CTCGGCCTCAGCCCCCTGCTGGCGGGCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001867 Signal transduction response regulator, C-terminal (Domain)
 [18-100]  1.59999889349252e-13 SM00862
SM00862   Trans_reg_C
 [21-100]  1.6e-18 PF00486
PF00486   Trans_reg_C
IPR005158 Bacterial transcriptional activator domain (Domain)
 [107-252]  1.60000240695997e-40 SM01043
SM01043   BTAD
 [108-252]  3.80000000000003e-41 PF03704
PF03704   BTAD
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [25-81]  7.4e-09 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [2-101]  1.09999909120787e-14 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP
 [1-41]  0.892 Signal
Eukaryota   
TMHMM No significant hit