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CDS information : Asco_00090

Location

Organism	Streptomyces hygroscopicus subsp. ascomyceticus
Strain	ATCC 14891 (=NBRC 13981)
Entry name	Ascomycin
Contig	AF235504
Start / Stop / Direction	10,995 / 9,895 / - [in whole cluster] 10,995 / 9,895 / - [in contig]
Location	complement(9895..10995) [in whole cluster] complement(9895..10995) [in contig]
Type	CDS
Length	1,101 bp (366 aa)

Annotation

Category	2.1 modification addition of extender units
Product	putative oxidoreductase
Product (GenBank)	FkbI
Gene
Gene (GenBank)	fkbI
EC number
Keyword	methoxymalonyl-ACP
Note
Note (GenBank)	acyl CoA dehydrogenase
Reference	ACC Q9KIE5 PmId [10863099] The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. (Gene. , 2000) [14623185] Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. (J Mol Biol. , 2003)
Related Reference	ACC Q8KUG3 PmId [11996558] Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. (J Am Chem Soc. , 2002)

Sequence

>putative oxidoreductase [FkbI]
MPERDALLTDLVGDRAAEWDTSGELPRDLLVRLGADGLLCAEVAAEHGGLGLGSRENGEF
TAHVGSLCSSLRSVMTSQGMAAWTVQRLGDAGQRATFLKELTSGKLAAVGFSERQAGSDL
SAMRTRVRLDGDTAVVDGHKVWTTAAAYADHLVVFGLQEDGSGAVVVVPADTPGVRVERV
PKPSGCRAAGHADLHLDQVRVPAGAVLAGSGASLPMLVAASLAYGRKSVAWGCVGILRAC
RTAAVAHARTREQFGRPLGDHQLVAGHIADLWTAEQIAARVCEYASDHWDEGSPEMVPAT
ILAKHVAAERAAAGAATAAQVLASAGAREGHVVERAYRDAKLMEIIEGSSEMCRVMLAQH
ALALPA

>putative oxidoreductase [FkbI]
ATGCCTGAGCGTGACGCGCTGCTGACCGACCTTGTCGGTGACCGGGCCGCCGAGTGGGAC
ACGTCCGGCGAACTGCCGCGCGACCTGCTCGTCCGGCTCGGCGCCGACGGCCTGCTCTGC
GCGGAAGTGGCGGCCGAGCACGGCGGTCTGGGACTCGGCAGCCGGGAGAACGGCGAGTTC
ACCGCACACGTCGGCAGCCTCTGCAGTTCGCTGCGCAGTGTCATGACGTCGCAGGGCATG
GCCGCGTGGACCGTGCAGCGGCTCGGCGACGCCGGTCAGCGGGCGACCTTCCTGAAGGAG
CTGACCAGCGGGAAACTCGCGGCCGTCGGCTTCAGTGAGCGGCAGGCGGGCAGCGATCTG
TCGGCGATGCGGACGCGGGTTCGGCTCGACGGGGACACCGCTGTCGTCGACGGCCACAAG
GTCTGGACGACTGCCGCCGCCTACGCGGACCACCTGGTCGTCTTCGGTCTCCAGGAGGAT
GGTTCCGGTGCGGTGGTGGTCGTGCCCGCCGACACCCCCGGCGTACGCGTCGAGCGCGTC
CCGAAGCCGTCCGGCTGCCGCGCCGCCGGCCACGCCGATCTGCACCTGGACCAGGTGCGT
GTGCCGGCCGGCGCGGTCCTGGCCGGCTCCGGCGCGTCACTGCCGATGCTGGTCGCGGCG
TCACTCGCCTACGGGCGCAAGTCGGTCGCCTGGGGCTGCGTCGGGATCCTGCGGGCCTGC
CGCACCGCCGCGGTGGCCCACGCCCGGACCCGGGAGCAGTTCGGCCGGCCGCTCGGCGAC
CACCAACTCGTCGCCGGGCACATCGCCGACCTGTGGACCGCGGAGCAGATCGCGGCCCGC
GTGTGCGAGTACGCCAGCGACCACTGGGACGAGGGCTCGCCCGAGATGGTGCCCGCGACG
ATCCTGGCCAAGCACGTCGCCGCCGAACGAGCCGCCGCCGGGGCCGCGACCGCCGCACAG
GTGCTCGCGTCGGCAGGCGCGAGAGAGGGACACGTCGTCGAACGGGCGTACCGCGACGCC
AAGCTCATGGAGATCATCGAGGGCAGCAGCGAGATGTGCCGGGTGATGCTGGCCCAGCAC
GCGCTGGCGCTCCCGGCTTGA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR006090 Acyl-CoA oxidase/dehydrogenase, type 1 (Domain) PF00441 Acyl-CoA_dh_1 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain (Domain) PF02770 Acyl-CoA_dh_M G3DSA:2.40.110.10 Acyl_CoA_DH/ox_M IPR006092 Acyl-CoA dehydrogenase, N-terminal (Domain) PF02771 Acyl-CoA_dh_N IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal (Domain) SSF47203 AcylCoADH_C_like IPR009100 Acyl-CoA dehydrogenase/oxidase (Domain) SSF56645 AcylCoA_dehyd_NM IPR013764 Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (Domain) G3DSA:1.20.140.10 AcylCoA_DH_1/2_C IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal (Domain) G3DSA:1.10.540.10 AcylCoA_DH/ox_N
SignalP	No significant hit
TMHMM	No significant hit

Asco_00080 Asco_00100

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