close all open/close all

CDS information : Balhi_00340


close this sectionLocation

Organism
StrainDSM 5908
Entry nameBalhimycin
Contig
Start / Stop / Direction61,944 / 63,248 / + [in whole cluster]
61,944 / 63,248 / + [in contig]
Location61944..63248 [in whole cluster]
61944..63248 [in contig]
TypeCDS
Length1,305 bp (434 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category2.1 modification addition of extender units
Productputative 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase
Product (GenBank)hydroxyacyl-dehydrogenase
Gene
Gene (GenBank)dpgC
EC number
Keyword
  • Dpg
Note
Note (GenBank)
Reference
ACC
PmId
[11495926] A polyketide synthase in glycopeptide biosynthesis: the biosynthesis of the non-proteinogenic amino acid (S)-3,5-dihydroxyphenylglycine. (J Biol Chem. , 2001)
Related Reference
ACC
O52812
NITE
Chlor_00300
PmId
[11752437] Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine. (Proc Natl Acad Sci U S A. , 2001)
[15380180] DpgC is a metal- and cofactor-free 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase in the vancomycin biosynthetic pathway. (Chem Biol. , 2004)

close this sectionSequence

selected fasta
>putative 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase [hydroxyacyl-dehydrogenase]
MTAAPPTSPPGPRLDRPALAEAAGRVDDLLAELPPPSARTPGQREAASSALDGIRAMRAD
YVGAHAEAIYDELTDGRSRSLRIDELVRAAARAFPGLVPTDEQMAAERARPQAEKDGREI
DQGIFLRGILRAERAGPHLLDAMLQPTPRALKLLPGFTESGVVQMEAVRLERRDGVAYLT
LCRDDCLNAEDAQQVDDMETAVDLALLDPAVRVGLLRGGEMSHPRYRGRRVFCAGINLKK
LSSGGIPLVDFLLRRELGYIHKIVRGVVTEGSWHSRLTDKPWIAAVDSFAIGGGAQLLLV
FDHVLAASDAYFSLPAAKEGIIPGASNFRLSRFAGPRVARQVILGGRRIRADEPDARLLV
DEVVPPAELDAAIDAALARLDGEAVLANRRMLNLAEEPPDEFRRYMAEFALQQALRIYGE
DVIGKVGRFAAGSS
selected fasta
>putative 3,5-dihydroxyphenylacetyl-CoA 1,2-dioxygenase [hydroxyacyl-dehydrogenase]
GTGACGGCCGCACCCCCGACGTCTCCGCCGGGGCCGCGGCTCGACCGCCCGGCCCTGGCG
GAGGCAGCCGGCCGCGTCGACGACCTGCTCGCCGAACTGCCGCCGCCGTCCGCCCGGACC
CCCGGGCAACGCGAGGCCGCGTCTTCGGCGCTGGACGGGATCCGGGCGATGCGCGCGGAC
TACGTCGGGGCGCACGCCGAAGCGATCTACGACGAACTCACCGACGGCCGGTCCCGGTCC
CTGCGCATCGACGAGCTCGTCCGGGCCGCCGCCCGGGCCTTTCCCGGCCTGGTGCCCACG
GACGAGCAGATGGCGGCCGAGCGCGCGCGGCCGCAGGCGGAGAAGGACGGGCGGGAGATC
GACCAGGGCATCTTCCTGCGCGGGATCCTGCGGGCGGAGCGGGCCGGCCCGCACCTGCTC
GACGCCATGCTCCAGCCCACCCCGAGGGCGCTGAAGCTGCTCCCGGGATTCACCGAGTCC
GGTGTCGTGCAGATGGAGGCGGTCCGGCTGGAACGCCGGGACGGCGTCGCGTACCTGACC
CTGTGCCGGGACGACTGCCTCAACGCCGAGGACGCCCAGCAGGTCGACGACATGGAGACC
GCGGTCGACCTGGCGCTGCTCGACCCGGCCGTCCGGGTGGGGCTGCTGCGCGGCGGGGAG
ATGAGCCATCCCCGCTACCGGGGGCGCCGCGTGTTCTGCGCCGGCATCAACCTCAAGAAG
CTGAGCTCGGGCGGCATCCCGCTGGTCGATTTCCTGCTGCGGCGGGAGCTGGGGTACATC
CACAAGATCGTGCGCGGCGTGGTCACCGAAGGTTCGTGGCATTCGCGGCTGACCGACAAG
CCGTGGATCGCGGCCGTCGACTCCTTCGCCATCGGCGGCGGGGCCCAGCTGCTCCTCGTC
TTCGACCACGTGCTGGCCGCGTCCGACGCCTACTTCAGCCTGCCCGCGGCGAAGGAGGGG
ATCATCCCCGGCGCGTCGAACTTCCGGCTCTCCCGGTTCGCCGGGCCCCGCGTGGCCCGG
CAGGTGATCCTCGGCGGCCGCCGGATCCGGGCGGACGAGCCGGATGCCCGACTGCTCGTC
GACGAGGTCGTCCCGCCGGCGGAGCTGGACGCGGCGATCGACGCCGCGCTGGCCCGCCTG
GACGGGGAGGCGGTGCTGGCCAACCGGCGCATGCTGAACCTGGCCGAGGAACCGCCGGAC
GAATTCCGCCGGTACATGGCCGAGTTCGCCCTGCAGCAGGCGCTGCGGATCTACGGCGAA
GACGTGATCGGCAAGGTCGGCCGGTTCGCGGCGGGCTCGTCGTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001753 Crotonase, core (Domain)
 [171-382]  1.2e-21 PF00378
PF00378   ECH
SignalP No significant hit
TMHMM No significant hit