open/close all

CDS information : Borre_00150

Location

Organism	Streptomyces parvulus
Strain	Tü4055
Entry name	Borrelidin
Contig	AJ580915
Start / Stop / Direction	16,184 / 18,814 / + [in whole cluster] 16,184 / 18,814 / + [in contig]
Location	16184..18814 [in whole cluster] 16184..18814 [in contig]
Type	CDS
Length	2,631 bp (876 aa)

Annotation

Category	1.1 PKS
Product	polyketide synthase
Product (GenBank)	borrelidin polyketide synthase, type I
Gene
Gene (GenBank)	borA1
EC number
Keyword
Note
Note (GenBank)	Loading module (acyltransferase, acylcarrier protein)
Reference	ACC Q70I02 PmId [15112998] Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions. (Chem Biol. , 2004) [14651102] Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. (Chem Commun (Camb). , 2003)

PKS/NRPS Module

AT	322..642

ACP	694..767

Sequence

>polyketide synthase [borrelidin polyketide synthase, type I]
MTGSAVSAPFLQPPEPVSGHSERKSDPVLLVGAGRRARMADAVRAAGAQAGIDPAVLRRT
RATLITAGSAGAAGRLAAALRLTGATISLDTRETPTLLALHLAAQALRAGDTSYAVVGAE
LPDGNCALILARQSAATAEGAVPQAIVRTTTADRTTTADHAPAPDDHGSPAREAPHATRT
LSPGITQAPAEGFPGLLATLHDDTPLRPTAVTEHGSDATTVLVLLDQPQDAAPAAPLPWV
VSAPHTRALRATAATLAVHLDTTPAAPADVAHTLLTARPDRHRAAVVGADRATLTDGLRA
LATGGDAPHLVHGTATGSPRPVFVFPGQGSQWPGMAAELLETSEPFHDSVHACADALAEF
VDWSVLDVLRQAPDAPPLRRVDVLQPTLWATMVSLAEVWRSYGVEPAAVVGHCCGEIAAA
QVAGALDMRDAARLLAHRSRAWLRLVGKGTVISVATSGQDITRRMAAWPDSVELAALNGP
RSVALAGPPDVLDGIVNDLTDQGIHAKRIPGVDTVGHCSQVEVLRDHLLDVLRPVSPRPA
AVPFYSTVDGTERDTTTLDTDYWYLNTRSQVRFHQAVRNLLAAGHRSFVEVSPHPLLGAS
IEDTAAEFGLDDVAAVGTLRRGQGGTRRVLTSVAEAYVHGIDIDFTPAFTGTTPNRIDLP
TVEDHGIEGHGDDGGETWTDRVRTLPDEQREEALLDLVCRTVAAVLEADPAGTADAVAPD
TAFKEMGLGSLSAVRLRNGLREATGAHLPATIAYDHPTPAALARHLAMTLFDATGAAPAV
PAPSRDDEPIDAETAVLTALERADEALERLRAPHARTPRQETGRRIDELLRSLTDKARRM
RQADAVDDVDDPATDRFAAATDDEMFELLEKRFGIS

>polyketide synthase [borrelidin polyketide synthase, type I]
ATGACAGGCAGTGCTGTTTCGGCCCCATTCCTGCAGCCTCCCGAACCCGTCTCAGGGCAC
TCCGAACGGAAAAGCGATCCCGTCCTTCTCGTCGGCGCCGGACGCCGTGCCCGCATGGCG
GATGCCGTACGTGCCGCCGGCGCTCAGGCGGGCATCGACCCGGCCGTCCTACGGCGCACC
CGGGCCACCTTGATCACCGCGGGGAGCGCGGGAGCCGCAGGCCGGCTCGCCGCCGCCCTG
CGCCTGACCGGCGCCACGATCTCTCTGGACACCCGCGAGACACCCACACTGCTCGCCCTG
CACCTCGCCGCCCAAGCGCTGCGGGCGGGCGACACCTCTTACGCCGTCGTCGGTGCCGAA
CTTCCCGACGGGAACTGCGCGTTGATCCTGGCCAGGCAGTCAGCGGCAACCGCCGAGGGG
GCTGTGCCCCAGGCGATCGTCCGCACCACCACGGCGGACCGCACCACCACGGCGGATCAC
GCCCCTGCGCCCGACGACCACGGCAGCCCGGCCCGTGAAGCCCCGCATGCCACCCGCACG
TTGTCCCCAGGCATCACCCAGGCCCCCGCCGAGGGCTTCCCGGGCCTGCTGGCGACCCTG
CACGACGACACACCCCTGCGCCCCACCGCGGTCACCGAGCACGGCAGCGACGCCACCACC
GTCCTCGTCCTCCTCGACCAGCCCCAGGACGCCGCACCCGCGGCACCGCTCCCCTGGGTG
GTCTCGGCCCCCCACACCCGCGCCCTCCGGGCCACGGCCGCGACCCTGGCCGTCCACCTC
GACACCACACCGGCCGCACCCGCCGACGTCGCGCACACCCTGCTCACCGCGCGCCCCGAC
CGCCACCGTGCCGCCGTCGTCGGCGCGGACCGGGCCACCCTCACCGACGGACTGCGCGCA
CTCGCCACCGGAGGCGACGCGCCCCACCTCGTCCACGGCACCGCCACCGGATCGCCGCGT
CCCGTCTTCGTCTTCCCCGGCCAGGGGTCGCAGTGGCCCGGTATGGCCGCCGAACTCCTC
GAAACCAGCGAGCCCTTTCACGACAGCGTGCACGCTTGCGCCGACGCGCTGGCCGAGTTC
GTCGACTGGTCGGTTCTCGACGTCCTGCGCCAGGCACCGGACGCGCCACCCCTGCGCCGG
GTGGACGTTCTCCAGCCCACCCTGTGGGCGACGATGGTCTCCCTGGCCGAGGTCTGGCGC
TCGTACGGCGTGGAACCGGCCGCCGTCGTCGGCCACTGCTGCGGCGAGATCGCCGCCGCG
CAGGTAGCCGGCGCCCTCGACATGCGTGACGCCGCCCGACTGCTCGCCCACCGCAGCCGG
GCCTGGCTGCGACTGGTGGGCAAGGGCACGGTCATCTCCGTCGCCACCTCGGGACAGGAC
ATCACCCGGCGCATGGCGGCCTGGCCCGACTCCGTCGAACTGGCCGCGCTCAACGGCCCG
CGCTCCGTGGCGCTCGCAGGCCCGCCCGACGTCCTGGACGGCATCGTCAACGACCTGACC
GACCAGGGCATCCACGCCAAACGCATCCCCGGCGTGGACACCGTCGGCCACTGCTCCCAG
GTCGAGGTCCTCCGCGACCACCTGCTGGACGTCCTGCGCCCGGTCTCGCCCCGGCCCGCC
GCCGTGCCGTTCTACTCCACCGTCGACGGAACCGAACGCGACACCACCACGCTGGACACC
GACTACTGGTACCTCAACACCCGCAGCCAGGTCCGCTTCCACCAGGCCGTGCGGAACCTG
CTCGCCGCCGGACACCGCTCGTTCGTCGAGGTGAGCCCGCACCCGCTGCTCGGAGCCTCC
ATCGAGGACACCGCGGCCGAGTTCGGCCTCGACGACGTGGCCGCCGTCGGCACCCTGCGT
CGAGGCCAGGGCGGCACCCGCCGGGTCCTGACCTCGGTGGCGGAGGCGTATGTCCACGGC
ATCGACATCGACTTCACGCCCGCCTTCACCGGCACGACCCCCAACCGCATCGACCTTCCG
ACCGTCGAGGACCACGGCATCGAGGGTCACGGCGACGACGGCGGCGAGACATGGACCGAC
CGCGTCAGAACCCTCCCGGACGAGCAGCGCGAAGAGGCTTTGCTGGACCTCGTGTGCCGC
ACCGTCGCCGCGGTGCTCGAAGCGGACCCGGCCGGCACGGCGGACGCCGTCGCCCCCGAC
ACGGCGTTCAAGGAGATGGGCCTCGGCTCACTGAGCGCGGTCCGGCTGCGCAACGGCCTC
CGCGAGGCCACCGGCGCCCACCTGCCGGCCACCATCGCCTACGACCACCCCACCCCGGCC
GCTCTGGCCCGCCACCTGGCGATGACCCTGTTCGACGCGACGGGCGCCGCCCCGGCGGTC
CCGGCACCGAGCCGCGACGACGAACCGATCGACGCCGAGACCGCTGTGCTGACCGCGCTG
GAACGGGCCGACGAGGCGCTGGAACGGTTGCGGGCCCCGCACGCCCGCACGCCCCGGCAG
GAGACCGGCCGGCGGATCGACGAGCTGCTGCGGTCCCTGACCGACAAGGCCAGGCGGATG
AGACAGGCCGACGCCGTCGATGATGTCGATGATCCGGCCACCGACCGGTTCGCCGCAGCC
ACCGACGACGAGATGTTCGAACTCCTCGAGAAACGTTTCGGCATCTCCTGA

[0] AT	322..642

[0] ACP	694..767

[0] AT	964..1926

[0] ACP	2080..2301

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR001227 Acyl transferase domain (Domain) G3DSA:3.40.366.10 Ac_transferase_reg IPR006163 Phosphopantetheine-binding (Domain) PF00550 PP-binding IPR009081 Acyl carrier protein-like (Domain) PS50075 ACP_DOMAIN SSF47336 ACP_like IPR014030 Beta-ketoacyl synthase, N-terminal (Domain) PF00109 ketoacyl-synt IPR014043 Acyl transferase (Domain) PF00698 Acyl_transf_1 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain) SSF52151 Acyl_Trfase/lysoPlipase IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain) SSF55048 Malonyl_transacylase_ACP-bd IPR016039 Thiolase-like (Domain) SSF53901 Thiolase-like IPR020801 Polyketide synthase, acyl transferase domain (Domain) SM00827 PKS_AT IPR020806 Polyketide synthase, phosphopantetheine-binding (Domain) SM00823 PKS_PP
SignalP	Eukaryota
TMHMM	No significant hit

Borre_00140 Borre_00160

Advanced search

KS seq Analysis

List

Other

Information