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Borre_00150 Borre_00150   Borre_00170 Borre_00170

CDS information : Borre_00160


close this sectionLocation

Organism
StrainTü4055
Entry nameBorrelidin
Contig
Start / Stop / Direction18,875 / 23,590 / + [in whole cluster]
18,875 / 23,590 / + [in contig]
Location18875..23590 [in whole cluster]
18875..23590 [in contig]
TypeCDS
Length4,716 bp (1,571 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category1.1 PKS
Productpolyketide synthase
Product (GenBank)borrelidin polyketide synthase, type I
Gene
Gene (GenBank)borA2
EC number
Keyword
Note
Note (GenBank)
  • Module 1 (b-ketoacyl-ACP-synthase, acyltransferase, ketoreductase, acylcarrier protein)
Reference
ACC
PmId
[15112998] Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions. (Chem Biol. , 2004)
[14651102] Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. (Chem Commun (Camb). , 2003)

close this sectionPKS/NRPS Module

1 malonyl-CoA
KS34..410
AT558..864
KR1138..1314
ACP1419..1489

close this sectionSequence

selected fasta
>polyketide synthase [borrelidin polyketide synthase, type I]
MAHEDKLRHLLKRVSAELDDTQRRVREMEESEREPIAIVGMSCRLPGGVNSPGEFWSLLE
AGTDAVSEFPRDRGWDVENLYDPDPDAPGRSYVREGGFLDGAGQFDAAFFGISPREALAM
DPQQRLLLECSWEAIERSRIDPKTLHGSRTGVFAGSNWQDYNTLLLNAEERSQSYLATGA
SGSVLSGRVSYTLGMEGPAITVNTACSSSLVAVHLAARSLRAGECDLALAGAVTVMSTPQ
LPVAFSRQRGLAPDGRSKAFAVSADGMGFGEGVGVLVLERLSVARRNGHRVLAVVRGSAV
NQDGASNGLTAPNGPSQQRVIRAALASAGLGPADVDVVEAHGTGTRLGDPIEAQALLATY
GRGRDAERPLWLGSVKSNIGHAQAAAGVAGVIKMVLAMEKGRLPRTLHVDEPSGEVDWDS
GAVRLLTEARDWPSEEGRLRRAGVSSFGISGTNAHVIIEEAPEEGEEPESDAGGVVPWVL
SARTEGALQAQAVQLSEFVGESSPVDVGWSLVSTRAAFEHRAVVVGRGRDELVRGLSEVA
QGRGVRGVASSASGGLAFVFAGQGSQRLGMGRGLYERFPVFAEAFDEVCGRVGPGVREVV
FGSDAGELDRTVWAQAGLFALEVALFRLLESWGVRPGCLIGHSVGELSAACVAGLWSLED
ACRVVAARARLMQALPAGGVMVAVRAEAGELAGFLGEDVVIASVNAPGQVVIAGPEGGVE
RVVAACGARSRRLAVSHAFHSPLVEPMLGEFRRVVESVAFGVPSLRVVSNVTGAWVDPEE
WGTPEYWVRQVREPVRFADGVATLLDAGVRTFVELGPAGALTSMVSHCADATATSVTAVP
TLRPDHDESRTVLSAAASLYVQGHPVDWAPLFPRARTVDLPTYPFQHQHYWLDVPPLFTA
SSAAQDGGWRYRIHWRRLGTRDSGDRLSGRWLLLVPESDGTEPWVEGAEKMLAERGCEVV
HVPIAATADRDAMVGAVRESVEDGRVDGVLSLLALDGRPHPDAAAVPTGLVATAQVVQVS
DELGIGPLWVATRQAVSVDGADEADGAGRTRKADDPADVAQAAVWGLGRVAALEKPRLWG
GLVDLPARADERMRDLVAQALTAPDAEDQLAVRADGIAVRRLVRSAASAPADDWQPSGTV
LVTGGTGGVGANVARWLVTQDIQHLLLVSRRGPDAPGAAELLAELSASGTSVTIEPCDVT
DADAVRRLIGAVPAERPLSTVVHAAGVLDDCLIDALTPQRLAAALEVKAKGALNLHEAAG
EAHLVLFSSLAGTTGTKGQGNYAAANAYLDALAERRRADGLPATSVAWGAWQGAGMVADA
AVAHRTRRYGLPLMSPDRAVATLRQVMAEPVATQVVADVDWQRFVADFTAVRPSRLLADL
PEVRSLGEQRKDGPGGQGEEDGLASKLAALPEADRRRAVLDLVEELVLGVLGHETRAAIG
PDSSFHAIGFDSLTAVELRNLLTVRLGMKLPATLVYDHPTLSSLADHLHEQLVIDGTPMT
DTAADLLAELDALAARLAAVGLEPEARARIGRRLKDMQTACEPRSESSRDLKSASRTEVL
DFLTNELGISR
selected fasta
>polyketide synthase [borrelidin polyketide synthase, type I]
ATGGCACATGAAGACAAACTGCGCCACCTCCTCAAGCGTGTCAGTGCTGAACTCGACGAC
ACCCAGCGCCGGGTGCGTGAGATGGAGGAGAGCGAGCGCGAGCCGATCGCGATCGTGGGG
ATGAGCTGCCGTCTGCCCGGCGGGGTGAACAGCCCGGGGGAGTTCTGGTCGCTGCTGGAG
GCCGGGACGGACGCCGTCTCGGAGTTCCCGCGGGACCGTGGCTGGGATGTGGAGAACCTC
TACGACCCGGACCCGGACGCCCCCGGGCGGTCGTACGTCCGCGAGGGCGGATTCCTGGAC
GGGGCCGGACAGTTCGACGCCGCCTTCTTCGGAATCTCGCCCCGTGAGGCGCTGGCGATG
GATCCGCAGCAGCGGCTGCTGCTGGAGTGCTCGTGGGAGGCGATCGAGCGGTCGCGGATC
GACCCGAAGACCCTGCACGGCAGCCGGACCGGCGTCTTCGCGGGCTCCAACTGGCAGGAC
TACAACACCCTGTTGCTGAACGCCGAGGAGCGCTCCCAGAGCTACCTGGCCACCGGCGCC
TCCGGAAGCGTGCTGTCCGGGCGCGTCTCGTACACGCTGGGCATGGAAGGGCCCGCGATC
ACCGTGAACACGGCGTGCTCGTCCTCTCTGGTCGCCGTCCACCTGGCGGCCCGTTCCCTG
CGGGCGGGGGAGTGCGACCTCGCCCTGGCCGGCGCCGTCACGGTCATGTCCACACCGCAG
CTTCCGGTCGCCTTCTCCCGGCAGCGCGGACTCGCCCCTGACGGTCGCTCGAAAGCCTTC
GCGGTTTCGGCCGACGGCATGGGCTTCGGCGAGGGGGTGGGCGTGCTTGTGCTGGAGCGG
TTGTCGGTGGCGCGGCGGAACGGTCATCGGGTGTTGGCGGTGGTGCGGGGTTCGGCGGTG
AACCAGGACGGTGCGTCGAACGGTCTGACGGCGCCGAACGGTCCGTCGCAGCAGCGGGTG
ATACGTGCGGCGTTGGCGAGTGCCGGGCTGGGTCCGGCCGATGTGGATGTGGTGGAGGCG
CACGGTACGGGGACGCGGTTGGGTGATCCGATCGAGGCGCAGGCGTTGCTGGCGACGTAC
GGGCGGGGCCGGGACGCGGAGCGTCCGTTGTGGCTGGGGTCGGTGAAGTCGAACATCGGT
CATGCGCAGGCTGCTGCCGGTGTCGCCGGTGTCATCAAGATGGTGCTGGCCATGGAGAAG
GGCCGTCTCCCTCGGACGCTGCATGTGGATGAGCCGTCGGGTGAGGTGGACTGGGACTCG
GGTGCGGTGCGGCTGCTGACCGAGGCGCGGGACTGGCCGTCGGAGGAAGGTCGTCTGCGG
CGGGCCGGTGTGTCGTCGTTCGGGATCTCAGGCACCAACGCGCACGTGATCATCGAGGAA
GCACCGGAAGAGGGGGAGGAACCGGAGTCCGACGCGGGTGGTGTGGTGCCGTGGGTGCTC
TCCGCGCGGACGGAAGGGGCACTGCAAGCACAGGCGGTGCAACTGAGCGAGTTCGTCGGC
GAGTCGAGTCCGGTGGATGTGGGTTGGTCGTTGGTTTCGACGCGTGCGGCGTTCGAGCAT
CGGGCCGTGGTGGTGGGGCGCGGGCGGGACGAGTTGGTGCGGGGCTTGTCCGAGGTCGCG
CAGGGTCGGGGCGTGAGGGGTGTCGCGTCTTCGGCGTCGGGTGGTCTCGCGTTTGTTTTT
GCTGGTCAGGGCAGTCAGCGGTTGGGGATGGGGCGGGGGTTGTATGAGCGGTTCCCGGTG
TTTGCCGAGGCGTTCGACGAGGTGTGTGGGCGGGTCGGTCCGGGGGTGCGGGAGGTTGTT
TTCGGTTCGGATGCGGGTGAGTTGGACCGGACGGTGTGGGCGCAGGCGGGGTTGTTCGCG
TTGGAGGTGGCGCTGTTTCGGTTGTTGGAGTCCTGGGGTGTGCGGCCGGGTTGTCTGATC
GGGCATTCGGTCGGTGAGTTGTCGGCGGCGTGTGTGGCGGGGTTGTGGTCGTTGGAGGAT
GCGTGTCGGGTCGTGGCTGCCCGGGCGCGGTTGATGCAGGCGTTGCCGGCGGGTGGGGTG
ATGGTCGCGGTTCGGGCCGAGGCGGGGGAGCTGGCCGGTTTCCTCGGTGAGGACGTGGTG
ATCGCGTCGGTGAACGCGCCGGGGCAGGTGGTGATCGCTGGTCCTGAGGGGGGTGTGGAG
CGTGTGGTGGCTGCTTGTGGGGCGCGGTCGCGTCGTCTGGCGGTCTCGCATGCTTTTCAT
TCGCCTTTGGTGGAGCCGATGCTTGGGGAGTTCCGTCGGGTTGTGGAGTCGGTGGCGTTC
GGTGTGCCGTCGTTGCGGGTGGTTTCCAATGTCACGGGTGCGTGGGTGGATCCGGAGGAG
TGGGGGACGCCGGAGTACTGGGTGCGTCAGGTCCGTGAGCCGGTGCGTTTCGCCGACGGG
GTCGCCACGTTGCTCGACGCGGGTGTGAGGACGTTCGTCGAGCTGGGTCCCGCCGGGGCG
CTCACTTCGATGGTCAGCCACTGCGCGGACGCCACCGCCACTTCGGTGACGGCTGTACCT
ACCTTGCGCCCCGATCACGATGAGTCGCGGACCGTGTTGAGTGCCGCAGCGTCCTTGTAC
GTCCAGGGTCACCCGGTCGACTGGGCCCCGCTGTTCCCGCGGGCCCGCACGGTGGACCTG
CCCACCTACCCCTTCCAGCACCAGCACTACTGGCTCGACGTACCTCCTCTGTTCACCGCC
TCCTCGGCGGCCCAGGACGGTGGCTGGCGATACCGCATCCACTGGCGGCGGCTCGGCACG
AGGGACTCCGGGGACCGGCTCTCCGGCCGCTGGTTGCTGCTGGTGCCCGAGTCGGACGGG
ACGGAGCCCTGGGTGGAGGGGGCCGAGAAGATGCTGGCCGAGCGCGGGTGCGAAGTCGTC
CACGTGCCGATCGCGGCGACGGCCGACCGGGACGCGATGGTCGGAGCCGTGCGTGAGAGC
GTCGAGGACGGTCGGGTCGACGGTGTGCTCAGCCTGCTGGCGCTCGACGGCCGCCCGCAC
CCCGATGCGGCTGCGGTGCCGACAGGGTTGGTCGCCACGGCGCAGGTTGTGCAGGTCAGT
GACGAGCTGGGCATCGGCCCGCTGTGGGTCGCCACCCGACAGGCGGTCTCCGTCGACGGG
GCCGATGAGGCTGACGGGGCCGGTAGGACCAGGAAGGCCGACGACCCCGCCGATGTCGCG
CAGGCCGCTGTGTGGGGGCTCGGCCGGGTCGCCGCGCTGGAGAAGCCTCGGTTGTGGGGC
GGCCTCGTCGACCTGCCCGCACGTGCCGACGAACGGATGCGGGACCTGGTGGCTCAGGCC
CTCACCGCTCCCGACGCCGAGGACCAACTTGCCGTGCGGGCCGACGGCATCGCCGTTCGC
CGACTGGTACGCTCCGCCGCGTCGGCCCCGGCCGACGACTGGCAGCCGAGCGGCACCGTG
CTGGTCACCGGCGGCACCGGAGGCGTCGGAGCCAACGTGGCGCGTTGGCTGGTCACCCAG
GACATCCAGCACCTGTTGCTGGTCAGCCGGCGCGGCCCGGACGCCCCCGGAGCCGCTGAG
CTGCTGGCCGAACTCAGCGCCTCAGGAACGTCCGTGACCATCGAGCCCTGCGACGTCACC
GACGCGGACGCGGTACGGCGCCTGATCGGCGCCGTACCGGCCGAACGGCCGCTGAGCACG
GTCGTCCACGCCGCGGGCGTACTGGACGACTGCTTGATCGACGCCCTGACCCCGCAGCGC
CTCGCCGCCGCACTGGAGGTCAAGGCCAAGGGCGCACTGAACCTCCACGAGGCGGCCGGG
GAAGCCCACTTGGTGCTCTTCTCCTCGCTGGCCGGAACAACCGGAACCAAGGGACAGGGC
AACTACGCCGCCGCAAACGCCTATCTCGACGCTCTGGCCGAACGGCGGCGTGCTGACGGC
CTGCCCGCCACTTCGGTCGCCTGGGGCGCCTGGCAGGGCGCGGGCATGGTGGCCGACGCC
GCCGTAGCCCACCGCACGCGCCGTTATGGCCTCCCGCTCATGAGCCCCGACCGCGCCGTC
GCCACCCTGCGGCAGGTCATGGCCGAGCCGGTGGCCACGCAGGTGGTGGCGGACGTCGAC
TGGCAGCGATTCGTCGCCGACTTCACCGCGGTGCGCCCCAGCCGCCTCCTCGCCGACCTG
CCGGAAGTGCGCTCCCTGGGCGAGCAGCGAAAGGACGGCCCGGGCGGTCAGGGCGAGGAG
GACGGCTTGGCCAGCAAGCTGGCAGCCCTGCCCGAAGCCGACCGCCGACGAGCCGTGCTG
GACCTCGTGGAGGAACTCGTCCTCGGGGTTCTGGGCCACGAGACGCGCGCGGCGATCGGC
CCGGACAGTTCCTTCCACGCCATCGGCTTCGACTCGCTCACCGCCGTCGAACTGCGCAAC
CTGCTGACCGTACGCCTCGGGATGAAGCTGCCCGCGACCCTCGTCTACGATCACCCGACC
CTGTCGTCGCTGGCCGACCACCTGCACGAGCAACTGGTTATCGACGGCACCCCCATGACG
GACACCGCGGCCGACCTGCTCGCCGAACTCGACGCACTCGCGGCGAGACTCGCCGCCGTC
GGGCTGGAACCGGAGGCGCGCGCCCGCATCGGACGCAGGCTCAAGGACATGCAGACCGCC
TGCGAACCCAGGTCGGAGTCCTCACGCGACCTGAAGTCCGCCTCACGCACCGAAGTGCTC
GACTTCCTCACCAACGAACTCGGCATCTCCCGCTGA
[1] KS34..410
[1] AT558..864
[1] malonyl-CoA737..741
[1] KR1138..1314
[1] ACP1419..1489
[1] KS100..1230
[1] AT1672..2592
[1] malonyl-CoA2209..2223
[1] KR3412..3942
[1] ACP4255..4467

close this sectionFeature

BLASTP
Database:UniProtKB:2010_04 		show BLAST table
InterPro
Database:interpro:26.0
IPR001227 Acyl transferase domain (Domain)
[554-831] 8.29994113369218e-75 G3DSA:3.40.366.10
G3DSA:3.40.366.10   Ac_transferase_reg
IPR006162 Phosphopantetheine attachment site (PTM)
[1447-1462] PS00012
PS00012   PHOSPHOPANTETHEINE
IPR006163 Phosphopantetheine-binding (Domain)
[1423-1488] 4.80000000000001e-09 PF00550
PF00550   PP-binding
IPR009081 Acyl carrier protein-like (Domain)
[1411-1506] 7e-21 SSF47336
SSF47336   ACP_like
[1419-1489] PS50075
PS50075   ACP_DOMAIN
IPR013968 Polyketide synthase, KR (Domain)
[1138-1313] 2.99999999999998e-55 PF08659
PF08659   KR
IPR014030 Beta-ketoacyl synthase, N-terminal (Domain)
[34-283] 2.39999999999997e-93 PF00109
PF00109   ketoacyl-synt
IPR014031 Beta-ketoacyl synthase, C-terminal (Domain)
[292-410] 9.40000000000003e-47 PF02801
PF02801   Ketoacyl-synt_C
IPR014043 Acyl transferase (Domain)
[558-864] 3.40000000000004e-59 PF00698
PF00698   Acyl_transf_1
IPR015083 Polyketide synthase, docking (Domain)
[1-27] 1.5e-05 PF08990
PF08990   Docking
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase (Domain)
[556-831] 1.1e-77 SSF52151
SSF52151   Acyl_Trfase/lysoPlipase
IPR016036 Malonyl-CoA ACP transacylase, ACP-binding (Domain)
[677-736] 1.9e-12 SSF55048
SSF55048   Malonyl_transacylase_ACP-bd
IPR016038 Thiolase-like, subgroup (Domain)
[36-297] 1e-79 G3DSA:3.40.47.10 [298-464] 8.10000734323342e-50 G3DSA:3.40.47.10
G3DSA:3.40.47.10   Thiolase-like_subgr
IPR016039 Thiolase-like (Domain)
[33-289] 3.9e-83 SSF53901 [251-467] 1.1e-78 SSF53901
SSF53901   Thiolase-like
IPR016040 NAD(P)-binding domain (Domain)
[1139-1303] 8.30001403791594e-28 G3DSA:3.40.50.720
G3DSA:3.40.50.720   NAD(P)-bd
[1131-1396] 1.8e-48 SSF51735
SSF51735   NAD(P)-bd
IPR018201 Beta-ketoacyl synthase, active site (Active_site)
[197-213] PS00606
PS00606   B_KETOACYL_SYNTHASE
IPR020801 Polyketide synthase, acyl transferase domain (Domain)
[559-846] 4.10001399699315e-110 SM00827
SM00827   PKS_AT
IPR020806 Polyketide synthase, phosphopantetheine-binding (Domain)
[1420-1492] 1.89999859865865e-22 SM00823
SM00823   PKS_PP
IPR020841 Polyketide synthase, beta-ketoacyl synthase region (Region)
[36-463] SM00825
SM00825   PKS_KS
IPR020842 Polyketide synthase/Fatty acid synthase, KR (Domain)
[1138-1314] 4.69998262513195e-41 SM00822
SM00822   PKS_KR
SignalP
[1-16] 0.079 Signal
Eukaryota   
TMHMM No significant hit
Borre_00150 Borre_00150   Borre_00170 Borre_00170
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