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CDS information : Borre_00210

Location

Organism	Streptomyces parvulus
Strain	Tü4055
Entry name	Borrelidin
Contig	AJ580915
Start / Stop / Direction	50,739 / 52,019 / + [in whole cluster] 50,739 / 52,019 / + [in contig]
Location	50739..52019 [in whole cluster] 50739..52019 [in contig]
Type	CDS
Length	1,281 bp (426 aa)

Annotation

Category	3.3 modification reduction
Product	putative cytochrome P450
Product (GenBank)	putative cytochrome P450
Gene
Gene (GenBank)	borI
EC number
Keyword	nitrile
Note
Note (GenBank)
Reference	ACC Q70HZ6 PmId [15112998] Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions. (Chem Biol. , 2004) [15186422] Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: insights into nitrile formation. (Mol Microbiol. , 2004)
Related Reference	ACC Q59831 PmId [7557483] Cloning, characterization and expression of the gene encoding cytochrome P-450sca-2 from Streptomyces carbophilus involved in production of pravastatin, a specific HMG-CoA reductase inhibitor. (Gene. , 1995)

Sequence

>putative cytochrome P450 [putative cytochrome P450]
MTTRRRQRHPALSPSCPSVPFPLLETEFVLMPSFPVRRSVPDTPPAEHLELLKESGGVCP
FTMEDGRPAWLAASHDAVRSLLADRRISNNPAKTPPFSQREALQKERGQFSRHLFNMDSP
EHDVARRMIAEDFTPRHAEAVRPYFEEVFGEIVDEVVHKGPPAEMIESFAFPVATRTICK
VLDIPEDDCEYFQKRTEQIIEMDRGEENLEAVVELRRYVDSVMQQRTRKPGDDLLSRMIV
KAKASKEIELSDADLVDNAMFLLVAGHEPSANMLGLGVLALAEFPDVAEELRAEPHLWPG
AIDEMLRYYTIARATKRVAAADIEYEGHTIKEGDAVIVLLDTSNRDPKVHAEPNRLDIHR
SAGNHLAFSHGPHQCLGKHLVRVQLEIALRAVAERLPGLRLDIAKEDIPFRGDALSYGPR
QLRVTW

>putative cytochrome P450 [putative cytochrome P450]
CTGACGACTCGCCGGCGACAGCGGCATCCCGCCCTGTCCCCTTCCTGTCCGTCCGTTCCC
TTTCCTCTCCTCGAAACGGAGTTCGTTCTCATGCCTTCCTTCCCCGTACGCCGGTCCGTG
CCCGACACTCCGCCCGCCGAGCACCTCGAACTGCTCAAGGAGAGCGGCGGCGTCTGCCCC
TTCACCATGGAGGACGGCCGTCCGGCCTGGCTCGCGGCCAGCCACGACGCCGTGCGCTCC
CTGCTCGCCGACCGCCGTATCAGCAACAACCCGGCGAAGACGCCGCCCTTCTCGCAGCGG
GAGGCCCTGCAGAAGGAGCGGGGCCAGTTCAGCCGTCACCTGTTCAACATGGACTCGCCG
GAGCACGACGTGGCCCGCCGCATGATCGCGGAGGACTTCACTCCCCGGCACGCCGAGGCG
GTCCGGCCGTACTTCGAGGAGGTGTTCGGCGAGATCGTCGACGAAGTGGTCCACAAGGGC
CCACCGGCCGAGATGATCGAGTCGTTCGCCTTCCCGGTCGCCACCCGCACCATCTGCAAG
GTGCTGGACATTCCGGAGGACGACTGCGAGTACTTCCAGAAGCGCACCGAGCAGATCATC
GAGATGGACCGCGGCGAGGAGAACCTCGAAGCCGTCGTCGAACTGCGCCGCTACGTCGAC
AGCGTCATGCAGCAGCGCACCCGCAAGCCCGGCGACGACCTGCTCAGCAGGATGATCGTC
AAGGCGAAGGCGTCCAAGGAGATCGAGCTCAGCGACGCCGACCTGGTCGACAACGCGATG
TTCCTGCTGGTGGCCGGGCACGAGCCGTCGGCCAACATGCTGGGCCTCGGCGTGCTCGCC
CTCGCCGAATTCCCGGACGTGGCCGAGGAACTGCGGGCCGAGCCGCACCTGTGGCCGGGC
GCGATCGACGAGATGCTCCGCTACTACACCATCGCCCGGGCCACCAAGCGGGTCGCGGCC
GCCGACATCGAGTACGAGGGGCACACGATCAAGGAGGGGGACGCCGTCATCGTGCTCCTC
GACACCAGCAACCGCGACCCGAAGGTGCACGCCGAACCGAACCGGCTCGACATCCACCGC
TCGGCGGGCAACCACCTGGCCTTCAGCCACGGACCGCACCAGTGCCTGGGCAAGCACCTC
GTCCGGGTCCAACTGGAGATCGCGCTGCGGGCTGTCGCCGAGCGGCTGCCCGGCCTGCGC
CTGGACATCGCCAAGGAGGACATCCCCTTCCGCGGTGACGCCCTGTCCTACGGGCCGCGC
CAGCTGCGCGTCACCTGGTAA

Feature

BLASTP Database:UniProtKB:2010_04	show BLAST table
InterPro Database:interpro:26.0	IPR001128 Cytochrome P450 (Family) G3DSA:1.10.630.10 Cyt_P450 PF00067 p450 SSF48264 Cytochrome_P450 IPR002397 Cytochrome P450, B-class (Family) PR00359 BP450 IPR017972 Cytochrome P450, conserved site (Conserved_site) PS00086 CYTOCHROME_P450 IPR017973 Cytochrome P450, C-terminal (Domain) PR00385 P450
SignalP	No significant hit
TMHMM	No significant hit

Borre_00200 Borre_00220

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