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CDS information : C1027_00570


close this sectionLocation

Organism
StrainC-1027
Entry nameC-1027
Contig
Start / Stop / Direction76,316 / 75,873 / - [in whole cluster]
76,316 / 75,873 / - [in contig]
Locationcomplement(75873..76316) [in whole cluster]
complement(75873..76316) [in contig]
TypeCDS
Length444 bp (147 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category5.1 general function
Productputative HxlR family transcriptional regulator
Product (GenBank)hypothetical protein
GenesgcE1
Gene (GenBank)
EC number
Keyword
Note
  • This ORF is not involved in C-1027 biosynthesis.
Note (GenBank)
  • ORF51
Reference
ACC
PmId
[12183628] Biosynthesis of the enediyne antitumor antibiotic C-1027. (Science. , 2002)
[21250756] Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. (J Nat Prod. , 2011)
Related Reference
ACC
P42406
PmId
[10572115] Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression. (J Bacteriol. , 1999)
[15978081] HxlR, a member of the DUF24 protein family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis. (Mol Microbiol. , 2005)
Family/Domain
FD
IPR002577

close this sectionSequence

selected fasta
>putative HxlR family transcriptional regulator [hypothetical protein]
MLPRTYEGQDCSLARSLEVIGERWNLLIVRSALLGACRYDEFLRQMPISRNVLADRLGRL
VDLGVMRRVVYQEKPVRHEYPLTPMGRELTVAVVALMQWGDRNLPAELGPSRQAQHTGCD
GGVRVRLGCASCGRDVHEDEVAVRRTR
selected fasta
>putative HxlR family transcriptional regulator [hypothetical protein]
ATGCTGCCACGGACGTACGAAGGACAGGACTGCTCGCTGGCCCGGTCCCTGGAAGTGATC
GGAGAGCGCTGGAACCTGCTGATCGTCCGCTCCGCCCTGCTGGGCGCCTGCCGGTACGAC
GAGTTCCTGCGCCAGATGCCGATCTCCCGGAACGTGCTGGCCGACCGTCTCGGCCGTCTC
GTCGACCTGGGTGTCATGCGGCGGGTCGTGTACCAGGAGAAGCCGGTACGCCACGAGTAC
CCGCTCACGCCCATGGGCCGTGAACTCACCGTCGCCGTGGTCGCCCTCATGCAGTGGGGC
GACCGGAACCTGCCCGCGGAGCTGGGACCGTCCCGGCAGGCGCAGCACACCGGATGCGAC
GGCGGTGTACGGGTGCGGCTGGGCTGCGCGTCCTGCGGGCGGGACGTCCACGAGGACGAG
GTGGCGGTACGCCGGACGCGCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR002577 Helix-turn-helix, HxlR type (Domain)
 [11-108]  PS51118
PS51118   HTH_HXLR
 [19-106]  6.3e-23 PF01638
PF01638   HxlR
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [10-99]  1e-08 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
SignalP No significant hit
TMHMM No significant hit