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CDS information : Dynm_00350


close this sectionLocation

Organism
StrainATCC 53710 (=NBRC 15963)
Entry nameDynemicin
Contig
Start / Stop / Direction49,086 / 49,514 / + [in whole cluster]
49,086 / 49,514 / + [in contig]
Location49086..49514 [in whole cluster]
49086..49514 [in contig]
TypeCDS
Length429 bp (142 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category3.1 modification hydroxylation
Productputative hydroxylase
Product (GenBank)putative hydroxylase
GenedynA1
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
  • ORF24
Reference
ACC
PmId
[18328078] The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710. (FEMS Microbiol Lett. , 2008)
Related Reference
ACC
Q9RN64
NITE
Nogl_00150
PmId
[16650858] Crystal structures of SnoaL2 and AclR: two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics. (J Mol Biol. , 2006)
[11683270] The entire nogalamycin biosynthetic gene cluster of Streptomyces nogalater: characterization of a 20-kb DNA region and generation of hybrid structures. (Mol Genet Genomics. , 2001)
[22633406] SnoaW/SnoaL2: a different two-component monooxygenase. (Chem Biol. , 2012)
[22633415] Discovery of a two-component monooxygenase SnoaW/SnoaL2 involved in nogalamycin biosynthesis. (Chem Biol. , 2012)

close this sectionSequence

selected fasta
>putative hydroxylase [putative hydroxylase]
MSAPDNKAVVRQLIDAWNNGDINALMTFWSPTMVHHGRAGTISAEDTAAEMRRFLDAFPD
LRMELHSIVSEGELVATRMTVHATHTGAYMGIPPTDRPVSCALMGQLRIVDGVVVDHWGV
ADALGILVQIGMLPSELSTAFS
selected fasta
>putative hydroxylase [putative hydroxylase]
GTGTCAGCACCTGACAACAAGGCGGTCGTGCGGCAGCTCATCGACGCCTGGAACAACGGC
GACATCAACGCCCTGATGACCTTCTGGTCACCGACGATGGTGCACCACGGCCGGGCCGGC
ACGATCAGCGCCGAGGACACCGCGGCCGAGATGCGGCGCTTCCTCGACGCCTTCCCCGAC
CTGCGCATGGAGCTGCACAGCATCGTCTCCGAGGGCGAACTCGTGGCCACCCGGATGACC
GTGCACGCCACGCACACCGGCGCGTACATGGGCATCCCGCCGACCGACCGCCCGGTGAGC
TGCGCCCTCATGGGGCAGTTGCGGATCGTCGACGGCGTCGTGGTCGACCACTGGGGGGTG
GCCGACGCGCTGGGCATCCTCGTGCAGATCGGAATGCTGCCGTCCGAACTGTCCACCGCC
TTTTCCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR009959 Polyketide cyclase SnoaL-like domain (Domain)
 [10-117]  2.2e-20 PF12680
PF12680   SnoaL_2
SignalP No significant hit
TMHMM No significant hit