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CDS information : Dynm_00450


close this sectionLocation

Organism
StrainATCC 53710 (=NBRC 15963)
Entry nameDynemicin
Contig
Start / Stop / Direction58,391 / 57,582 / - [in whole cluster]
58,391 / 57,582 / - [in contig]
Locationcomplement(57582..58391) [in whole cluster]
complement(57582..58391) [in contig]
TypeCDS
Length810 bp (269 aa)
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close this sectionAnnotation

Category4.3 transport
Productputative drug resistance ABC transporter permease protein
Product (GenBank)putative integral membrane transport protein
GenedynT8
Gene (GenBank)
EC number
Keyword
Note
Note (GenBank)
  • ORF34
Reference
ACC
PmId
[18328078] The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710. (FEMS Microbiol Lett. , 2008)
Related Reference
ACC
Q53717
PmId
[8326867] Streptomyces antibioticus contains at least three oleandomycin-resistance determinants, one of which shows similarity with proteins of the ABC-transporter superfamily. (Mol Microbiol. , 1993)
ACC
P32011
NITE
Adria_00140
PmId
[1924314] A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin. (Proc Natl Acad Sci U S A. , 1991)
[9006006] Expression and characterization of DrrA and DrrB proteins of Streptomyces peucetius in Escherichia coli: DrrA is an ATP binding protein. (J Bacteriol. , 1997)
[15709779] Biochemical characterization of domains in the membrane subunit DrrB that interact with the ABC subunit DrrA: identification of a conserved motif. (Biochemistry. , 2005)
[19063901] Translational coupling controls expression and function of the DrrAB drug efflux pump. (J Mol Biol. , 2009)
[20158521] Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation. (FEMS Microbiol Lett. , 2010)

close this sectionSequence

selected fasta
>putative drug resistance ABC transporter permease protein [putative integral membrane transport protein]
MTAVAAPHPANNARLLPSVGVLTGRALRIYRRTPQLLILRIVQSVAFLLIFRYVFGGAIG
TGTMRYVDFMAPGLLTVGIMFATIGTALGVAEDHVGGLFDRLRSLPMPRSAVLTGRVLAD
LAMTVAVLIPTIAIAFVVGMRVHTDWGSALGALGLLVLFGFAFVWIFVAVGLLAGSVQAA
QGISFIVMPISFASSAFVPTSSMPGWLQAFTEHQPVTVVVNAVRTLTQGAPAEALLGHST
GYYVTRALIWIIALTVVFAGLAIARYRSR
selected fasta
>putative drug resistance ABC transporter permease protein [putative integral membrane transport protein]
ATGACCGCCGTGGCCGCGCCGCACCCGGCCAACAACGCCCGCCTGCTGCCCAGCGTCGGC
GTGCTCACCGGTCGCGCCCTGCGCATCTACCGGCGCACGCCCCAACTGCTGATCCTGCGC
ATCGTGCAGTCGGTGGCGTTCCTGCTGATCTTCCGGTACGTGTTCGGTGGCGCGATCGGC
ACCGGCACGATGCGCTACGTCGACTTCATGGCGCCCGGCCTGCTCACGGTGGGGATCATG
TTCGCCACGATCGGCACCGCGCTCGGCGTGGCCGAGGACCACGTCGGCGGCCTCTTCGAC
CGGCTGCGGTCGCTGCCCATGCCGCGCAGCGCCGTGCTCACCGGCCGGGTCCTCGCCGAC
CTCGCCATGACCGTCGCGGTGCTCATCCCGACCATCGCCATCGCCTTCGTGGTGGGGATG
CGGGTGCACACCGACTGGGGCTCCGCGCTCGGCGCGCTGGGCCTCCTGGTGCTCTTCGGG
TTCGCCTTCGTCTGGATCTTCGTGGCGGTCGGGCTGCTGGCCGGCAGCGTCCAGGCGGCG
CAGGGCATCTCGTTCATCGTGATGCCGATCAGCTTCGCGTCCAGCGCCTTCGTGCCGACC
TCCAGCATGCCGGGCTGGCTCCAGGCGTTCACCGAGCACCAGCCCGTGACGGTGGTGGTC
AACGCGGTCCGCACCCTCACCCAGGGCGCCCCCGCCGAGGCGCTGCTCGGCCACAGCACC
GGCTACTACGTCACCCGGGCGCTGATCTGGATCATCGCACTGACCGTGGTCTTCGCGGGC
CTGGCCATCGCCCGCTACCGGAGCCGCTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR000412 ABC-2 (Family)
 [35-269]  PS51012
PS51012   ABC_TM2
IPR013525 ABC-2 type transporter (Domain)
 [19-225]  8.49999999999995e-27 PF01061
PF01061   ABC2_membrane
SignalP No significant hit
TMHMM
 [37-59]  Transmembrane (i-o) [69-91]  Transmembrane (o-i) [117-139]  Transmembrane (i-o) [154-176]  Transmembrane (o-i) [183-205]  Transmembrane (i-o) [242-264]  Transmembrane (o-i)
Transmembrane 6