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CDS information : Fred_00110


close this sectionLocation

Organism
StrainATCC 49344
Entry nameFredericamycin
Contig
Start / Stop / Direction11,020 / 11,487 / + [in whole cluster]
11,020 / 11,487 / + [in contig]
Location11020..11487 [in whole cluster]
11020..11487 [in contig]
TypeCDS
Length468 bp (155 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category3.4 other modification
Productputative cyclase/dehydratase
Product (GenBank)putative polyketide cyclase
GenefdmI
Gene (GenBank)
EC number
Keyword
  • 1st and 2nd ring
  • unreduced polyketide
Note
Note (GenBank)
  • FdmI
Reference
ACC
PmId
[16305230] Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. (J Am Chem Soc. , 2005)
Related Reference
ACC
P16559
PmId
[1548230] Nucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferase. (J Bacteriol. , 1992)
[8692863] Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase. (Proc Natl Acad Sci U S A. , 1996)
[9195917] Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits. (J Biol Chem. , 1997)
[18388203] Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. (Proc Natl Acad Sci U S A. , 2008)

close this sectionSequence

selected fasta
>putative cyclase/dehydratase [putative polyketide cyclase]
MAASTDNSVVVDAPMELLWDMTNDIESWPGLFSEYAKAEILGRDGATVTFRLTLHPDESG
AVWDWVSERTPDPATRTVRARRIETGPFVHMNILWTYASTDAGVEMRWRQEFEVKPGLPF
GDAEMTERLNTNTRREMARIKELVEKAAAERRAAR
selected fasta
>putative cyclase/dehydratase [putative polyketide cyclase]
ATGGCCGCCTCGACCGACAACTCCGTGGTCGTCGACGCCCCCATGGAGCTGCTCTGGGAC
ATGACCAACGACATCGAGTCCTGGCCCGGCCTGTTCTCCGAGTACGCCAAGGCGGAGATC
CTCGGCCGCGACGGCGCGACCGTCACCTTCCGTCTCACCCTCCACCCCGACGAGTCCGGC
GCCGTCTGGGACTGGGTTTCCGAGCGCACCCCCGACCCGGCCACCCGCACGGTCCGCGCC
CGGCGCATCGAGACGGGCCCGTTCGTCCACATGAACATCCTCTGGACCTACGCCAGCACC
GACGCGGGGGTGGAGATGCGCTGGCGCCAGGAGTTCGAGGTCAAGCCGGGTCTGCCGTTC
GGTGACGCCGAGATGACCGAGCGCCTCAACACCAACACACGGCGGGAGATGGCCCGCATC
AAGGAGCTGGTGGAGAAGGCGGCAGCCGAGCGGCGGGCGGCGCGGTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR019587 Polyketide cyclase/dehydrase (Family)
 [4-145]  9.60000000000001e-13 PF10604
PF10604   Polyketide_cyc2
IPR023393 START-like domain (Domain)
 [5-118]  6.80000000000001e-15 G3DSA:3.30.530.20
G3DSA:3.30.530.20   G3DSA:3.30.530.20
SignalP
 [1-38]  0.09 Signal
Bacteria, Gram-negative   
TMHMM No significant hit