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CDS information : Fren_00070


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Organism
StrainAK24158
Entry nameFrenolicin
Contig
Start / Stop / Direction10,091 / 10,939 / + [in whole cluster]
10,091 / 10,939 / + [in contig]
Location10091..10939 [in whole cluster]
10091..10939 [in contig]
TypeCDS
Length849 bp (282 aa)
Click on the icon to see Genetic map.

close this sectionAnnotation

Category4.1 transcriptional regulator
Productputative transcriptional regulator
Product (GenBank)pathway specific regulator
Gene
Gene (GenBank)frnG
EC number
Keyword
  • SARP family
Note
Note (GenBank)
  • FrnG; actII-ORF4 homolog
Reference
ACC
Related Reference
ACC
Q9XCC4
PmId
[11985721] Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. (Mol Microbiol. , 2002)
[16942604] Regulation of tylosin biosynthesis involving 'SARP-helper' activity. (Mol Microbiol. , 2006)
ACC
P25047
NITE
Adria_00210
PmId
[1729206] Regulation of secondary metabolism in Streptomyces spp. and overproduction of daunorubicin in Streptomyces peucetius. (J Bacteriol. , 1992)
[7868593] Functional characterization and transcriptional analysis of the dnrR1 locus, which controls daunorubicin biosynthesis in Streptomyces peucetius. (J Bacteriol. , 1995)
[8971703] Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. (Mol Microbiol. , 1996)
[16545946] Feedback regulation of doxorubicin biosynthesis in Streptomyces peucetius. (Res Microbiol. , 2006)
[20529134] Modulation of dnrN expression by intracellular levels of DnrO and daunorubicin in Streptomyces peucetius. (FEMS Microbiol Lett. , 2010)
[20158521] Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation. (FEMS Microbiol Lett. , 2010)

close this sectionSequence

selected fasta
>putative transcriptional regulator [pathway specific regulator]
MEIKYMGQLTMRWEGREKLPSARKPRTVLALLLLNDKTPVTTSALITELWGENPPRSALT
TLQTYILQLRKCLAAMSGRSLACISEKTLVTWPCGYLARLPADATSDVAEFRRFAREGRE
AERRGHLAEAVRSYRAALSLSQGPLLADIEHGPLLRAEAVRMEECRLSLVERSIEGDLLL
GRHREVVSELSALVAQYPYHEQLTGQLMVALVRCGRRQDALAVHQRLRARMVEDLGLEPS
SHLRALQSAVLSGEPLPGPPGTGGEIPTPYAGAFATAARSHD
selected fasta
>putative transcriptional regulator [pathway specific regulator]
GTGGAAATCAAGTACATGGGTCAGTTGACCATGCGGTGGGAGGGGCGGGAAAAGCTCCCC
TCGGCGCGCAAGCCGCGCACCGTGCTCGCCCTTCTGCTCCTCAACGACAAGACACCCGTC
ACGACCAGCGCACTCATCACGGAACTCTGGGGCGAGAACCCGCCGCGCAGCGCCCTGACC
ACCCTCCAGACCTATATTCTCCAGCTCCGGAAATGCCTCGCGGCGATGAGCGGGCGAAGC
CTCGCCTGCATATCCGAGAAAACCCTGGTGACGTGGCCCTGCGGTTATCTGGCGCGGCTT
CCGGCGGACGCCACTTCGGATGTGGCTGAATTCCGTCGGTTTGCCAGGGAGGGGCGGGAA
GCGGAACGCAGGGGTCATCTTGCCGAGGCCGTCCGCTCCTACCGCGCGGCGCTGTCACTG
AGCCAGGGACCACTCCTCGCCGATATCGAGCACGGGCCGCTGCTGCGCGCCGAGGCGGTA
CGCATGGAGGAGTGCCGGCTTTCGCTCGTCGAACGCTCCATCGAGGGCGACCTGCTCCTC
GGCCGGCACCGGGAGGTCGTCAGCGAACTGTCCGCCCTCGTCGCCCAGTACCCCTACCAC
GAACAGCTCACGGGGCAGCTCATGGTCGCGCTCGTGCGCTGTGGCCGCCGGCAGGACGCG
CTCGCCGTGCACCAACGGCTCCGGGCCCGCATGGTGGAGGACCTCGGCCTCGAACCGAGC
AGCCACCTGCGCGCCCTGCAGTCCGCCGTCCTCAGCGGCGAGCCGCTGCCGGGACCGCCC
GGAACCGGTGGCGAGATCCCCACCCCCTACGCGGGCGCTTTCGCCACCGCGGCGCGCTCG
CACGACTGA

close this sectionFeature

BLASTP
Database:UniProtKB:2011_09
show BLAST table
InterPro
Database:interpro:38.0
IPR001867 Signal transduction response regulator, C-terminal (Domain)
 [17-97]  1.1e-15 PF00486
PF00486   Trans_reg_C
IPR005158 Bacterial transcriptional activator domain (Domain)
 [106-251]  7.60000011115808e-43 SM01043
SM01043   BTAD
 [107-251]  5.40000000000002e-47 PF03704
PF03704   BTAD
IPR011990 Tetratricopeptide-like helical (Domain)
 [114-145]  0.00031 G3DSA:1.25.40.10 [190-227]  0.00031 G3DSA:1.25.40.10
G3DSA:1.25.40.10   TPR-like_helical
IPR011991 Winged helix-turn-helix transcription repressor DNA-binding (Domain)
 [23-75]  6.70000000000001e-07 G3DSA:1.10.10.10
G3DSA:1.10.10.10   Wing_hlx_DNA_bd
IPR016032 Signal transduction response regulator, C-terminal effector (Domain)
 [1-99]  2.59999946718995e-11 SSF46894
SSF46894   Bipartite_resp_reg_C-effector
SignalP No significant hit
TMHMM No significant hit